Paul Bentley is Clinical Senior Lecturer and Honorary Consultant Neurologist within Centre for Restorative Neurosciences, Imperial College London. After training at Cambridge and UCL, he undertook a research fellowship in Psychology Dept, Harvard, and a PhD in cognitive neuroscience at UCL. He was awarded a Stroke Association Clinical Fellowship and DoH New Blood Award. He is the first UK neurologist to have been dually-accredited in stroke medicine by the Royal College of Physicians.
In order to help any stroke patient recover it is essential to understand how brain damage has affected this particular person, which part of their brain has been affected, and how recovery, and treatments, will be influenced by their individual pattern of injury. In other words, successful stroke treatments are likely to be those that can be personalized, rather than handed out in a “one size fits all” manner. Our group are therefore developing bedside computerized tests and brain scan techniques that can profile patients, and assign them individually to their most appropriate therapy.
Examples of ongoing projects are:
1. Profiling patients according to their attention deficits. Attention deficits occur in more than 50% of stroke patients, and are important to identify, since they can impair recovery of speech and motor disabilities, yet can be potentially targeted with drugs or behavioural therapies. See: MedicalNewsToday Article
2. Establishing a large, multi-centre brain scan database, for the purpose of correlating stroke outcomes with lesion location. See: NatureWorldNews Article.
3. World-first trial of selected CD34+ stem cells in stoke, whilst developing imaging techniques that can monitor cell-homing and revascularization. See: Telegraph Article
et al., 2013, Triple dissociation of attention networks in stroke according to lesion location, Neurology, Vol:81, ISSN:0028-3878, Pages:812-820
et al., 2010, Causal Relationship of Susceptibility Genes to Ischemic Stroke: Comparison to Ischemic Heart Disease and Biochemical Determinants, PLOS One, Vol:5, ISSN:1932-6203
Bentley P, Driver J, Dolan RJ, 2011, Cholinergic modulation of cognition: Insights from human pharmacological functional neuroimaging, Progress in Neurobiology, Vol:94, ISSN:0301-0082, Pages:360-388
McColgan P, Sharma P, Bentley P, 2011, Stem Cell Tracking in Human Trials: A Meta-Regression, Stem Cell Reviews, Vol:7, ISSN:1550-8943, Pages:1031-1040
et al., 2011, CADASIL with cord involvement associated with a novel and atypical NOTCH3 mutation, Journal of Neurology Neurosurgery and Psychiatry, Vol:82, ISSN:0022-3050, Pages:855-860
Bentley P, Driver J, Dolan RJ, 2009, Modulation of fusiform cortex activity by cholinesterase inhibition predicts effects on subsequent memory, Brain, Vol:132, ISSN:0006-8950, Pages:2356-2371
Bentley P, Driver J, Dolan RJ, 2008, Cholinesterase inhibition modulates visual and attentional brain responses in Alzheimer's disease and health, Brain, Vol:131, ISSN:0006-8950, Pages:409-424
Bentley P, Husain M, Dolan RJ, 2004, Effects of cholinergic enhancement on visual stimulation, spatial attention, and spatial working memory., Neuron, Vol:6, Pages:969-982