392 results found
Asaria P, Elliott P, Douglass M, et al., Acute myocardial infarction hospitalisations and deaths in England: A national record-linkage study, The Lancet Public Health
Bentham J, NCD Risk Factor Collaboration NCD-RisC, Worldwide trends in children’s and adolescents’ body mass index, underweight, overweight and obesity, in comparison with adults, from 1975 to 2016: a pooled analysis of 2,416 population-based measurement studies with 128.9 million participants, Lancet, ISSN: 1474-547X
Kraja AT, Evangelou E, Tzoulaki I, et al., New blood pressure associated loci identified in meta-analyses of 475,000 individuals., Circulation: Cardiovascular Genetics, ISSN: 1942-325X
Wain LV, Evangelou E, Chambers JC, et al., Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney., Hypertension, ISSN: 1524-4563
Al-Dabhani K, Tsilidis KK, Murphy N, et al., 2017, Prevalence of vitamin D deficiency and association with metabolic syndrome in a Qatari population, NUTRITION & DIABETES, Vol: 7, ISSN: 2044-4052
Cai Y, Hansell AL, Blangiardo M, et al., 2017, Long-termexposure to road traffic noise, ambient air pollution, and cardiovascular risk factors in the HUNT and lifelines cohorts, EUROPEAN HEART JOURNAL, Vol: 38, Pages: 2290-+, ISSN: 0195-668X
Cai Y, Hodgson S, Blangiardo M, et al., 2017, Ambient Air Pollution, Traffic Noise And Adult-Onset Asthma: The Hunt Study, Norway, International Conference of the American-Thoracic-Society (ATS), Publisher: AMER THORACIC SOC, ISSN: 1073-449X
Cai Y, Hodgson S, Blangiardo M, et al., 2017, Road traffic noise and incident cardiovascular disease: a joint analysis of HUNT, EPIC-Oxford and UK Biobank, ICBEN Congress on Noise as a Public Health Problem, Publisher: International Commission on Biological Effects of Noise
Aims: This study aimed to investigate the effects of long-term exposure to road traffic noise on incident CVD in three large cohorts: HUNT, EPIC-Oxford and UK Biobank. Methods: In a complete-case sample (N=361,699), 4,014 IHD and 2,109 cerebrovascular incident cases were ascertained between baseline (1993-2010) and end of follow-up (2008-2015) through medical record linkage. Annual mean road traffic noise exposure was modelled at baseline address. Individual-level covariate data were harmonised and data were pooled. Analyses used Cox proportional hazards model with adjustments for confounders, including air pollution. Results: For an interquartile range (IQR) (3.9 dBA) higher daytime noise, a non-significant association with incident IHD was seen (Hazard ratio (HR): 1.015, 95% Confidence Interval (CI): 0.989-1.042), fully adjusted. Statistically significant associations and interaction terms were seen in obese individuals (HR: 1.099, 95%CI: 1.029-1.174), and current-smokers (HR: 1.054, 95%CI: 1.007-1.103). No associations were found for ischemic or hemorrhagic stroke. Conclusions: Our study strengthens the evidence base for an effect of road traffic noise on incident IHD, whilst the association with incident stroke remains unclear.
