Imperial College London
Alternate

Dr Onn Min Kon

Faculty of Medicine, National Heart & Lung Institute

Professor of Respiratory Medicine
 
 
 
//

Contact

 

+44 (0)20 3312 1751onn.kon CV

 
 
//

Location

 

Mint WingSt Mary's Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Berrocal-Almanza:2019:10.1016/S1473-3099(19)30260-9,
author = {Berrocal-Almanza, LC and Harris, R and Lalor, MK and Muzyamba, MC and Were, J and O'Connell, A-M and Mirza, A and Kon, O-M and Lalvani, A and Zenner, D},
doi = {10.1016/S1473-3099(19)30260-9},
journal = {Lancet Infectious Diseases},
pages = {1191--1201},
title = {Effectiveness of pre-entry active tuberculosis and post-entry latent tuberculosis screening in new entrants to the UK: a retrospective, population-based cohort study.},
url = {http://dx.doi.org/10.1016/S1473-3099(19)30260-9},
volume = {19},
year = {2019}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: Evaluating interventions that might lead to a reduction in tuberculosis in high-income countries with a low incidence of the disease is key to accelerate progress towards its elimination. In such countries, migrants are known to contribute a large proportion of tuberculosis cases to the burden. We assessed the effectiveness of screening for active tuberculosis before entry to the UK and for latent tuberculosis infection (LTBI) post-entry for reduction of tuberculosis in new-entrant migrants to the UK. Additionally, we investigated the effect of access to primary care on tuberculosis incidence in this population. METHODS: We did a retrospective, population-based cohort study of migrants from 66 countries who were negative for active tuberculosis at pre-entry screening between Jan 1, 2011, and Dec 31, 2014, and eligible for LTBI screening. We used record linkage to track their first contact with primary care, uptake of LTBI screening, and development of active tuberculosis in England, Wales, and Northern Ireland. To assess the effectiveness of the pre-entry screening programme, we identified a control group of migrants who were not screened for active tuberculosis using the specific code for new entrants to the UK registering in primary care within the National Health Service patient registration data system. Our primary outcome was development of active tuberculosis notified to the National Enhanced Tuberculosis Surveillance System. FINDINGS: Our cohort comprised 224234 migrants who were screened for active tuberculosis before entry to the UK and a control group of 118738 migrants who were not. 103990 (50%) migrants who were screened for active tuberculosis registered in primary care; all individuals in the control group were registered in primary care. 1828 tuberculosis cases were identified during the cohort time, of which 31 were prevalent. There were 26 incident active tuberculosis cases in migrants with no evidence of primary care registration, an
AU  - Berrocal-Almanza,LC
AU  - Harris,R
AU  - Lalor,MK
AU  - Muzyamba,MC
AU  - Were,J
AU  - O'Connell,A-M
AU  - Mirza,A
AU  - Kon,O-M
AU  - Lalvani,A
AU  - Zenner,D
DO  - 10.1016/S1473-3099(19)30260-9
EP  - 1201
PY  - 2019///
SN  - 1473-3099
SP  - 1191
TI  - Effectiveness of pre-entry active tuberculosis and post-entry latent tuberculosis screening in new entrants to the UK: a retrospective, population-based cohort study.
T2  - Lancet Infectious Diseases
UR  - http://dx.doi.org/10.1016/S1473-3099(19)30260-9
UR  - https://www.ncbi.nlm.nih.gov/pubmed/31471131
UR  - https://www.sciencedirect.com/science/article/pii/S1473309919302609?via%3Dihub
UR  - http://hdl.handle.net/10044/1/73228
VL  - 19
ER  -
Download