Paul Bentley is Clinical Director of the Imperial College Network Of Excellence in Rehabilitation Technology; Clinical Founder of Gripable Ltd.; Clinical Senior Lecturer and Honorary Consultant Neurologist within Brain Sciences, Imperial College London. After training at Cambridge and UCL, he undertook a research fellowship in Psychology Dept, Harvard, and a PhD in cognitive neuroscience at UCL. He is the first UK neurologist to have been dually-accredited in stroke medicine by the Royal College of Physicians. His research into translational AI and robotics for stroke has been credited in recent years by The Lancet Editorial; UK Chief Medical Officer Annual Report; the UK Ministry for Innovation in the Dept of Health & Social Care; and acknowledged by numerous prizes including from NHS England and UK Stroke Association. He currently leads on a NIHR-funded project developing a social therapy network for remote-interactive physiotherapy.
Successful stroke treatments are likely to be those that can be personalized, depending upon factors such as lesion anatomy, premorbid status, and cognitive ability. At the same time they need to be practical, accessible and affordable. Our group are developing bedside computerized tests, devices and neuroimaging techniques that can profile patients, and assign them individually to their optimal acute and restorative therapies.
Examples of ongoing projects are:
1. Developing technologies enabling self-administered physiotherapy (gripAble) in conjunction with the Human Robotics Group Imperial College, for patients requiring physical and cognitive rehabilitation. See: The Sun Article; CBS News Video, MedicalNewsToday Article
2. Establishing a large, multi-centre brain imaging database, in conjunction with the Biomedical Imaging Analysis Group at Imperial College, for the purpose of predicting stroke outcome. See: NatureWorldNews Article.
3. World-first trial of selected CD34 stem cells in stoke, whilst developing imaging techniques that can monitor cell-homing and revascularization. See: Telegraph Article
et al., 2018, Rapid automated quantification of cerebral leukoaraiosis on CT: a multicentre validation study, Radiology, Vol:288, ISSN:0033-8419, Pages:573-581
et al., 2017, Motor dexterity and strength depend upon integrity of the attention-control system, Proceedings of the National Academy of Sciences of the United States of America, Vol:115, ISSN:0027-8424, Pages:E536-E545
et al., 2013, Triple dissociation of attention networks in stroke according to lesion location, Neurology, Vol:81, ISSN:0028-3878, Pages:812-820
Bentley P, Driver J, Dolan RJ, 2011, Cholinergic modulation of cognition: Insights from human pharmacological functional neuroimaging, Progress in Neurobiology, Vol:94, ISSN:0301-0082, Pages:360-388
et al., 2011, CADASIL with cord involvement associated with a novel and atypical NOTCH3 mutation, Journal of Neurology Neurosurgery and Psychiatry, Vol:82, ISSN:0022-3050, Pages:855-860
McColgan P, Sharma P, Bentley P, 2011, Stem Cell Tracking in Human Trials: A Meta-Regression, Stem Cell Rev Reports
et al., 2010, Causal relationship of susceptibility genes to ischemic stroke: comparison to ischemic heart disease and biochemical determinants., PLOS One, Vol:5, ISSN:1932-6203, Pages:e9136(1)-e9136(15)
Bentley P, Driver J, Dolan RJ, 2009, Modulation of fusiform cortex activity by cholinesterase inhibition predicts effects on subsequent memory, Brain, Vol:132, ISSN:0006-8950, Pages:2356-2371
Bentley P, Driver J, Dolan RJ, 2008, Cholinesterase inhibition modulates visual and attentional brain responses in Alzheimer's disease and health, Brain, Vol:131, ISSN:0006-8950, Pages:409-424