Publications
380 results found
Singanayagam A, Manalan K, Sridhar S, et al., 2013, Evaluation of screening methods for identification of patients with chronic rheumatological disease requiring tuberculosis chemoprophylaxis prior to commencement of TNF-α antagonist therapy, THORAX, Vol: 68, Pages: 955-961, ISSN: 0040-6376
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- Citations: 24
Hewitt RJ, Wright C, Adeboyeku D, et al., 2013, Primary nodal anthracosis identified by EBUS-TBNA as a cause of FDG PET/CT positive mediastinal lymphadenopathy., Respiratory Medicine Case Reports, Vol: 10, Pages: 48-52, ISSN: 2213-0071
Isolated mediastinal lymphadenopathy can result from a number of potentially serious aetiologies. Traditionally those presenting with mediastinal lymphadenopathy would undergo mediastinoscopy to elucidate a final diagnosis or receive empirical treatment. There is now increased utilization of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA), in this setting. Five cases of mediastinal lymphadenopathy are presented here in which lymph node anthracosis was identified as the primary diagnosis using EBUS-TBNA. They were female, non-smokers presenting with non-specific symptoms, who retrospectively reported cooking over wood fires. Four were from South Asia. Three were investigated by F-18-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) scanning and increased signal was identified in the anthracotic nodes sampled. With expansion of PET/CT and EBUS-TBNA services it is likely that primary nodal anthracosis will be encountered more frequently and should be considered in the differential diagnosis of those with PET/CT positive lymphadenopathy. It may mimic pathologies including tuberculosis and malignancy, thus accurate sampling and follow-up are essential.
Pollock KM, Whitworth HS, Montamat-Sicotte DJ, et al., 2013, T-Cell immunophenotyping distinguishes active from latent tuberculosis, Journal of Infectious Diseases, Vol: 208, Pages: 952-968, ISSN: 0022-1899
Background. Changes in the phenotype and function of Mycobacterium tuberculosis (M. tuberculosis)-specific CD4+ and CD8+ T-cell subsets in response to stage of infection may allow discrimination between active tuberculosis and latent tuberculosis infection.Methods. A prospective comparison of M. tuberculosis-specific cellular immunity in subjects with active tuberculosis and latent tuberculosis infection, with and without human immunodeficiency virus (HIV) coinfection. Polychromatic flow cytometry was used to measure CD4+ and CD8+ T-cell subset phenotype and secretion of interferon γ (IFN-γ), interleukin 2 (IL-2), and tumor necrosis factor α (TNF-α).Results. Frequencies of CD4+ and CD8+ cells secreting IFN-γ-only, TNF-α-only and dual IFN-γ/TNF-α were greater in active tuberculosis vs latent tuberculosis infection. All M. tuberculosis-specific CD4+ subsets, with the exception of IL-2-only cells, switched from central to effector memory phenotype in active tuberculosis vs latent tuberculosis infection, accompanied by a reduction in IL-7 receptor α (CD127) expression. The frequency of PPD-specific CD4+ TNF-α-only-secreting T cells with an effector phenotype accurately distinguished active tuberculosis from latent tuberculosis infection with an area under the curve of 0.99, substantially more discriminatory than measurement of function alone.Conclusions. Combined measurement of T-cell phenotype and function defines a highly discriminatory biomarker of tuberculosis disease activity. Unlocking the diagnostic and monitoring potential of this combined approach now requires validation in large-scale prospective studies.
Finney L, Connell D, O'Donoghue M, et al., 2013, How long do patients with pulmonary tuberculosis remain smear and culture positive?, EUROPEAN RESPIRATORY JOURNAL, Vol: 42, ISSN: 0903-1936
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- Citations: 1
Footitt J, Mallia P, Ho WE, et al., 2013, Nitrosative and oxidative stress in virus-induced COPD exacerbations, EUROPEAN RESPIRATORY JOURNAL, Vol: 42, ISSN: 0903-1936
Anwar MS, Ross C, Wickremasinghe M, et al., 2013, A retrospective review of the Xpert® MTB/RIF assay performance in bronchoalveolar lavage samples in a London hospital, EUROPEAN RESPIRATORY JOURNAL, Vol: 42, ISSN: 0903-1936
Mallia P, Footitt J, Trujillo-Torralbo M-B, et al., 2013, Sputum neutrophil mediators in experimental rhinovirus infection in COPD, EUROPEAN RESPIRATORY JOURNAL, Vol: 42, ISSN: 0903-1936
