Imperial College London

DrPaulBentley

Faculty of MedicineDepartment of Medicine

Senior Clinical Research Fellow
 
 
 
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p.bentley

 
 
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10L21Charing Cross HospitalCharing Cross Campus

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Summary

 

Publications

Publication Type
Year
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69 results found

Chen L, Bentley P, Mori K, Misawa K, Fujiwara M, Rueckert Det al., 2018, DRINet for Medical Image Segmentation, IEEE TRANSACTIONS ON MEDICAL IMAGING, Vol: 37, Pages: 2453-2462, ISSN: 0278-0062

JOURNAL ARTICLE

Li K, Bentley P, Nair A, Halse O, Barker G, Russell C, Soto D, Malhotra PAet al., 2018, Reward sensitivity predicts dopaminergic response in spatial neglect., Cortex

It has recently been revealed that spatial neglect can be modulated by motivational factors including anticipated monetary reward. A number of dopaminergic agents have been evaluated as treatments for neglect, but the results have been mixed, with no clear anatomical or cognitive predictors of dopaminergic responsiveness. Given that the effects of incentive motivation are mediated by dopaminergic pathways that are variably damaged in stroke, we tested the hypothesis that the modulatory influences of reward and dopaminergic drugs on neglect are themselves related. We employed a single-dose, double-blind, crossover design to compare the effects of Co-careldopa and placebo on a modified visual cancellation task in patients with neglect secondary to right hemisphere stroke. Whilst confirming that reward improved visual search in this group, we showed that dopaminergic stimulation only enhances visual search in the absence of reward. When patients were divided into REWARD-RESPONDERs and REWARD-NON-RESPONDERs, we found an interaction, such that only REWARD-NON-RESPONDERs showed a positive response to reward after receiving Co-careldopa, whereas REWARD-RESPONDERs were not influenced by drug. At a neuroanatomical level, responsiveness to incentive motivation was most associated with intact dorsal striatum. These findings suggest that dopaminergic modulation of neglect follows an 'inverted U' function, is dependent on integrity of the reward system, and can be measured as a behavioural response to anticipated reward.

JOURNAL ARTICLE

Chen L, Jones ALC, Mair G, Patel R, Gontsarova A, Ganesalingam J, Math N, Dawson A, Aweid B, Cohen D, Mehta A, Wardlaw J, Rueckert D, Bentley Pet al., 2018, Rapid Automated Quantification of Cerebral Leukoaraiosis on CT Images: A Multicenter Validation Study, RADIOLOGY, Vol: 288, Pages: 573-581, ISSN: 0033-8419

JOURNAL ARTICLE

Bentley P, Sharma P, 2018, Neurological disorders - epilepsy, Parkinson's disease and multiple sclerosis, Clinical pharmacology: 12th edition, Editors: Brown, Sharma, Mir, Bennett, Publisher: Elsevier, ISBN: 978-0702073281

BOOK CHAPTER

Rinne P, Hassan M, Fernandes C, Han E, Hennessy E, Waldman A, Sharma P, Soto D, Leech R, Malhotra PA, Bentley Pet al., 2018, Motor dexterity and strength depend upon integrity of the attention-control system, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 115, Pages: E536-E545, ISSN: 0027-8424

JOURNAL ARTICLE

Bentley P, Burdet E, Rinne P, Mace M, Liardon J-Let al., 2018, A force measurement mechanism, 15544596

PATENT

Mace M, Kinany N, Rinne P, Rayner A, Bentley P, Burdet Eet al., 2017, Balancing the playing field: collaborative gaming for physical training, JOURNAL OF NEUROENGINEERING AND REHABILITATION, Vol: 14, ISSN: 1743-0003

JOURNAL ARTICLE

Mace M, Rinne P, Liardon J-L, Uhomoibhi C, Bentley P, Burdet Eet al., 2017, Elasticity improves handgrip performance and user experience during visuomotor control, ROYAL SOCIETY OPEN SCIENCE, Vol: 4, ISSN: 2054-5703

JOURNAL ARTICLE

Mace M, Rinne P, Kinany N, Bentley P, Burdet Eet al., 2017, Collaborative Gaming to Enhance Patient Performance During Virtual Therapy, 3rd International Conference on NeuroRehabilitation (ICNR), Publisher: SPRINGER INTERNATIONAL PUBLISHING AG, Pages: 375-379, ISSN: 2195-3562

