Imperial College London

Professor Patrice D. Cani

Faculty of MedicineDepartment of Surgery & Cancer

Visiting Professor
 
 
 
//

Contact

 

p.cani Website CV

 
 
//

Location

 

Sir Alexander Fleming BuildingSouth Kensington Campus

//

Summary

 

Summary

Research Interests

Prof. Cani's main research interests are the investigation of integrative physiology in complex biological systems and its relationship with gut microbes. By combining different "omics" approaches such as metabonomics, metagenomics, lipidomics, and transcriptomics, he found that the endocannabinoid system, the innate immune system and gut bacteria are playing a role in the onset of obesity, type 2 diabetes, cardiometabolic disorders and metabolic inflammation. His motto is "In Gut we Trust"

Short biography

Professor at the Université catholique de Louvain, Brussels, Belgium, Patrice D. Cani is researcher from the Belgian Fund for Scientific Research and group leader in the Metabolism and Nutrition lab at the Louvain Drug Research Institute from the UCL, Brussels, Belgium.

He is Visiting Professor at the Imperial College London since 2010 at the Faculty of Medicine, Section of Biomolecular Medicine, Department of Surgery and Cancer

He is recipient of the prestigious Inbev-Baillet Latour grant for medical research (2015), the international Prize of Physiology Lucien Dautrebande (2016).

Prof. Cani is co-director (with Prof. C. Knauf) of the European Associated Laboratory : “NeuroMicrobiota” (INSERM, Toulouse, France/UCL, Brussels, Belgium).

He is Dietitian and holds two masters, one in M.Sc. in Human Nutrition and another M.Sc. in Health Sciences, and he holds a PhD in Biomedical Sciences.

He is WELBIO investigator and recipient of an European Research Council (ERC) Starting Grant 2013 (ENIGMO) and PoC ERC 2016 (Microbes4U).

He is author and co-author of more than 180 scientific research publications, reviews and book chapters.

Selected publications:

 

 

Duparc T, Plovier H, Marrachelli VG, Van Hul M, Essaghir A, Ståhlman M, Matamoros S, Geurts L, Pardo-Tendero MM, Druart C, Delzenne NM, Demoulin JB, van der Merwe SW, van Pelt J, Bäckhed F, Monleon D, Everard A, Cani PD.

 Hepatocyte MyD88 affects bile acids, gut microbiota and metabolome contributing to regulate glucose and lipid metabolism.

Gut. 2016 May 5. pii: gutjnl-2015-310904. doi: 10.1136/gutjnl-2015-310904. [Epub ahead of print]

 

Cani PD, Plovier H, Van Hul M, Geurts L, Delzenne NM, Druart C, Everard A.

 Endocannabinoids - at the crossroads between the gut microbiota and host metabolism.

Nat Rev Endocrinol. 2016 Mar;12(3):133-43.

 

Everard A, Geurts L, Caesar R, Van Hul M, Matamoros M, Duparc T, Denis RGP, Cochez P, Pierard P, Castel J, Bindels LB, Plovier H , Robine R, Muccioli GG, Renauld JC, Dumoutier L, Delzenne NM, Luquet S, Bäckhed F, Cani PD

Intestinal epithelial MyD88 is a sensor switching host metabolism towards obesity according to nutritional status

Nature Communications, I.F.: 11.47, 2014, 5;5:5648

 

Geurts L, Everard A*, Van Hul M*, Essaghir A, Duparc T, Matamoros S, Plovier H, Castel J, Denis RGP, Bergiers M, Druart C, Alhouayek M, Delzenne NM, Muccioli GG, Demoulin JB, Luquet S, Cani PD.

Adipose tissue NAPE-PLD controls fat mass development by altering the browning process and gut microbiota

Nature Communications, I.F.: 11.47, 2015, 6:6495

 

Everard A, Lazarevic V, Gaïa N, Johansson M, Ståhlman M, Bäckhed F, Delzenne NM, Schrenzel J, François P, Cani PD. Microbiome of prebiotic-treated mice reveals novel targets involved in host response during obesity.

