Imperial College London
Alternate

Dr Onn Min Kon

Faculty of Medicine, National Heart & Lung Institute

Professor of Respiratory Medicine
 
 
 
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Contact

 

+44 (0)20 3312 1751onn.kon CV

 
 
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Location

 

Mint WingSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Dhariwal:2014:10.1378/chest.13-2220,
author = {Dhariwal, J and Tennant, RC and Hansell, DM and Westwick, J and Walker, C and Ward, SP and Pride, N and Barnes, PJ and Kon, OM and Hansel, TT and Deceased},
doi = {10.1378/chest.13-2220},
journal = {Chest},
pages = {1006--1015},
title = {Smoking cessation in COPD causes a transient improvement in spirometry and decreases micronodules on high-resolution CT imaging.},
url = {http://dx.doi.org/10.1378/chest.13-2220},
volume = {145},
year = {2014}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: Smoking cessation is of major importance for all smokers; however, in patients with COPD, little information exists on how smoking cessation influences lung function and high-resolution CT (HRCT) scan appearances. METHODS: In this single-center study, we performed screening spirometry in a group of heavy smokers aged 40 to 80 years (N = 358). We then studied the effects of smoking cessation in two groups of selected subjects: smokers with COPD (n = 38) and smokers with normal spirometry (n = 55). In parallel to subjects undergoing smoking cessation, we studied a control group of nonsmokers (n = 19). RESULTS: Subjects with COPD who quit smoking had a marked, but transient improvement in FEV1 at 6 weeks (184 mL, n = 17, P < .01) that was still present at 12 weeks (81 mL, n = 17, P < .05) and only partially maintained at 1 year. In contrast, we saw improvement in the transfer factor of lung for carbon monoxide at 6 weeks in both subjects with COPD who quit smoking (0.47 mmol/min/kPa, n = 17, P < .01) and subjects who quit smoking with normal spirometry (0.40 mmol/min/kPa, n = 35, P < .01). An upper-zone single HRCT image slice reliably identified emphysema at baseline in 74% of smokers with COPD (28 of 38) and 29% of healthy smokers (16 of 55). Smoking cessation had no significant effect on the appearances of emphysema but decreased the presence of micronodules on HRCT imaging. CONCLUSIONS: Cigarette smoking causes extensive lung function and HRCT image abnormalities, even in patients with normal spirometry. Smoking cessation has differential effects on lung function (FEV1 and gas transfer) and features on HRCT images (emphysema and micronodules). Cessation of smoking in patients with COPD causes a transient improvement in FEV1 and decreases the presence of micronodules, offering an opportunity for concomitant therapy during smoking cessation to augment these effects. Smoking cessation at the earliest possible opportunity is vita
AU  - Dhariwal,J
AU  - Tennant,RC
AU  - Hansell,DM
AU  - Westwick,J
AU  - Walker,C
AU  - Ward,SP
AU  - Pride,N
AU  - Barnes,PJ
AU  - Kon,OM
AU  - Hansel,TT
AU  - Deceased
DO  - 10.1378/chest.13-2220
EP  - 1015
PY  - 2014///
SP  - 1006
TI  - Smoking cessation in COPD causes a transient improvement in spirometry and decreases micronodules on high-resolution CT imaging.
T2  - Chest
UR  - http://dx.doi.org/10.1378/chest.13-2220
UR  - https://www.ncbi.nlm.nih.gov/pubmed/24522562
VL  - 145
ER  -
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