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@inbook{MacIntyre:2020,
author = {MacIntyre, D and Bennett, P},
booktitle = {The Human Microbiome in Early Life Implications to Health and Disease},
publisher = {Academic Press},
title = {Chapter 3 - Microbial signatures of preterm birth},
year = {2020}
}

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TY  - CHAP
AB  - Preterm birth remains the primary cause of death in children under the age of 5 years worldwide. A causal relationship between infection and preterm birth has long been recognized. However, recent applications of molecular-based profiling techniques have provided new insights into the relationship between specific bacterial compositions of the lower reproductive tract and subsequent preterm birth risk. In this chapter, we investigate evidence for “microbial signatures” of preterm birth and examine mechanisms by which shifts in microbiome composition could contribute to an infectious etiology of preterm birth. Despite high levels of heterogeneity between studies, vaginal depletion of Lactobacillus spp. and high-diversity communities enriched for potentially pathogenic bacteria are frequently associated with preterm birth, whereas Lactobacillus spp. dominant communities appear to confer protection against preterm birth, particularly when dominated by Lactobacillus crispatus. Strategies focused toward promoting optimal microbial signatures during pregnancy may help reduce rates of preterm birth and improve maternal and neonatal outcomes.
AU  - MacIntyre,D
AU  - Bennett,P
PB  - Academic Press
PY  - 2020///
SN  - 9780128180976
TI  - Chapter 3 - Microbial signatures of preterm birth
T1  - The Human Microbiome in Early Life Implications to Health and Disease
ER  -

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