Imperial College London
Portrait Picture

ProfessorPhillipBennett

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Clinical Professor
 
 
 
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Contact

 

+44 (0)20 7594 2176p.bennett

 
 
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Assistant

 

Miss Kiran Dosanjh +44 (0)20 7594 2176

 
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Location

 

Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Kalliala:2020:10.1016/j.annonc.2019.11.004,
author = {Kalliala, I and Athanasiou, A and Veroniki, AA and Salanti, G and Efthimiou, O and Raftis, N and Bowden, S and Paraskevaidi, M and Aro, K and Arbyn, M and Bennett, P and Nieminen, P and Paraskevaidis, E and Kyrgiou, M},
doi = {10.1016/j.annonc.2019.11.004},
journal = {Annals of Oncology},
pages = {213--227},
title = {Incidence and mortality from cervical cancer and other malignancies after treatment of cervical intraepithelial neoplasia: a systematic review and meta-analysis of the literature.},
url = {http://dx.doi.org/10.1016/j.annonc.2019.11.004},
volume = {31},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background: While local treatments for cervical intraepithelial neoplasia (CIN) are highly effective, it has been reported that treated women remain at increased risk of cervical and other cancers. Our aim is to explore the risk of developing or dying from cervical cancer and other HPV- and non-HPV-related malignancies after CIN treatment and infer about its magnitude compared to general population.Materials and methods:Design: Systematic review and meta-analysis.Eligibility criteria: Studies with registry-based follow-up reporting cancer incidence or mortality after CIN treatment. Data synthesis: Summary effects were estimated using random-effects models.Outcomes: Incidence rate of cervical cancer among women treated for CIN (per 100,000 woman-years). Relative risk (RR) of cervical cancer, other HPV-related anogenital tract cancer (vagina, vulva, anus), any cancer, and mortality, for women treated with CIN versus the general population.Results:  Twenty-seven studies were eligible. The incidence rate for cervical cancer after CIN treatment was 39 per 100,000 woman-years (95% CI 22 to 69). RR of cervical cancer was elevated compared to the general population (3·30, 2·57 to 4·24; P<0·001). RR was higher for women over 50 years old and remained elevated for at least 20 years after treatment. RR of  vaginal (10·84, 5·58 to 21·10; P<0·001), vulvar (3·34, 2·39 to 4·67; P<0·001), and anal cancer (5·11, 2·73 to 9·55; P<0·001) was also higher. Mortality from cervical/vaginal cancer was elevated, but our estimate was more uncertain (RR 5·04, 0·69 to 36·94; P=0·073).Conclusions: Women treated for CIN have considerably higher risk to be later diagnosed with cervical and other HPV-related cancers compared to general population. The higher risk of cervical cancer lasts for at least 20 years after treatment and is higher for women
AU  - Kalliala,I
AU  - Athanasiou,A
AU  - Veroniki,AA
AU  - Salanti,G
AU  - Efthimiou,O
AU  - Raftis,N
AU  - Bowden,S
AU  - Paraskevaidi,M
AU  - Aro,K
AU  - Arbyn,M
AU  - Bennett,P
AU  - Nieminen,P
AU  - Paraskevaidis,E
AU  - Kyrgiou,M
DO  - 10.1016/j.annonc.2019.11.004
EP  - 227
PY  - 2020///
SN  - 0923-7534
SP  - 213
TI  - Incidence and mortality from cervical cancer and other malignancies after treatment of cervical intraepithelial neoplasia: a systematic review and meta-analysis of the literature.
T2  - Annals of Oncology
UR  - http://dx.doi.org/10.1016/j.annonc.2019.11.004
UR  - https://www.sciencedirect.com/science/article/pii/S0923753419390854?via%3Dihub
UR  - http://hdl.handle.net/10044/1/74863
VL  - 31
ER  -
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