Imperial College London
Alternate

DrOliverRatmann

Faculty of Natural Sciences, Department of Mathematics

Reader in Statistics and Machine Learning for Public Good
 
 
 
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Contact

 

oliver.ratmann05 Website

 
 
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Location

 

525Huxley BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Hoornenborg:2020:10.1016/j.jhep.2019.11.022,
author = {Hoornenborg, E and Coyer, L and Boyd, A and Achterbergh, RCA and van, der Loeff MFS and Bruisten, S and de, Vries HJC and Koopsen, J and van, de Laar TJW and Prins, M},
doi = {10.1016/j.jhep.2019.11.022},
journal = {Journal of Hepatology},
pages = {855--864},
title = {High incidence of HCV in HIV-negative men who have sex with men using pre-exposure prophylaxis},
url = {http://dx.doi.org/10.1016/j.jhep.2019.11.022},
volume = {72},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background & AimsHCV has emerged as a sexually transmitted infection (STI) among HIV-positive men who have sex with men (MSM). We evaluated HCV incidence and its risk factors among HIV-negative MSM using HIV pre-exposure prophylaxis (PrEP).MethodsParticipants of the Amsterdam PrEP project were tested for HCV antibodies or HCV-RNA every 6 months. Participants used daily or event-driven PrEP and could switch regimens during follow-up. We calculated incidence rates (IRs) for overall HCV infection and separately for primary and re-infection. A univariable Bayesian exponential survival model was used to identify risk factors associated with incident HCV infection. The HCV NS5B gene fragment (709 bp) was sequenced and compared to HCV isolates from HIV-positive MSM and other risk groups (n = 419) using phylogenetic analysis.ResultsAmong 350 participants contributing 653.6 person-years (PYs), we detected 15 HCV infections in 14 participants (IR = 2.30/100PY). There were 8 primary infections (IR = 1.27/100PY) and 7 re-infections (IR = 27.8/100PY). IR was 2.71/100PY in daily and 1.15/100PY in event-driven PrEP users. Factors associated with incident HCV infection were higher number of receptive condomless anal sex acts with casual partners (posterior hazard ratio [HR] 1.57 per ln increase; 95% credibility interval [CrI] 1.09–2.20), anal STI (posterior HR 2.93; 95% CrI 1.24–7.13), injecting drug use (posterior HR 4.69; 95% CrI 1.61–12.09) and sharing straws when snorting drugs (posterior HR 2.62; 95% CrI 1.09–6.02). We identified robust MSM-specific HCV clusters of subtypes 1a, 4d, 2b and 3a, which included MSM with and without HIV.ConclusionsHIV-negative MSM using PrEP are at risk of incident HCV infection, while identified risk factors are similar to those in HIV-positive MSM. Regular HCV testing is needed, especially for those with a previous HCV infection and those reporting risk factors.Lay summaryWe report that hepatitis C virus infections are
AU  - Hoornenborg,E
AU  - Coyer,L
AU  - Boyd,A
AU  - Achterbergh,RCA
AU  - van,der Loeff MFS
AU  - Bruisten,S
AU  - de,Vries HJC
AU  - Koopsen,J
AU  - van,de Laar TJW
AU  - Prins,M
DO  - 10.1016/j.jhep.2019.11.022
EP  - 864
PY  - 2020///
SN  - 0168-8278
SP  - 855
TI  - High incidence of HCV in HIV-negative men who have sex with men using pre-exposure prophylaxis
T2  - Journal of Hepatology
UR  - http://dx.doi.org/10.1016/j.jhep.2019.11.022
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000528847500016&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
UR  - https://www.sciencedirect.com/science/article/pii/S0168827819307196
VL  - 72
ER  -
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