Imperial College London
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ProfessorPaulAbel

Faculty of Medicine, Department of Surgery & Cancer

Emeritus Professor of Urology
 
 
 
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Contact

 

+44 (0)20 3313 2268p.abel

 
 
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Location

 

BN2/11Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

200 results found

BASHIR I, SIKORA K, ABEL P, FOSTER CSet al., 1994, ESTABLISHMENT AND IN-VIVO CHARACTERIZATION OF MULTIDRUG-RESISTANT DUNNING R3327 RAT PROSTATE-CARCINOMA CELL-LINES, INTERNATIONAL JOURNAL OF CANCER, Vol: 57, Pages: 719-726, ISSN: 0020-7136

Journal article

ABEL PD, 1994, FOLLOW-UP OF PATIENTS WITH SUPERFICIAL TRANSITIONAL-CELL CARCINOMA OF THE BLADDER - REPLY, BRITISH JOURNAL OF UROLOGY, Vol: 73, Pages: 333-334, ISSN: 0007-1331

Journal article

DAGNELIE PC, BELL JD, WILLIAMS SCR, BATES TE, ABEL PD, FOSTER CSet al., 1994, EFFECT OF FISH-OIL ON CANCER CACHEXIA AND HOST LIVER-METABOLISM IN RATS WITH PROSTATE TUMORS, LIPIDS, Vol: 29, Pages: 195-203, ISSN: 0024-4201

Journal article

Brawn PN, Johnson EH, Speights VO, Riggs M, Kuhl D, Abel PD, Lind M, Bell Net al., 1994, Incidence, racial differences, and prognostic significance of prostate carcinomas diagnosed with obstructive symptoms, Cancer, Vol: 74, Pages: 1607-1611, ISSN: 0008-543X

Background. It is unknown how often prostate carcinomas are diagnosed as a result of urinary obstructive symptoms or whether prostate carcinomas diagnosed because of obstructive symptoms have a favorable or unfavorable prognosis. It is also unknown whether racial differences in obstructive symptoms could help explain why black men with prostate carcinoma are diagnosed with more advanced stages and grades of prostate carcinoma than are white men with prostate carcinoma. Method. At a single Veterans Administration Medical Center, 478 consecutive cases of prostate carcinoma diagnosed between 1973 and 1985 were identified. The incidence of obstructive symptoms at diagnosis, racial differences in obstructive symptoms, and the survival of patients with and without obstructive symptoms, stratified by stage and grade, were determined. In addition, racial differences in the frequency of surgical intervention required to relieve the obstructive symptoms were determined. Results. All patients diagnosed with Stage A prostate carcinoma and most (82%) patients diagnosed with Stage C prostate carcinoma had obstructive symptoms. Those diagnosed with Stage B and Stage D prostate carcinomas had with similar frequencies (53% and 55%, respectively) of obstructive symptoms. Survival, stratified by stage and grade, was similar for men with and without obstructive symptoms. The incidences of obstructive symptoms and the frequency of surgical intervention to relieve the obstructive symptoms, stage for stage, were similar for white and black men. Conclusion. Survival, stratified by stage and grade, is not affected adversely by obstructive symptoms. Neither racial differences in the incidence of obstructive symptoms nor the frequency with which obstructive symptoms require surgical correction explain why black men with CAP consistently are diagnosed more frequently with Stage D prostate carcinoma and less frequently with Stage A CAP than white men with CAP. Copyright © 1994 American Can

Journal article

DAVIES B, WAXMAN J, WASAN H, ABEL P, WILLIAMS G, KRAUSZ T, NEAL D, THOMAS D, HANBY A, BALKWILL Fet al., 1993, LEVELS OF MATRIX METALLOPROTEASES IN BLADDER-CANCER CORRELATE WITH TUMOR GRADE AND INVASION, CANCER RESEARCH, Vol: 53, Pages: 5365-5369, ISSN: 0008-5472

