Imperial College London


Faculty of Natural SciencesDepartment of Mathematics

Chair in Applied Mathematics



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BibTex format

author = {Peurichard, D and Ousset, M and Paupert, J and Aymard, B and Lorsignol, A and Casteilla, L and Degond, P},
doi = {10.1016/j.jtbi.2019.02.017},
journal = {Journal of Theoretical Biology},
pages = {127--136},
title = {Extra-cellular matrix rigidity may dictate the fate of injury outcome},
url = {},
volume = {469},
year = {2019}

RIS format (EndNote, RefMan)

AB - After injury, while regeneration can be observed in hydra, planaria and some vertebrates, regeneration is rare in mammals and particularly in humans. In this paper, we investigate the mechanisms by which biological tissues recover after injury. We explore this question on adipose tissue, using the mathematical framework recently developed in Peurichard et al., J. Theoret. Biol. 429 (2017), pp. 61-81. Our assumption is that simple mechanical cuesbetween the Extra-Cellular Matrix (ECM) and differentiated cells can explain adipose tissue morphogenesis and that regeneration requires after injury the same mechanisms. We validate this hypothesis by means of a two-dimensional Individual Based Model (IBM) of interacting adipocytes and ECM fiber elements. The model successfully generates regeneration or scar formation as functions of few key parameters, and seems to indicate that the fate of injury outcome could be mainly due to ECM rigidity
AU - Peurichard,D
AU - Ousset,M
AU - Paupert,J
AU - Aymard,B
AU - Lorsignol,A
AU - Casteilla,L
AU - Degond,P
DO - 10.1016/j.jtbi.2019.02.017
EP - 136
PY - 2019///
SN - 0022-5193
SP - 127
TI - Extra-cellular matrix rigidity may dictate the fate of injury outcome
T2 - Journal of Theoretical Biology
UR -
UR -
VL - 469
ER -