Imperial College London

DrPaulChadderton

Faculty of EngineeringDepartment of Bioengineering

Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 0770p.chadderton Website

 
 
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Location

 

3.14Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
to

15 results found

Annecchino LA, Morris AR, Copeland CS, Agabi OE, Chadderton P, Schultz SRet al., 2017, Robotic Automation of In Vivo Two-Photon Targeted Whole-Cell Patch-Clamp Electrophysiology, NEURON, Vol: 95, Pages: 1048-+, ISSN: 0896-6273

JOURNAL ARTICLE

Chen S, Augustine GJ, Chadderton P, 2017, Serial processing of kinematic signals by cerebellar circuitry during voluntary whisking., Nat Commun, Vol: 8

Purkinje cells (PCs) in Crus 1 represent whisker movement via linear changes in firing rate, but the circuit mechanisms underlying this coding scheme are unknown. Here we examine the role of upstream inputs to PCs-excitatory granule cells (GCs) and inhibitory molecular layer interneurons-in processing of whisking signals. Patch clamp recordings in GCs reveal that movement is accompanied by changes in mossy fibre input rate that drive membrane potential depolarisation and high-frequency bursting activity at preferred whisker angles. Although individual GCs are narrowly tuned, GC populations provide linear excitatory drive across a wide range of movement. Molecular layer interneurons exhibit bidirectional firing rate changes during whisking, similar to PCs. Together, GC populations provide downstream PCs with linear representations of volitional movement, while inhibitory networks invert these signals. The exquisite sensitivity of neurons at each processing stage enables faithful propagation of kinematic representations through the cerebellum.Cerebellar Purkinje cells (PCs) linearly encode whisker position but the precise circuit mechanisms that generate these signals are not well understood. Here the authors use patch clamp recordings to show that selective tuning of granule cell inputs and bidirectional tuning of interneuron inputs are required to generate the kinematic representations in PCs.

JOURNAL ARTICLE

Chen S, Augustine GJ, Chadderton P, 2016, The cerebellum linearly encodes whisker position during voluntary movement, ELIFE, Vol: 5, ISSN: 2050-084X

JOURNAL ARTICLE

Sollini J, Chadderton P, 2016, Comodulation Enhances Signal Detection via Priming of Auditory Cortical Circuits, JOURNAL OF NEUROSCIENCE, Vol: 36, Pages: 12299-12311, ISSN: 0270-6474

JOURNAL ARTICLE

Duguid I, Branco T, Chadderton P, Arlt C, Powell K, Haeusser Met al., 2015, Control of cerebellar granule cell output by sensory-evoked Golgi cell inhibition, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 112, Pages: 13099-13104, ISSN: 0027-8424

JOURNAL ARTICLE

Chadderton P, Schaefer AT, Williams SR, Margrie TWet al., 2014, Sensory-evoked synaptic integration in cerebellar and cerebral cortical neurons, NATURE REVIEWS NEUROSCIENCE, Vol: 15, Pages: 71-83, ISSN: 1471-003X

JOURNAL ARTICLE

Duguid I, Branco T, London M, Chadderton P, Haeusser Met al., 2012, Tonic Inhibition Enhances Fidelity of Sensory Information Transmission in the Cerebellar Cortex, JOURNAL OF NEUROSCIENCE, Vol: 32, Pages: 11132-11143, ISSN: 0270-6474

JOURNAL ARTICLE

Harris KD, Bartho P, Chadderton P, Curto C, de la Rocha J, Hollender L, Itskov V, Luczak A, Marguet SL, Renart A, Sakata Set al., 2011, How do neurons work together? Lessons from auditory cortex, HEARING RESEARCH, Vol: 271, Pages: 37-53, ISSN: 0378-5955

JOURNAL ARTICLE

Saleem AB, Chadderton P, Apergis-Schoute J, Harris KD, Schultz SRet al., 2010, Methods for predicting cortical UP and DOWN states from the phase of deep layer local field potentials, JOURNAL OF COMPUTATIONAL NEUROSCIENCE, Vol: 29, Pages: 49-62, ISSN: 0929-5313

JOURNAL ARTICLE

Chadderton P, Agapiou JP, McAlpine D, Margrie TWet al., 2009, The Synaptic Representation of Sound Source Location in Auditory Cortex, JOURNAL OF NEUROSCIENCE, Vol: 29, Pages: 14127-14135, ISSN: 0270-6474

JOURNAL ARTICLE

Rancz EA, Ishikawa T, Duguid I, Chadderton P, Mahon S, Haeusser Met al., 2007, High-fidelity transmission of sensory information by single cerebellar mossy fibre boutons, NATURE, Vol: 450, Pages: 1245-U12, ISSN: 0028-0836

JOURNAL ARTICLE

Loewenstein Y, Mahon S, Chadderton P, Kitamura K, Sompolinsky H, Yarom Y, Hausser MHet al., 2006, Purkinje cells in awake behaving animals operate at the upstate membrane potential - Reply, NATURE NEUROSCIENCE, Vol: 9, Pages: 461-461, ISSN: 1097-6256

JOURNAL ARTICLE

Loewenstein Y, Mahon S, Chadderton P, Kitamura K, Sompolinsky H, Yarom Y, Hausser MHet al., 2005, Bistability of cerebellar Purkinje cells modulated by sensory stimulation, NATURE NEUROSCIENCE, Vol: 8, Pages: 202-211, ISSN: 1097-6256

JOURNAL ARTICLE

Chadderton P, Margrie TW, Hausser M, 2004, Integration of quanta in cerebellar granule cells during sensory processing, NATURE, Vol: 428, Pages: 856-860, ISSN: 0028-0836

JOURNAL ARTICLE

Mittmann W, Chadderton P, Hausser M, 2004, Neuronal microcircuits: Frequency-dependent flow of inhibition, CURRENT BIOLOGY, Vol: 14, Pages: R837-R839, ISSN: 0960-9822

JOURNAL ARTICLE

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