Journal article

ABEL PD, LINDSAY KS, LORD RHH, MACGREGOR S, FLOYD I, WILLIAMS G, PUSEY CDet al., 1993, EFFECTS OF PLASMA-EXCHANGE ON SPERM ANTIBODY-LEVELS IN MALES WITH SUBFERTILITY, BRITISH JOURNAL OF UROLOGY, Vol: 72, Pages: 820-821, ISSN: 0007-1331

Journal article

ABEL PD, 1993, FOLLOW-UP OF PATIENTS WITH SUPERFICIAL TRANSITIONAL-CELL CARCINOMA OF THE BLADDER - THE CASE FOR A CHANGE IN POLICY, BRITISH JOURNAL OF UROLOGY, Vol: 72, Pages: 135-142, ISSN: 0007-1331

Journal article

Zafar F, Thompson JN, Pati J, Kiely EA, Abel PDet al., 1993, Sutureless circumcision., Br J Surg, Vol: 80, ISSN: 0007-1323

Journal article

DAGNELIE PC, BELL JD, WILLIAMS SCR, BATES TE, ABEL PD, FOSTER CSet al., 1993, ALTERED PHOSPHORYLATION STATUS, PHOSPHOLIPID-METABOLISM AND GLUCONEOGENESIS IN THE HOST LIVER OF RATS WITH PROSTATE-CANCER - A P-31 MAGNETIC-RESONANCE SPECTROSCOPY STUDY, BRITISH JOURNAL OF CANCER, Vol: 67, Pages: 1303-1309, ISSN: 0007-0920

Journal article

ABEL PD, 1993, SUPERFICIAL BLADDER-CANCER, BRITISH MEDICAL JOURNAL, Vol: 306, Pages: 1480-1480, ISSN: 0959-8138

Journal article

ABEL PD, LINDSAY KS, LORD RHH, MacGREGOR S, FLOYD I, WILLIAMS G, PUSEY CDet al., 1993, Effects of Plasma Exchange on Sperm Antibody Levels in Males with Subfertility, British Journal of Urology, Vol: 72, Pages: 820-821, ISSN: 0007-1331

Summary Three men with subfertility secondary to sperm antibodies with measurable serum sperm antibody levels underwent a course of 3 plasma exchanges over a period of 1 week. The levels of serum anti‐sperm antibodies fell by a mean of 3.3 dilutions. This fall was maintained for approximately 4 weeks, after which there was a return to the original levels. Plasma exchange is time‐consuming and relatively expensive but it offers a possible alternative to steroid treatment (with its potential side effects) in men with sperm antibodies and warrants further investigation. © 1993 British Journal of Urology

Journal article

McLoughlin J, Foster CS, Price P, Williams G, Abel PDet al., 1993, Evaluation of Ki-67 monoclonal antibody as prognostic indicator for prostatic carcinoma, Br J Urol, Vol: 72, Pages: 92-97

Prostate tissue containing either primary adenocarcinoma (45 patients) or benign hyperplasia (15 patients) was immunostained with the monoclonal antibody Ki-67, which recognises a human nuclear antigen expressed by human cycling cells. The percentage of cells staining positive was considered a measure of proliferation. This derived Ki-67 index was higher for carcinomas than for hyperplastic glands. Within the group of carcinomas, Ki-67 indices in patients with metastatic disease were significantly higher than in those without and there was a trend towards increasing Ki-67 indices with increasing Gleason grade. When patients with prostate cancer were prospectively followed up, the Ki-67 index did not predict either disease progression or hormone responsiveness. Ki-67 immunostaining may define a group of patients with prostate cancer of poor prognosis.

