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@article{Jauhar:2017:10.1001/jamapsychiatry.2017.2943,
author = {Jauhar, S and Nour, MM and Veronese, M and Rogdaki, M and Bonoldi, I and Azis, M and Turkheimer, F and McGuire, P and Young, AH and Howes, OD},
doi = {10.1001/jamapsychiatry.2017.2943},
journal = {JAMA Psychiatry},
pages = {1206--1213},
title = {A Test of the Transdiagnostic Dopamine Hypothesis of Psychosis Using Positron Emission Tomographic Imaging in Bipolar Affective Disorder and Schizophrenia},
url = {http://dx.doi.org/10.1001/jamapsychiatry.2017.2943},
volume = {74},
year = {2017}
}

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TY  - JOUR
AB  - Importance  The dopamine hypothesis suggests that dopamine abnormalities underlie psychosis, irrespective of diagnosis, implicating dopamine dysregulation in bipolar affective disorder and schizophrenia, in line with the research domain criteria approach. However, this hypothesis has not been directly examined in individuals diagnosed with bipolar disorder with psychosis.Objectives  To test whether dopamine synthesis capacity is elevated in bipolar disorder with psychosis and how this compares with schizophrenia and matched controls and to examine whether dopamine synthesis capacity is associated with psychotic symptom severity, irrespective of diagnostic class.Design, Setting, and Participants  This cross-sectional case-control positron emission tomographic study was performed in the setting of first-episode psychosis services in an inner-city area (London, England). Sixty individuals participated in the study (22 with bipolar psychosis [18 antipsychotic naive or free], 16 with schizophrenia [14 antipsychotic naive or free], and 22 matched controls) and underwent fluorodihydroxyphenyl-l-alanine ([18F]-DOPA) positron emission tomography to examine dopamine synthesis capacity. Standardized clinical measures, including the Positive and Negative Syndrome Scale, Young Mania Rating Scale, and Global Assessment of Functioning, were administered. The study dates were March 2013 to November 2016.Main Outcomes and Measures  Dopamine synthesis capacity (Kicer) and clinical measures (Positive and Negative Syndrome Scale, Young Mania Rating Scale, and Global Assessment of Functioning).Results  The mean (SD) ages of participants were 23.6 (3.6) years in 22 individuals with bipolar psychosis (13 male), 26.3 (4.4) years in 16 individuals with schizophrenia (14 male), and 24.5 (4.5) years in controls (14 male). There was a significant group difference in striatal dopamine synthesis capacity (Kicer) (F2,57 = 6.80, P = .002). Kicer was significantly elevat
AU  - Jauhar,S
AU  - Nour,MM
AU  - Veronese,M
AU  - Rogdaki,M
AU  - Bonoldi,I
AU  - Azis,M
AU  - Turkheimer,F
AU  - McGuire,P
AU  - Young,AH
AU  - Howes,OD
DO  - 10.1001/jamapsychiatry.2017.2943
EP  - 1213
PY  - 2017///
SN  - 2168-622X
SP  - 1206
TI  - A Test of the Transdiagnostic Dopamine Hypothesis of Psychosis Using Positron Emission Tomographic Imaging in Bipolar Affective Disorder and Schizophrenia
T2  - JAMA Psychiatry
UR  - http://dx.doi.org/10.1001/jamapsychiatry.2017.2943
UR  - http://hdl.handle.net/10044/1/56382
VL  - 74
ER  -

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