Imperial College London
Portrait Picture

ProfessorPeterLee

Faculty of Engineering, Department of Materials

Visiting Professor
 
 
 
//

Contact

 

+44 (0)20 7594 6801p.d.lee

 
 
//

Location

 

102Royal School of MinesSouth Kensington Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Javaheri:2020:10.1126/sciadv.aax8301,
author = {Javaheri, B and Razi, H and Gohin, S and Wylie, S and Chang, Y-M and Salmon, P and Lee, PD and Pitsillides, AA},
doi = {10.1126/sciadv.aax8301},
journal = {Science Advances},
pages = {1--13},
title = {Lasting organ-level bone mechanoadaptation is unrelated to local strain},
url = {http://dx.doi.org/10.1126/sciadv.aax8301},
volume = {6},
year = {2020}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Bones adapt to mechanical forces according to strict principles predicting straight shape. Most bones are, however, paradoxically curved. To solve this paradox, we used computed tomography–based, four-dimensional imaging methods and computational analysis to monitor acute and chronic whole-bone shape adaptation and remodeling in vivo. We first confirmed that some acute load-induced structural changes are reversible, adhere to the linear strain magnitude regulation of remodeling activities, and are restricted to bone regions in which marked antiresorptive actions are evident. We make the novel observation that loading exerts significant lasting modifications in tibial shape and mass across extensive bone regions, underpinned by (re)modeling independent of local strain magnitude, occurring at sites where the initial response to load is principally osteogenic. This is the first report to demonstrate that bone loading stimulates nonlinear remodeling responses to strain that culminate in greater curvature adjusted for load predictability without sacrificing strength.
AU  - Javaheri,B
AU  - Razi,H
AU  - Gohin,S
AU  - Wylie,S
AU  - Chang,Y-M
AU  - Salmon,P
AU  - Lee,PD
AU  - Pitsillides,AA
DO  - 10.1126/sciadv.aax8301
EP  - 13
PY  - 2020///
SN  - 2375-2548
SP  - 1
TI  - Lasting organ-level bone mechanoadaptation is unrelated to local strain
T2  - Science Advances
UR  - http://dx.doi.org/10.1126/sciadv.aax8301
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000519001400012&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://advances.sciencemag.org/content/6/10/eaax8301
UR  - http://hdl.handle.net/10044/1/78905
VL  - 6
ER  -
Download