|2015-||Senior Lecturer, Department of Chemical Engineering, Imperial College London|
|2012-2015||Lecturer, Department of Chemical Engineering, Imperial College London|
|2010-2012||NIH/NRSA Postdoctoral Fellow, Department of Molecular Biology, Princeton University|
|2004-2010||PhD in Chemical Engineering, Department of Chemical Engineering, Princeton University|
The DiMaggio Lab is interested in the development and application of innovative experimental and computational platforms for characterizing chromatin-associated proteins and how their interactions and post-translational modifications cooperatively regulate nuclear processes, such as gene expression. At the center of our research program is liquid chromatography tandem mass spectrometry (LC-MS/MS), and our work contributes to this field on two fronts:
1. The application of fundamental chemical engineering principles towards the design, modeling and optimization of separation processes and analyte detection.
2. The development of optimization-based computational tools for robustly interpretting novel sources of LC-MS/MS data.
No positions are currently available. Please check back at a later time.
et al., 2013, A quantitative atlas of histone modification signatures from human cancer cells, Epigenetics & Chromatin, Vol:6, ISSN:1756-8935
et al., 2013, Novel Phosphorylation Sites in the S. cerevisiae Cdc13 Protein Reveal New Targets for Telomere Length Regulation, Journal of Proteome Research, Vol:12, ISSN:1535-3893, Pages:316-327
et al., 2008, Biclustering via optimal re-ordering of data matrices in systems biology: rigorous methods and comparative studies, BMC Bioinformatics, Vol:9, ISSN:1471-2105
et al., 2009, A Mixed Integer Linear Optimization Framework for the Identification and Quantification of Targeted Post-translational Modifications of Highly Modified Proteins Using Multiplexed Electron Transfer Dissociation Tandem Mass Spectrometry, Molecular & Cellular Proteomics, Vol:8, ISSN:1535-9476, Pages:2527-2543