Journal article

FOSTER CS, ABEL PD, 1992, CLINICAL AND MOLECULAR TECHNIQUES FOR DIAGNOSIS AND MONITORING OF PROSTATIC-CANCER, HUMAN PATHOLOGY, Vol: 23, Pages: 395-401, ISSN: 0046-8177

Journal article

FOSTER CS, MCLOUGHLIN J, BASHIR I, ABEL PDet al., 1992, MARKERS OF THE METASTATIC PHENOTYPE IN PROSTATE-CANCER, HUMAN PATHOLOGY, Vol: 23, Pages: 381-394, ISSN: 0046-8177

Journal article

Waxman J, Barton C, Biruls R, James N, Harrison M, Rogers H, Mee D, Sikora K, Colbeck R, Abel Pet al., 1992, Bladder cancer: inter-relationships between chemotherapy and radiotherapy., Br J Urol, Vol: 69, Pages: 151-155, ISSN: 0007-1331

There has been increasing interest in the role of chemotherapy as primary treatments for patients with urothelial cancer and because of the poor prognosis of locally advanced tumours with conventional treatment, trials have been initiated comparing radiotherapy with chemotherapy as primary therapies. In this context it is important to assess the relationship between the responses to chemotherapy and radiotherapy, and this we have examined in 64 patients treated with MVMJ (methotrexate, vinblastine, mitozantrone and carboplatin). Either a complete or a partial response was found in 29 of the 64 patients, 15 had stable disease and 13 had progression of disease. Seven patients died within the first treatment month. The survival of the responding patients ranged from 114 to 1184 days. Six of 15 patients who had had pelvic irradiation prior to chemotherapy responded to MVMJ, the maximum duration of response being more than 3 years. Twenty-two patients had radiotherapy following their chemotherapy. One of 13 patients not responding to MVMJ had a transient response to radical radiotherapy. Only 1 of 9 patients responding to chemotherapy and then relapsing responded to subsequent radical radiotherapy. Patients with metastatic disease or with recurrent disease after radiotherapy have a worthwhile chance of responding to chemotherapy and achieve durable remissions. In contrast, radiotherapy appears relatively ineffective in patients whose disease progresses or relapses after chemotherapy given as primary treatment with curative intent.

Journal article

THORPE SJ, ABEL P, 1991, DETECTION OF BLOOD GROUP-A AND H-RELATED ANTIGENS IN NORMAL AND NEOPLASTIC BLADDER EPITHELIUM - A COMPARATIVE-STUDY USING MONOCLONAL-ANTIBODIES WITH DEFINED FINE SPECIFICITIES, INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, Vol: 72, Pages: 129-138, ISSN: 0959-9673

Journal article

MCLOUGHLIN J, BRAWN P, ABEL PD, WILLIAMS G, FOSTER CSet al., 1991, LECTIN-BINDING PATTERNS OF PRIMARY PROSTATIC CANCERS AND THEIR CORRESPONDING LYMPH-NODE METASTASES, JOURNAL OF PATHOLOGY, Vol: 163, Pages: A157-A157, ISSN: 0022-3417

Journal article

Ohri SK, Abel PD, 1991, Review article: The pathophysiology of nephrourological complications following cardiopulmonary bypass, Perfusion, Vol: 6, Pages: 79-91, ISSN: 0267-6591

The development of urethral strictures, as in the nonbypass patient, is multifactorial. Ischaemia has been demonstrated as one of the risk factors for urethral mucosal damage. There is still not sufficient evidence to support the routine use of suprapubic catheterization with its attendant risks, but preference should be given to the use of silicone catheters for patients undergoing cardiopulmonary bypass. © 1991, Sage Publications. All rights reserved.

Journal article

QAYUM A, GULLICK W, ABEL P, WILLIAMS G, MELON K, NEAL D, SIKORA K, WAXMAN Jet al., 1990, DIRECT EFFECTS OF GNRH ANALOGS IN PROSTATIC-CANCER, BRITISH JOURNAL OF CANCER, Vol: 62, Pages: 531-531, ISSN: 0007-0920

Journal article

ABEL PD, FOSTER CS, TEBBUTT S, WILLIAMS Get al., 1990, DIFFERENCES IN EXPRESSION OF OLIGOSACCHARIDE DETERMINANTS BY PHENOTYPICALLY DISTINCT SUBLINES OF THE DUNNING 3327 RAT PROSTATE-CANCER, JOURNAL OF UROLOGY, Vol: 144, Pages: 760-765, ISSN: 0022-5347

