Imperial College London

ProfessorPierreDegond

Faculty of Natural SciencesDepartment of Mathematics

Chair in Applied Mathematics
 
 
 
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Contact

 

+44 (0)20 7594 1474p.degond Website CV

 
 
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Location

 

6M38Huxley BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@unpublished{Ferreira:2019:10.1101/666867,
author = {Ferreira, MA and Despin-Guitard, E and Duarte, F and Degond, P and Theveneau, E},
doi = {10.1101/666867},
publisher = {Cold Spring Harbor Laboratory},
title = {Interkinetic nuclear movements promote apical expansion in pseudostratified epithelia at the expense of apicobasal elongation},
url = {http://dx.doi.org/10.1101/666867},
year = {2019}
}

RIS format (EndNote, RefMan)

TY  - UNPB
AB - <jats:title>Abstract</jats:title><jats:p>Pseudostratified epithelia (PSE) are a common type of columnar epithelia found in a wealth of embryonic and adult tissues such as ectodermal placodes, the trachea, the ureter, the gut and the neuroepithelium. PSE are characterized by the choreographed displacement of cells’ nuclei along the apicobasal axis according to phases of their cell cycle. Such movements, called interkinetic movements (INM) have been proposed to influence tissue expansion and shape and suggested as culprit in several congenital diseases such as CAKUT and esophageal atresia. INM rely on cytoskeleton dynamics just as adhesion, contractility and mitosis do. Therefore, longer term impairment of INM without affecting proliferation and adhesion is currently technically unachievable. Here we bypassed this hurdle by generating a 2D agent-based model of a proliferating PSE and compared its output to the growth of the chick neuroepithelium to assess the interplay between INM and these other important cell processes during growth of a PSE. We found that INM directly generates apical expansion and apical nuclear crowding. In addition, our data strongly suggest that apicobasal elongation of cells is not an emerging property of a proliferative PSE but rather requires a specific elongation program. We then discuss how such program might functionally link INM, tissue growth and differentiation.</jats:p><jats:sec><jats:title>Authors Summary</jats:title><jats:p>Pseudostratified epithelia (PSE) are a common type of epithelia characterized by the choreographed displacement of cells’ nuclei along the apicobasal axis during proliferation. These so-called interkinetic movements (INM) were proposed to influence tissue expansion and suggested as culprit in several congenital diseases. INM rely on cytoskeleton dynamics. Therefore, longer term impairment of INM without affecting proliferation and adhesion is currently t
AU - Ferreira,MA
AU - Despin-Guitard,E
AU - Duarte,F
AU - Degond,P
AU - Theveneau,E
DO - 10.1101/666867
PB - Cold Spring Harbor Laboratory
PY - 2019///
TI - Interkinetic nuclear movements promote apical expansion in pseudostratified epithelia at the expense of apicobasal elongation
UR - http://dx.doi.org/10.1101/666867
ER -