CONFERENCE PAPER

Chen L, Bentley P, Rueckert D, 2017, Fully automatic acute ischemic lesion segmentation in DWI using convolutional neural networks, NEUROIMAGE-CLINICAL, Vol: 15, Pages: 633-643, ISSN: 2213-1582

JOURNAL ARTICLE

Maier O, Menze BH, von der Gablentz J, Hani L, Heinrich MP, Liebrand M, Winzeck S, Basit A, Bentley P, Chen L, Christiaens D, Dutil F, Egger K, Feng C, Glocker B, Goetz M, Haeck T, Halme H-L, Havaei M, Iftekharuddin KM, Jodoin P-M, Kamnitsas K, Kellner E, Korvenoja A, Larochelle H, Ledig C, Lee J-H, Maes F, Mahmood Q, Maier-Hein KH, McKinley R, Muschelli J, Pal C, Pei L, Rangarajan JR, Reza SMS, Robben D, Rueckert D, Salli E, Suetens P, Wang C-W, Wilms M, Kirschke JS, Kraemer UM, Muente TF, Schramme P, Wiest R, Handels H, Reyes Met al., 2017, ISLES 2015-A public evaluation benchmark for ischemic stroke lesion segmentation from multispectral MRI, MEDICAL IMAGE ANALYSIS, Vol: 35, Pages: 250-269, ISSN: 1361-8415

JOURNAL ARTICLE

Rinne P, Mace M, Nakornchai T, Zimmerman K, Fayer S, Sharma P, Liardon J-L, Burdet E, Bentley Pet al., 2016, Democratizing Neurorehabilitation: How Accessible are Low-Cost Mobile-Gaming Technologies for Self-Rehabilitation of Arm Disability in Stroke?, PLOS ONE, Vol: 11, ISSN: 1932-6203

JOURNAL ARTICLE

Tran T, Cotlarciuc I, Yadav S, Hasan N, Bentley P, Levi C, Worrall BB, Meschia JF, Rost N, Sharma Pet al., 2016, Candidate-gene analysis of white matter hyperintensities on neuroimaging., J Neurol Neurosurg Psychiatry, Vol: 87, Pages: 260-266

BACKGROUND: White matter hyperintensities (WMH) are a common radiographic finding and may be a useful endophenotype for small vessel diseases. Given high heritability of WMH, we hypothesised that certain genotypes may predispose individuals to these lesions and consequently, to an increased risk of stroke, dementia and death. We performed a meta-analysis of studies investigating candidate genes and WMH to elucidate the genetic susceptibility to WMH and tested associated variants in a new independent WMH cohort. We assessed a causal relationship of WMH to methylene tetrahydrofolate reductase (MTHFR). METHODS: Database searches through March 2014 were undertaken and studies investigating candidate genes in WMH were assessed. Associated variants were tested in a new independent ischaemic cohort of 1202 WMH patients. Mendelian randomization was undertaken to assess a causal relationship between WMH and MTHFR. RESULTS: We identified 43 case-control studies interrogating eight polymorphisms in seven genes covering 6,314 WMH cases and 15,461 controls. Fixed-effects meta-analysis found that the C-allele containing genotypes of the aldosterone synthase CYP11B2 T(-344)C gene polymorphism were associated with a decreased risk of WMH (OR=0.61; 95% CI, 0.44 to 0.84; p=0.003). Using mendelian randomisation the association among MTHFR C677T, homocysteine levels and WMH, approached, but did not reach, significance (expected OR=1.75; 95% CI, 0.90-3.41; observed OR=1.68; 95% CI, 0.97-2.94). Neither CYP11B2 T(-344)C nor MTHFR C677T were significantly associated when tested in a new independent cohort of 1202 patients with WMH. CONCLUSIONS: There is a genetic basis to WMH but anonymous genome wide and exome studies are more likely to provide novel loci of interest.

JOURNAL ARTICLE

Gunnoo T, Hasan N, Khan MS, Slark J, Bentley P, Sharma Pet al., 2016, Quantifying the risk of heart disease following acute ischaemic stroke: a meta-analysis of over 50,000 participants., BMJ Open, Vol: 6