Journal article

MCLOUGHLIN J, GILL KP, ABEL PD, WILLIAMS Get al., 1990, SYMPTOMS VERSUS FLOW-RATES VERSUS URODYNAMICS IN THE SELECTION OF PATIENTS FOR PROSTATECTOMY, BRITISH JOURNAL OF UROLOGY, Vol: 66, Pages: 303-305, ISSN: 0007-1331

Journal article

MCLOUGHLIN J, ABEL PD, SHAIKH N, WATERS J, WILLIAMS Get al., 1990, VISUAL ANALOG SCALES DISTINGUISH BETWEEN LOW URINARY FLOW-RATES DUE TO IMPAIRED DETRUSOR CONTRACTILITY AND THOSE DUE TO BLADDER OUTFLOW OBSTRUCTION, BRITISH JOURNAL OF UROLOGY, Vol: 66, Pages: 16-18, ISSN: 0007-1331

Journal article

MCLOUGHLIN J, JAGER R, ABEL PD, ELDIN A, ADAM A, WILLIAMS Get al., 1990, THE USE OF PROSTATIC STENTS IN PATIENTS WITH URINARY RETENTION WHO ARE UNFIT FOR SURGERY - AN INTERIM-REPORT, BRITISH JOURNAL OF UROLOGY, Vol: 66, Pages: 66-70, ISSN: 0007-1331

Journal article

WILLIAMS G, ASOPA R, ABEL PD, SMITH Cet al., 1990, PITUITARY-ADRENAL AND GONADAL ENDOCRINE SUPPRESSION FOR THE PRIMARY-TREATMENT OF PROSTATE-CANCER, BRITISH JOURNAL OF UROLOGY, Vol: 65, Pages: 504-508, ISSN: 0007-1331

Journal article

ABEL PD, FOSTER CS, TEBBUTT S, WILLIAMS Get al., 1990, A STUDY OF OLIGOSACCHARIDE DETERMINANTS EXPRESSED BY PROSTATIC GLANDULAR EPITHELIUM OF THE NORMAL ADULT-RAT, UROLOGICAL RESEARCH, Vol: 18, Pages: 233-237, ISSN: 0300-5623

Journal article

ABEL PD, MCCORMACK TT, 1990, COMPLICATED PEPTIC-ULCERATION IN A CHILD, BRITISH JOURNAL OF CLINICAL PRACTICE, Vol: 44, Pages: 159-160, ISSN: 0007-0947

Journal article

WAXMAN J, SANDOW J, ABEL P, BARTON C, KEANE P, WILLIAMS Get al., 1990, 3-MONTHLY GNRH AGONIST (BUSERELIN) FOR PROSTATIC-CANCER, BRITISH JOURNAL OF UROLOGY, Vol: 65, Pages: 43-45, ISSN: 0007-1331

Journal article

MCLOUGHLIN J, ABEL PD, 1989, GRADING OF CERVICAL INTRAEPITHELIAL NEOPLASIA, BRITISH MEDICAL JOURNAL, Vol: 298, Pages: 1383-1383, ISSN: 1756-1833

Journal article

WAXMAN JH, SANDOW J, ABEL P, FARAH N, ODONOGHUE EPN, FLEMING J, COX J, SIKORA K, WILLIAMS Get al., 1989, 2-MONTHLY DEPOT GONADOTROPIN-RELEASING HORMONE AGONIST (BUSERELIN) FOR TREATMENT OF PROSTATIC-CANCER, ACTA ENDOCRINOLOGICA, Vol: 120, Pages: 315-318, ISSN: 0001-5598

Journal article

ABEL PD, KEANE P, LEATHEM A, TEBBUTT S, WILLIAMS Get al., 1989, CHANGE IN GLYCOCONJUGATE FOR THE BINDING-SITE OF THE LECTIN ULEX-EUROPEUS 1 FOLLOWING MALIGNANT TRANSFORMATION OF PROSTATIC EPITHELIUM, BRITISH JOURNAL OF UROLOGY, Vol: 63, Pages: 183-185, ISSN: 0007-1331

Journal article

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