Imperial College London
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ProfessorPaulAylin

Faculty of Medicine, School of Public Health

Professor of Epidemiology and Public Health
 
 
 
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Contact

 

p.aylin Website

 
 
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Location

 

Reynolds BuildingCharing Cross Campus

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Summary

 

Publications

Citation

BibTex format

@unpublished{Glampson:2021:10.2196/preprints.30010,
author = {Glampson, B and Brittain, J and Kaura, A and Mulla, A and Mercuri, L and Brett, SJ and Aylin, P and Sandall, T and Goodman, I and Redhead, J and Saravanakumar, K and Mayer, EK},
doi = {10.2196/preprints.30010},
publisher = {JMIR Publications},
title = {Assessing COVID-19 vaccine uptake and effectiveness through the north west London vaccination program: retrospective cohort study},
url = {http://dx.doi.org/10.2196/preprints.30010},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - UNPB
AB  - Background:Real world data supporting the effectiveness of the COVID-19 vaccination strategy in the UK population is needed to guide health policy. This real-word data-driven evidence study of the UK COVID-19 Vaccination Programme in the Northwest London (NWL) population used a unique dataset established as part of the Gold Command Covid-19 response in NWL (iCARE https://imperialbrc.nihr.ac.uk/facilities/icare/), which included the pre-established Whole System Integrated Care (WSIC) data collated for the purposes of population health in the sector.Objective:To assess the early vaccine administration coverage and vaccine effectiveness and outcome data across an integrated care system of eight CCGs leveraging a unique population-level care datasetMethods:Design - Retrospective cohort study. Setting - Individuals eligible for COVID 19 vaccination in North West London based on linked primary and secondary care data. Participants - 2,183,939 individuals eligible for COVID 19 vaccinationResults:During the NWL vaccine programme study time period 5.88% of individuals declined and did not receive a vaccination. Black or black British individuals had the highest rate of declining a vaccine at 16.14% (4,337). There was a strong negative association between deprivation and rate of declining vaccination (r=-0.94, p<0.01) with 13.5% of individuals declining vaccination in the most deprived postcodes compared to 0.98% in the least deprived postcodes. In the first six days after vaccination 344 of 389587 individuals tested positive for COVID-19 (0.09%). The rate increased to 0.13% (525/389,243) between days 7 and 13, before then gradually falling week on week. At 28 days post vaccination there was a 74% (HR 0.26 (0.19-0.35)) and 78% (HR 0.22 (0.18-0.27)) reduction in risk of testing positive for COVID -19 for individuals that received the Oxford/Astrazeneca and Pfizer/BioNTech vaccines respectively, when compared with unvaccinated individuals. After vaccination very low rates of
AU  - Glampson,B
AU  - Brittain,J
AU  - Kaura,A
AU  - Mulla,A
AU  - Mercuri,L
AU  - Brett,SJ
AU  - Aylin,P
AU  - Sandall,T
AU  - Goodman,I
AU  - Redhead,J
AU  - Saravanakumar,K
AU  - Mayer,EK
DO  - 10.2196/preprints.30010
PB  - JMIR Publications
PY  - 2021///
TI  - Assessing COVID-19 vaccine uptake and effectiveness through the north west London vaccination program: retrospective cohort study
UR  - http://dx.doi.org/10.2196/preprints.30010
UR  - https://preprints.jmir.org/preprint/30010
UR  - http://hdl.handle.net/10044/1/91825
ER  -
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