Imperial College London


Faculty of Natural SciencesDepartment of Mathematics

Chair in Applied Mathematics



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BibTex format

author = {Leroy-Lerêtre, M and Dimarco, G and Cazalès, M and Boizeau, ML and Ducommun, B and Lobjois, V and Degond, PAA},
doi = {10.1007/s11538-017-0333-y},
journal = {Bulletin of Mathematical Biology},
pages = {2356--2393},
title = {Are tumor cell lineages solely shaped by mechanical forces?},
url = {},
volume = {79},
year = {2017}

RIS format (EndNote, RefMan)

AB - This paper investigates cell proliferation dynamics in small tumor cell aggregates using an individual-based model (IBM). The simulation model is designed to study the morphology of the cell population and of the cell lineages as well as the impact of the orientation of the division plane on this morphology. Our IBM model is based on the hypothesis that cells are incompressible objects that grow in size and divide once a threshold size is reached, and that newly born cell adhere to the existing cell cluster. We performed comparisons between the simulation model and experimental data by using several statistical indicators. The results suggest that the emergence of particular morphologies can be explained by simple mechanical interactions.
AU - Leroy-Lerêtre,M
AU - Dimarco,G
AU - Cazalès,M
AU - Boizeau,ML
AU - Ducommun,B
AU - Lobjois,V
AU - Degond,PAA
DO - 10.1007/s11538-017-0333-y
EP - 2393
PY - 2017///
SN - 1522-9602
SP - 2356
TI - Are tumor cell lineages solely shaped by mechanical forces?
T2 - Bulletin of Mathematical Biology
UR -
UR -
VL - 79
ER -