The brain is composed of billions of neurons that are intricately connected within small circuits. We are interested in the roles that these circuits play in sensory perception and behaviour. To do this, we record the electrical activity of single cells and small populations, combining advanced electrophysiology and molecular tools to record and manipulate neuronal activity in behaving animals.
We are especially interested in how the circuits of neocortex and cerebellum combine information from the outside world (the senses) with internally generated signals (thoughts and intentions) to appropriately guide behaviour. Our goal is to understand how computation by neural circuits is applied in the representation of the external and internal world.
Our research publications can be found at the tab above, or on Google Scholar
et al., 2018, ON-OFF receptive fields in auditory cortex diverge during development and contribute to directional sweep selectivity, Nature Communications, Vol:9, ISSN:2041-1723
et al., 2017, Robotic automation of in vivo two photon targeted whole-cell patch clamp electrophysiology, Neuron, Vol:95, ISSN:0896-6273, Pages:1048-1055.e3
Chen S, Augustine GJ, Chadderton P, 2017, Serial processing of kinematic signals by cerebellar circuitry during voluntary whisking., Nat Commun, Vol:8
Chen S, Augustine GJ, Chadderton PT, 2016, The cerebellum linearly encodes whisker position during voluntary movement, Elife, Vol:5, ISSN:2050-084X
et al., 2014, Sensory-evoked synaptic integration in cerebellar and cerebral cortical neurons, Nature Reviews Neuroscience, Vol:15, ISSN:1471-003X, Pages:71-83
et al., 2009, The Synaptic Representation of Sound Source Location in Auditory Cortex, Journal of Neuroscience, Vol:29, ISSN:0270-6474, Pages:14127-14135
et al., 2007, High-fidelity transmission of sensory information by single cerebellar mossy fibre boutons, Nature, Vol:450, ISSN:0028-0836, Pages:1245-U12