Porter JD, Macintyre J, Sykes A, et al., 2013, Azithromycin is able to augment interferon and interferon stimulated gene responses to rhinovirus <i>in vitro</i>, World Allergy and Asthma Congress of the European-Academy-of-Allergy-and-Clinical-Immunology and World-Allergy-Organization, Publisher: WILEY-BLACKWELL, Pages: 300-300, ISSN: 0105-4538
Leahy AU, Lipman M, Hetzel M, et al., 2013, Do we need bacteriological confirmation of cure in uncomplicated tuberculosis?, EUROPEAN RESPIRATORY JOURNAL, Vol: 42, Pages: 860-863, ISSN: 0903-1936
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- Citations: 2
Mallia P, Message SD, Contoli M, et al., 2013, Neutrophil adhesion molecules in experimental rhinovirus infection in COPD, Respiratory Research, Vol: 14, ISSN: 1465-993X
BackgroundCOPD exacerbations are associated with neutrophilic airway inflammation. Adhesion molecules on the surface of neutrophils may play a key role in their movement from blood to the airways. We analysed adhesion molecule expression on blood and sputum neutrophils from COPD subjects and non-obstructed smokers during experimental rhinovirus infections.MethodsBlood and sputum were collected from 9 COPD subjects and 10 smoking and age-matched control subjects at baseline, and neutrophil expression of the adhesion molecules and activation markers measured using flow cytometry. The markers examined were CD62L and CD162 (mediating initial steps of neutrophil rolling and capture), CD11a and CD11b (required for firm neutrophil adhesion), CD31 and CD54 (involved in neutrophil transmigration through the endothelial monolayer) and CD63 and CD66b (neutrophil activation markers). Subjects were then experimentally infected with rhinovirus-16 and repeat samples collected for neutrophil analysis at post-infection time points.ResultsAt baseline there were no differences in adhesion molecule expression between the COPD and non-COPD subjects. Expression of CD11a, CD31, CD62L and CD162 was reduced on sputum neutrophils compared to blood neutrophils. Following rhinovirus infection expression of CD11a expression on blood neutrophils was significantly reduced in both subject groups. CD11b, CD62L and CD162 expression was significantly reduced only in the COPD subjects. Blood neutrophil CD11b expression correlated inversely with inflammatory markers and symptom scores in COPD subjects.ConclusionFollowing rhinovirus infection neutrophils with higher surface expression of adhesion molecules are likely preferentially recruited to the lungs. CD11b may be a key molecule involved in neutrophil trafficking in COPD exacerbations.
Hingley-Wilson SM, Casey R, Connell D, et al., 2013, Undetected Multidrug-Resistant Tuberculosis Amplified by First-line Therapy in Mixed Infection., Emerging Infectious Diseases, Vol: 19, Pages: 1138-1141
Sykes A, Edwards MR, Macintyre J, et al., 2013, TLR3, TLR4 and TLRs7-9 Induced Interferons Are Not Impaired in Airway and Blood Cells in Well Controlled Asthma, PLOS One, Vol: 8, ISSN: 1932-6203
Defective Rhinovirus induced interferon-β and interferon-λ production has been reported in bronchial epithelial cells from asthmatics but the mechanisms of defective interferon induction in asthma are unknown. Virus infection can induce interferon through Toll like Receptors (TLR)3, TLR7 and TLR8. The role of these TLRs in interferon induction in asthma is unclear. This objective of this study was to measure the type I and III interferon response to TLR in bronchial epithelial cells and peripheral blood cells from atopic asthmatics and non-atopic non-asthmatics. Bronchial epithelial cells and peripheral blood mononuclear cells from atopic asthmatic and non-atopic non-asthmatic subjects were stimulated with agonists to TLR3, TLR4 & TLRs7–9 and type I and III interferon and pro-inflammatory cytokine, interleukin(IL)-6 and IL-8, responses assessed. mRNA expression was analysed by qPCR. Interferon proteins were analysed by ELISA. Pro-inflammatory cytokines were induced by each TLR ligand in both cell types. Ligands to TLR3 and TLR7/8, but not other TLRs, induced interferon-β and interferon-λ in bronchial epithelial cells. The ligand to TLR7/8, but not those to other TLRs, induced only type I interferons in peripheral blood mononuclear cells. No difference was observed in TLR induced interferon or pro-inflammatory cytokine production between asthmatic and non-asthmatic subjects from either cell type. TLR3 and TLR7/8,, stimulation induced interferon in bronchial epithelial cells and peripheral blood mononuclear cells. Interferon induction to TLR agonists was not observed to be different in asthmatics and non-asthmatics.
