Imperial College London
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ProfessorPaulAylin

Faculty of Medicine, School of Public Health

Professor of Epidemiology and Public Health
 
 
 
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Contact

 

p.aylin Website

 
 
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Location

 

Reynolds BuildingCharing Cross Campus

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Summary

 

Publications

Citation

BibTex format

@article{Dewa:2021:10.1186/s13643-021-01798-z,
author = {Dewa, L and Kalniunas, A and Orleans-Foli, S and Pappa, S and Aylin, P},
doi = {10.1186/s13643-021-01798-z},
journal = {Systematic Reviews},
pages = {1--8},
title = {Detecting signs of deterioration in young patients with serious mental illness: a systematic review},
url = {http://dx.doi.org/10.1186/s13643-021-01798-z},
volume = {10},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundSerious mental illnesses (SMI) such as schizophrenia and bipolar disorder first develop between ages 14-25. Once diagnosed, young peoples’ health can deteriorate, and it is therefore vital to detect this early to prevent severe outcomes including hospitalisations and deaths by suicide. The main study aim is to describe and discuss observational studies that examine signs of deterioration in young patients with SMI. MethodsA systematic review guided by the published protocol was conducted. Cumulative Index to Nursing and allied Health Literature (CINAHL), MEDLINE, Embase, PsycINFO, Health Management Information Consortium (HMIC) and Web of Science were searched against pre-defined criteria until March 1st 2021. Observational studies were extracted according to design, country, participant, indicator, outcome and main finding categories. Quality was assessed independently using the Newcastle Ottawa Scale (NOS). ResultsOf the 15788 publications identified, 5 studies were included and subjected to narrative synthesis. Two indicators of mental health deterioration were identified: cognitive functioning (decline, worsening and poor school/academic performance) and expressed emotion status. Indicators revealed mixed views on predicting deterioration. Worsening cognitive functioning and expressed emotion status significantly predicted medication non-adherence and relapse respectively. However, a decline in cognitive functioning (poor academic performance) was not found to significantly correlate to deaths by suicide. Study quality was mostly poor and associations between indicators and varied outcomes were weak. The heterogeneous nature of the data made comparisons difficult and did not allow for further statistical analysis. ConclusionTo our knowledge, this is the first review of observational studies to identify indicators of deterioration in young patients with SMI. Worsening cognitive functioning and expressed emotion status could indicate non-adherence
AU  - Dewa,L
AU  - Kalniunas,A
AU  - Orleans-Foli,S
AU  - Pappa,S
AU  - Aylin,P
DO  - 10.1186/s13643-021-01798-z
EP  - 8
PY  - 2021///
SN  - 2046-4053
SP  - 1
TI  - Detecting signs of deterioration in young patients with serious mental illness: a systematic review
T2  - Systematic Reviews
UR  - http://dx.doi.org/10.1186/s13643-021-01798-z
UR  - https://systematicreviewsjournal.biomedcentral.com/articles/10.1186/s13643-021-01798-z
UR  - http://hdl.handle.net/10044/1/91539
VL  - 10
ER  -
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