Imperial College London
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DrPaulBentley

Faculty of Medicine, Department of Brain Sciences

Senior Clinical Research Fellow
 
 
 
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Contact

 

p.bentley

 
 
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Location

 

10L21Charing Cross HospitalCharing Cross Campus

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Summary

 

Publications

Citation

BibTex format

@article{Rinne:2018:10.1073/pnas.1715617115,
author = {Rinne, P and Hassan, M and Fernandes, C and Han, E and Hennessy, E and Waldman, A and Sharma, P and Soto, D and Leech, R and Malhotra, P and Bentley, P},
doi = {10.1073/pnas.1715617115},
journal = {Proceedings of the National Academy of Sciences},
pages = {E536--E545},
title = {Motor dexterity and strength depend upon integrity of the attention-control system},
url = {http://dx.doi.org/10.1073/pnas.1715617115},
volume = {115},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Attention control (or executive control) is a higher cognitive function involved in response selection and inhibition, through close interactions with the motor system. Here, we tested whether influences of attention control are also seen on lower level motor functions of dexterity and strength—by examining relationships between attention control and motor performance in healthy-aged and hemiparetic-stroke subjects (n = 93 and 167, respectively). Subjects undertook simple-tracking, precision-hold, and maximum force-generation tasks, with each hand. Performance across all tasks correlated strongly with attention control (measured as distractor resistance), independently of factors such as baseline performance, hand use, lesion size, mood, fatigue, or whether distraction was tested during motor or nonmotor cognitive tasks. Critically, asymmetric dissociations occurred in all tasks, in that severe motor impairment coexisted with normal (or impaired) attention control whereas normal motor performance was never associated with impaired attention control (below a task-dependent threshold). This implies that dexterity and force generation require intact attention control. Subsequently, we examined how motor and attention-control performance mapped to lesion location and cerebral functional connectivity. One component of motor performance (common to both arms), as well as attention control, correlated with the anatomical and functional integrity of a cingulo-opercular “salience” network. Independently of this, motor performance difference between arms correlated negatively with the integrity of the primary sensorimotor network and corticospinal tract. These results suggest that the salience network, and its attention-control function, are necessary for virtually all volitional motor acts while its damage contributes significantly to the cardinal motor deficits of stroke.
AU  - Rinne,P
AU  - Hassan,M
AU  - Fernandes,C
AU  - Han,E
AU  - Hennessy,E
AU  - Waldman,A
AU  - Sharma,P
AU  - Soto,D
AU  - Leech,R
AU  - Malhotra,P
AU  - Bentley,P
DO  - 10.1073/pnas.1715617115
EP  - 545
PY  - 2018///
SN  - 0027-8424
SP  - 536
TI  - Motor dexterity and strength depend upon integrity of the attention-control system
T2  - Proceedings of the National Academy of Sciences
UR  - http://dx.doi.org/10.1073/pnas.1715617115
UR  - http://hdl.handle.net/10044/1/55777
VL  - 115
ER  -
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