Imperial College London
Alternate

Dr Onn Min Kon

Faculty of Medicine, National Heart & Lung Institute

Professor of Respiratory Medicine
 
 
 
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Contact

 

+44 (0)20 3312 1751onn.kon CV

 
 
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Location

 

Mint WingSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Jha:2015,
author = {Jha, A and Kon, OM},
journal = {Minerva Pneumologica},
pages = {85--101},
title = {Overview of pulmonary, pleural and mediastinal investigations in active tuberculosis},
url = {http://www.minervamedica.it/en/journals/minerva-pneumologica/article.php?cod=R16Y2015N02A0085},
volume = {54},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Tuberculosis (TB) in Europe remains an important source of morbidity and with a notification rate of up to 85 per 100,000 of the population in some European Union (EU) countries, the need for accurate and earlydiagnosis is crucial. Spontaneous sputum sampling for obtaining cultures remains the commonest method for diagnosing pulmonarytuberculosis, whilst the introduction of the Gene Xpert MTB/RIF test may offer a more rapid and sensitive option to the traditional smear due to its ability to simultaneously diagnose Mycobacterium tuberculosisand identify Rifampicin resistant strains with great accuracy. Standard and high resolution computed tomography (HRCT), as well as positron emission tomography (PET) scanning are becoming important tools forsmear negative cases or those with complex presentations. The difficulties of diagnosing pleural TB have been improved with theadvent of specific and non-specific immune markers such as adenosine deaminase (ADA) and interferon gamma (IFN-γ), as well as by the ability to obtain highly accurate biopsies with thoracoscopy. Mediastinal and hilar lymphadenitis is a common presentationof the disease and endobronchial ultrasound with transbronchial needle aspiration (EBUSTBNA) is a safe and highly sensitive procedurewhich is rapidly establishing itself as a first line tool in the diagnosis of intrathoracic TB. In this review we outline the host and environmental factors that contribute to the propagation of pulmonary tuberculosis.
AU  - Jha,A
AU  - Kon,OM
EP  - 101
PY  - 2015///
SN  - 0026-4954
SP  - 85
TI  - Overview of pulmonary, pleural and mediastinal investigations in active tuberculosis
T2  - Minerva Pneumologica
UR  - http://www.minervamedica.it/en/journals/minerva-pneumologica/article.php?cod=R16Y2015N02A0085
VL  - 54
ER  -
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