 ISME J., 2014 Apr 3. doi: 10.1038/ismej.2014.45.

 

Cani PD. Metabolism in 2013: The gut microbiota manages host metabolism.

 Nat Rev Endocrinol., 2014, 10:74-6

 

Everard A, Belzer C, Geurts L, Ouwerkerk JP, Druart C, Bindels LB, Guiot Y, Derrien M, Muccioli GG, Delzenne NM, de Vos WM, Cani PD. Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity.

 Proc Natl Acad Sci U S A, 2013, 110, 9066-71

 

Wichmann A, Allahyar A, Greiner TU, Plovier H, Lundén GÖ, Larsson T, Drucker DJ, Delzenne NM, Cani PD, Bäckhed F. Microbial modulation of energy availability in the colon regulates intestinal transit.

 Cell Host Microbe. , 2013, 14:582-90.

 

Alhouayek M, Masquelier J, Cani PD, Lambert DM, Muccioli GG. Implication of the anti-inflammatory bioactive lipid prostaglandin D2-glycerol ester in the control of macrophage activation and inflammation by ABHD6.

 Proc Natl Acad Sci U S A, 2013 110, 17558-63.

 

Everard A, Lazarevic, Derrien M, Girard M, Muccioli GG, Neyrinck AM, Possemiers S, Van Holle A, François P, de Vos WM, Delzenne NM, Schrenzel J, Cani PD. Responses of gut microbiota, glucose and lipid metabolism to prebiotics in genetic obese and diet-induced leptin-resistant mice.

 Diabetes, 2011, 60, 2775-86

 

Muccioli GG, Naslain D, Backhed F, Reigstad CS, Lambert DM, Delzenne NM, Cani PD. The endocannabinoid system links gut microbiota to adipogenesis.

 Mol Syst Biol, 2010, 6, 392

 

Teperino R, Amann S, Bayer M, McGee SL, Loipetzberger A, Connor T, Jaeger C, Kammerer B, Winter L, Wiche G, Dalgaard K, Selvaraj M, Gaster M, Lee-Young RS, Febbraio MA, Knauf C, Cani PD, Aberger F, Penninger JM, Pospisilik JA, Esterbauer H. Hedgehog Partial Agonism Drives Warburg-like Metabolism in Muscle and Brown Fat.

 Cell, 2012, 151, 414-26

 

Membership of Societes

  • Funding member of the BNS (Belgian Nutrition Society) in 2008
  • Fellow of the New York Academy of Sciences (NYAS)
  • Fellow of the SFD (Société Francophone du Diabète)
  • Alumni from the ENLP (European Nutrition Leadership Platform) in 2008, programme accessible upon strict selection and providing European certification
  • Fellow of the ADA (American Diabetes Association)
  • Invited member and Alumni of the Belgian Royal Academy of Sciences (Académie Royale de Belgique, Collège des Alumni, Classe des Sciences)

 

 

 

 

 

    Publications

    Journals

    Brooks L, Viardot A, Tsakmaki A, et al., 2017, Fermentable carbohydrate stimulates FFAR2-dependent colonic PYY cell expansion to increase satiety, Molecular Metabolism, Vol:6, ISSN:2212-8778, Pages:48-60

    Plovier H, Everard A, Druart C, et al., 2017, A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice, Nature Medicine, Vol:23, ISSN:1078-8956, Pages:107-113

    Tilg H, Cani PD, Mayer EA, 2016, Gut microbiome and liver diseases., Gut, Vol:65, Pages:2035-2044

    Dao MC, Everard A, Aron-Wisnewsky J, et al., 2016, Akkermansia muciniphila and improved metabolic health during a dietary intervention in obesity: relationship with gut microbiome richness and ecology, Gut, Vol:65, ISSN:0017-5749, Pages:426-436

    More Publications