OBJECTIVE: Following an acute stroke, there is a high risk of recurrence. However, the leading cause of mortality following a stroke is due to coronary artery disease (CAD) and myocardial infarction (MI) but that risk has not been robustly quantified. We sought to reliably quantify the risk of ischaemic heart disease (IHD) in patients presenting with acute ischaemic stroke (AIS) in the absence of a known cardiac history. SETTING: A meta-analysis study. PubMed, MEDLINE, EMBASE and Google Scholar were searched for potential studies up to October 2015. Included studies reported an acute cerebral ischaemic event and followed for CAD or MI within 1 year in patients without known IHD. Using arcsine transformed proportions for meta-analysis, studies were combined using a generic inverse variance random-effects model to calculate the pooled standardised mean difference and 95% CIs. These were interpreted as the percentage prevalence of CAD or incidence of MI following AIS. RESULTS: 17 studies with 4869 patients with AIS demonstrated a mean average of asymptomatic CAD in 52%. Anatomical methods of CAD detection revealed a prevalence of asymptomatic ≥ 50% coronary stenosis in 32% (95% CI 19% to 47%; p<0.00001). 8 studies with 47229 patients with ischaemic stroke revealed an overall risk of MI in the year following stroke of 3% (95% CI 1% to 5%; p<0.00001) despite the absence of any cardiac history. CONCLUSIONS: One-third of patients with ischaemic stroke with no cardiac history have more than 50% coronary stenosis and 3% are at risk of developing MI within a year. Our findings provide a reliable quantitative measure of the risk of IHD following AIS in patients with no cardiac history.

JOURNAL ARTICLE

Barrow T, Khan MS, Halse O, Bentley P, Sharma Pet al., 2016, Estimating Weight of Patients With Acute Stroke When Dosing for Thrombolysis., Stroke, Vol: 47, Pages: 228-231

BACKGROUND AND PURPOSE: Estimating patient weight forms an important part of emergency ischemic stroke management guiding the dose of alteplase (tissue-type plasminogen activator). Weighing patients with stroke can be logistically challenging and time consuming, potentially delaying treatment times. We aimed to assess the reliability of approximating weight to determine recombinant tissue-type plasminogen activator dose and whether potential inaccurate dosing affected patient outcomes. METHODS: Two hundred forty-two consecutive patients were studied at a large tertiary stroke center. Estimated and actual measured weight, alteplase dose, and pre-and post-modified Rankin Scale/National Institute of Health Stroke Scale outcome were recorded for each patient. RESULTS: Clinicians significantly underestimated weights by 1.13 kg (range, -43 to +18 kg; SD, 7.14; P<0.05). The difference between estimated and actual weight proved to be greatest in the heaviest third of patients (-4.51 kg; SD, 8.35; P<0.001), resulting in 19.7% of patients receiving a deviation of at least 10% from the recommended recombinant tissue-type plasminogen activator dose. On average, the heaviest third of patients received an underdose of 0.04 mg/kg and were found to have a greater baseline National Institute of Health Stroke Scale on admission (P<0.001). National Institute of Health Stroke Scale improvement by day 7 or on discharge was significantly reduced in patients weighing >78 kg (National Institute of Health Stroke Scale score difference of 4.0 points, P<0.05) than in lighter individuals. CONCLUSIONS: Clinicians are poor at approximating the weights of patients with stroke in the acute setting, especially when patients lie at the extremes of weight. Beds capable of weighing patients should be mandated in emergency rooms for patients with acute stroke.

JOURNAL ARTICLE

Rinne P, Hassan M, Liardon J, Mace M, Burdet E, Bentley Pet al., 2015, Hand-and-brain training after motor stroke: Defining the problem and innovating a solution, INTERNATIONAL JOURNAL OF STROKE, Vol: 10, Pages: 67-67, ISSN: 1747-4930

JOURNAL ARTICLE

Mace M, Rinne P, Liardon J, Bentley P, Burdet Eet al., Comparison of flexible and rigid hand-grip control during a feed-forward visual tracking task, Rehabilitation Robotics (ICORR), 2015 IEEE International Conference on, ISSN: 1945-7901

CONFERENCE PAPER

Lobotesis K, Mahady K, Ganesalingam J, Amlani S, Carlton-Jones L, Davies NWS, Bentley Pet al., 2015, Coiling-associated delayed cerebral hypersensitivity: Is nickel the link?, Neurology, Vol: 84, Pages: 97-99

JOURNAL ARTICLE

Chen L, Tong T, Ho CP, Patel R, Cohen D, Dawson AC, Halse O, Geraghty O, Rinne PEM, White CJ, Nakornchai T, Bentley P, Rueckert Det al., 2015, Identification of Cerebral Small Vessel Disease Using Multiple Instance Learning, MEDICAL IMAGE COMPUTING AND COMPUTER-ASSISTED INTERVENTION - MICCAI 2015, PT I, Vol: 9349, Pages: 523-530, ISSN: 0302-9743

