Paul Bentley is Clinical Senior Lecturer and Honorary Consultant Neurologist within Centre for Restorative Neurosciences, Imperial College London. After training at Cambridge and UCL, he undertook a research fellowship in Psychology Dept, Harvard, and a PhD in cognitive neuroscience at UCL. He was awarded a Stroke Association Clinical Fellowship and DoH New Blood Award. He is the first UK neurologist to have been dually-accredited in stroke medicine by the Royal College of Physicians.
Successful stroke treatments are likely to be those that can be personalized, depending upon factors such as lesion anatomy, premorbid status, and cognitive ability. At the same time they need to be practical, accessible and affordable. Our group are developing bedside computerized tests, devices and neuroimaging techniques that can profile patients, and assign them individually to their optimal acute and restorative therapies.
Examples of ongoing projects are:
1. Developing a portable hand-and-brain trainer (gripAble) in conjunction with the Human Robotics Group Imperial College, for patients requiring physical and cognitive rehabilitation. See: The Sun Article; CBS News Video, MedicalNewsToday Article
2. Establishing a large, multi-centre brain imaging database, in conjunction with the Biomedical Imaging Analysis Group at Imperial College, for the purpose of predicting stroke outcome. See: NatureWorldNews Article.
3. World-first trial of selected CD34+ stem cells in stoke, whilst developing imaging techniques that can monitor cell-homing and revascularization. See: Telegraph Article
Bentley P, Driver J, Dolan RJ, 2008, Cholinesterase inhibition modulates visual and attentional brain responses in Alzheimer's disease and health, Brain, Vol:131, ISSN:0006-8950, Pages:409-424
Bentley P, Driver J, Dolan RJ, 2009, Modulation of fusiform cortex activity by cholinesterase inhibition predicts effects on subsequent memory, Brain, Vol:132, ISSN:0006-8950, Pages:2356-2371
et al., 2010, Causal Relationship of Susceptibility Genes to Ischemic Stroke: Comparison to Ischemic Heart Disease and Biochemical Determinants, PLOS One, Vol:5, ISSN:1932-6203
et al., 2011, CADASIL with cord involvement associated with a novel and atypical NOTCH3 mutation, Journal of Neurology Neurosurgery and Psychiatry, Vol:82, ISSN:0022-3050, Pages:855-860
McColgan P, Sharma P, Bentley P, 2011, Stem Cell Tracking in Human Trials: A Meta-Regression, Stem Cell Reviews, Vol:7, ISSN:1550-8943, Pages:1031-1040
Bentley P, Driver J, Dolan RJ, 2011, Cholinergic modulation of cognition: Insights from human pharmacological functional neuroimaging, Progress in Neurobiology, Vol:94, ISSN:0301-0082, Pages:360-388
et al., 2013, Triple dissociation of attention networks in stroke according to lesion location, Neurology, Vol:81, ISSN:0028-3878, Pages:812-820