Boshier PR, Mistry V, Cushnir JR, et al., 2013, Towards molecular assessment of surgical metabolic response: Exhaled breath signatures of major upper gastrointestinal surgery, Joint Meeting of the Section-of-Surgery of the Royal-Society-of-Medicine / Annual Meeting of the Society-of-Academic-and-Research-Surgery, Publisher: WILEY-BLACKWELL, Pages: 47-47, ISSN: 0007-1323
Pareek M, Bond M, Shorey J, et al., 2013, Community-based evaluation of immigrant tuberculosis screening using interferon γ release assays and tuberculin skin testing: observational study and economic analysis, THORAX, Vol: 68, Pages: 230-239, ISSN: 0040-6376
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- Citations: 58
Huang J, Kumar S, Singanayagam A, et al., 2013, Exhaled breath acetone for therapeutic monitoring in pneumonia using selected ion flow tube mass spectrometry (SIFT-MS), ANALYTICAL METHODS, Vol: 5, Pages: 3807-3810, ISSN: 1759-9660
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- Citations: 11
Christopherson TA, Kon OM, Elkin S, 2013, Educational Interventions To Improve Standardisation Of Care For Patients Admitted To Hospital With Pneumonia, Publisher: AMER THORACIC SOC, ISSN: 1073-449X
Jackson DJ, Trujillo-Torralbo M-B, Shamji B, et al., 2013, Sampling Airway Mucosal Lining Fluid Identifies Roles For Il-33 And Multiple Inflammatory Pathways In Virus-Induced Asthma Exacerbations, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 187, ISSN: 1073-449X
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- Citations: 1
Qiu YS, Zhu J, Footitt JI, et al., 2013, Histone Deacetylase-2 Expression In Bronchial Mucosa Of Experimental Rhinovirus-Induced Exacerbations Of COPD, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 187, ISSN: 1073-449X
Zhu J, Footitt JI, Qiu YS, et al., 2013, Bronchial Mucosal Inflammatory Responses In Rhinovirus Induced Exacerbations Of Chronic Obstructive Pulmonary Disease, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 187, ISSN: 1073-449X
Mallia P, Footitt J, Sotero R, et al., 2012, Rhinovirus Infection Induces Degradation of Antimicrobial Peptides and Secondary Bacterial Infection in Chronic Obstructive Pulmonary Disease, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 186, Pages: 1117-1124, ISSN: 1073-449X
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- Citations: 190
Sykes A, Edwards MR, Macintyre J, et al., 2012, ROLES OF TLR3, TLR4-AND TLRS7-9 IN INTERFERON INDUCTION IN BRONCHIAL EPITHELIAL CELLS AND PERIPHERAL BLOOD MONONUCLEAR CELLS FROM ASTHMATIC AND NON-ASTHMATIC SUBJECTS, Winter Meeting of the British-Thoracic-Society 2012, Publisher: BMJ PUBLISHING GROUP, Pages: A58-A58, ISSN: 0040-6376
Manalan K, Singanayagam A, Molyneaux PL, et al., 2012, Use of the tuberculin skin test and Tspotfor screening prior to TNF antagonisttherapy identifi es additional patientseligible for chemoprophylaxis comparedto use of risk assessment strategies alone, Winter Meeting of the British Thoracic Society
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Jackson DJ, Trujillo-Torralbo M, Footitt J, et al., 2012, SAMPLING AIRWAY MUCOSAL LINING FLUID IDENTIFIES ROLES FOR IL-33 AND MULTIPLE INFLAMMATORY PATHWAYS IN VIRUS-INDUCED ASTHMA EXACERBATIONS, Winter Meeting of the British-Thoracic-Society 2012, Publisher: BMJ PUBLISHING GROUP, Pages: A3-A3, ISSN: 0040-6376
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- Citations: 1
Connell DW, Reuschl A-K, Wenden C, et al., 2012, MOLECULAR IMMUNODIAGNOSIS OF TB INFECTION: A PILOT STUDY, Winter Meeting of the British-Thoracic-Society 2012, Publisher: BMJ PUBLISHING GROUP, Pages: A5-A5, ISSN: 0040-6376
Jackson DJ, Trujillo-Torralbo M, del-Rosario J, et al., 2012, BASELINE ASTHMA CONTROL AND SEVERITY INFLUENCES THE OUTCOME OF VIRUS-INDUCED ASTHMA EXACERBATIONS, Winter Meeting of the British-Thoracic-Society 2012, Publisher: BMJ PUBLISHING GROUP, Pages: A32-A32, ISSN: 0040-6376
Jackson D, Trujillo-Torralbo M-B, Shamji B, et al., 2012, Nasal and bronchial levels of Th2 cytokines correlate during a virus induced asthma exacerbation, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936
Dhasmana D, Bradley C, Connell D, et al., 2012, Improved and immediate diagnostics in mediastinal sarcoid lymphadenopathy via endobronchial ultrasound and quadruple testing, European Respiratory Society Meeting
Singanayagam A, Burroughs AK, Kon OM, et al., 2012, Adaptation and Antituberculosis Drug-induced Liver Injury Reply, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 186, Pages: 388-389, ISSN: 1073-449X
Navani N, Kon OM, Janes SM, 2012, CT screening for lung cancer: so near, yet so far response, THORAX, Vol: 67, Pages: 652-652, ISSN: 0040-6376
Bothamley G, Lipman M, Kon OM, 2012, Cavitating pulmonary tuberculosis: a global challenge., CLINICAL MEDICINE, Vol: 12, Pages: 299-299, ISSN: 1470-2118
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- Citations: 2
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