JOURNAL ARTICLE

Majersik JJ, Cole JW, Golledge J, Rost NS, Chan Y-FY, Gurol ME, Lindgren AG, Woo D, Fernandez-Cadenas I, Chen DT, Thijs V, Worrall BB, Kamal A, Bentley P, Wardlaw JM, Ruigrok YM, Battey TWK, Schmidt R, Montaner J, Giese A-K, Roquer J, Jimenez-Conde J, Lee C, Ay H, Jose Martin J, Rosand J, Maguire Jet al., 2015, Recommendations From the International Stroke Genetics Consortium, Part 1 Standardized Phenotypic Data Collection, STROKE, Vol: 46, Pages: 279-+, ISSN: 0039-2499

JOURNAL ARTICLE

Mace M, Rinne P, Liardon J-L, Bentley P, Burdet Eet al., 2015, Comparison of flexible and rigid hand-grip control during a feed-forward visual tracking task, 14th IEEE/RAS-EMBS International Conference on Rehabilitation Robotics (ICORR), Publisher: IEEE, Pages: 792-797, ISSN: 1945-7898

CONFERENCE PAPER

Banerjee S, Bentley P, Hamady M, Marley S, Davis J, Shlebak A, Nicholls J, Williamson DA, Jensen SL, Gordon M, Habib N, Chataway Jet al., 2014, Intra-Arterial Immunoselected CD34+Stem Cells for Acute Ischemic Stroke, STEM CELLS TRANSLATIONAL MEDICINE, Vol: 3, Pages: 1322-1330, ISSN: 2157-6564

JOURNAL ARTICLE

Epton S, Bentley P, Ganesalingam J, Dias A, Mahady K, Rinne P, Sharma P, Halse O, Mehta A, Rueckert Det al., 2014, CTBRAIN MACHINE LEARNING PREDICTS STROKE THROMBOLYSIS RESULT, Meeting of the Associatiion-of-British-Neurologists, Publisher: BMJ PUBLISHING GROUP, ISSN: 0022-3050

CONFERENCE PAPER

Bentley P, Kumar G, Rinne P, Buddha S, Kallingal J, Hookway C, Sharma P, Mehta A, Beckmann Cet al., 2014, Lesion locations influencing baseline severity and early recovery in ischaemic stroke, EUROPEAN JOURNAL OF NEUROLOGY, Vol: 21, Pages: 1226-1232, ISSN: 1351-5101

JOURNAL ARTICLE

Slark J, Khan MS, Bentley P, Sharma Pet al., 2014, Knowledge of blood pressure in a UK general public population, JOURNAL OF HUMAN HYPERTENSION, Vol: 28, Pages: 500-503, ISSN: 0950-9240

JOURNAL ARTICLE

de Bourbon-Teles J, Bentley P, Koshino S, Shah K, Dutta A, Malhotra P, Egner T, Husain M, Soto Det al., 2014, Thalamic Control of Human Attention Driven by Memory and Learning, CURRENT BIOLOGY, Vol: 24, Pages: 993-999, ISSN: 0960-9822

JOURNAL ARTICLE

Devine MJ, Bentley P, Jones B, Hotton G, Greenwood RJ, Jenkins IH, Joyce EM, Malhotra PAet al., 2014, The role of the right inferior frontal gyrus in the pathogenesis of post-stroke psychosis, JOURNAL OF NEUROLOGY, Vol: 261, Pages: 600-603, ISSN: 0340-5354

JOURNAL ARTICLE

Rinne PE, Soto D, Sharma P, Leech R, Bentley Pet al., 2014, Post-exercise brain network connectivity modulations in motor stroke, CEREBROVASCULAR DISEASES, Vol: 37, Pages: 46-46, ISSN: 1015-9770

JOURNAL ARTICLE

Bentley P, Ganesalingam J, Jones ALC, Mahady K, Epton S, Rinne P, Sharma P, Halse O, Mehta A, Rueckert Det al., 2014, Prediction of stroke thrombolysis outcome using CT brain machine learning, NEUROIMAGE-CLINICAL, Vol: 4, Pages: 635-640, ISSN: 2213-1582

JOURNAL ARTICLE

Slark J, Khan MS, Bentley P, Sharma Pet al., 2014, Individual Risk Awareness Intervention in Stroke (IRAIS): A Randomized Controlled Trial., J Neurol Disord Stroke, Vol: 1035

JOURNAL ARTICLE

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