Cai Y, Zijlema WL, Doiron D, et al., 2017, Ambient air pollution, traffic noise and adult asthma prevalence: a BioSHaRE approach, EUROPEAN RESPIRATORY JOURNAL, Vol: 49, ISSN: 0903-1936
Castagné R, Boulangé CL, Karaman I, et al., 2017, Improving Visualization and Interpretation of Metabolome-Wide Association Studies: An Application in a Population-Based Cohort Using Untargeted (1)H NMR Metabolic Profiling., J Proteome Res, Vol: 16, Pages: 3623-3633
(1)H NMR spectroscopy of biofluids generates reproducible data allowing detection and quantification of small molecules in large population cohorts. Statistical models to analyze such data are now well-established, and the use of univariate metabolome wide association studies (MWAS) investigating the spectral features separately has emerged as a computationally efficient and interpretable alternative to multivariate models. The MWAS rely on the accurate estimation of a metabolome wide significance level (MWSL) to be applied to control the family wise error rate. Subsequent interpretation requires efficient visualization and formal feature annotation, which, in-turn, call for efficient prioritization of spectral variables of interest. Using human serum (1)H NMR spectroscopic profiles from 3948 participants from the Multi-Ethnic Study of Atherosclerosis (MESA), we have performed a series of MWAS for serum levels of glucose. We first propose an extension of the conventional MWSL that yields stable estimates of the MWSL across the different model parameterizations and distributional features of the outcome. We propose both efficient visualization methods and a strategy based on subsampling and internal validation to prioritize the associations. Our work proposes and illustrates practical and scalable solutions to facilitate the implementation of the MWAS approach and improve interpretation in large cohort studies.
Chan Q, Loo RL, Ebbels TMD, et al., 2017, Metabolic phenotyping for discovery of urinary biomarkers of diet, xenobiotics and blood pressure in the INTERMAP Study: an overview, HYPERTENSION RESEARCH, Vol: 40, Pages: 336-345, ISSN: 0916-9636
Chekmeneva E, Correia GDS, Chan Q, et al., 2017, Optimization and Application of Direct Infusion Nanoelectrospray HRMS Method for Large-Scale Urinary Metabolic Phenotyping in Molecular Epidemiology, JOURNAL OF PROTEOME RESEARCH, Vol: 16, Pages: 1646-1658, ISSN: 1535-3893
Douglas P, Freni-Sterrantino A, Sanchez ML, et al., 2017, Estimating Particulate Exposure from Modern Municipal Waste Incinerators in Great Britain, ENVIRONMENTAL SCIENCE & TECHNOLOGY, Vol: 51, Pages: 7511-7519, ISSN: 0013-936X
Garcia-Perez I, Posma JM, Gibson R, et al., 2017, Objective assessment of dietary patterns by use of metabolic phenotyping: a randomised, controlled, crossover trial, LANCET DIABETES & ENDOCRINOLOGY, Vol: 5, Pages: 184-195, ISSN: 2213-8587
Gibson R, Eriksen R, Lamb K, et al., 2017, Dietary assessment of British police force employees: a description of diet record coding procedures and cross-sectional evaluation of dietary energy intake reporting (The Airwave Health Monitoring Study), BMJ OPEN, Vol: 7, ISSN: 2044-6055
Koyama T, Yoshita K, Okuda N, et al., 2017, Overall nutrient and total fat intake among Japanese people: The INTERLIPID Study Japan, ASIA PACIFIC JOURNAL OF CLINICAL NUTRITION, Vol: 26, Pages: 837-848, ISSN: 0964-7058
Manning A, Highland HM, Gasser J, et al., 2017, A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk, DIABETES, Vol: 66, Pages: 2019-2032, ISSN: 0012-1797
Marouli E, Graff M, Medina-Gomez C, et al., 2017, Rare and low-frequency coding variants alter human adult height, NATURE, Vol: 542, Pages: 186-190, ISSN: 0028-0836
Mousas A, Ntritsos G, Chen M-H, et al., 2017, Rare coding variants pinpoint genes that control human hematological traits, PLOS GENETICS, Vol: 13, ISSN: 1553-7404
Neal B, Tian M, Li N, et al., 2017, Rationale, design, and baseline characteristics of the Salt Substitute and Stroke Study (SSaSS)-A large-scale cluster randomized controlled trial, AMERICAN HEART JOURNAL, Vol: 188, Pages: 109-117, ISSN: 0002-8703
Okuda N, Okayama A, Miura K, et al., 2017, Food sources of dietary sodium in the Japanese adult population: the international study of macro-/micronutrients and blood pressure (INTERMAP), EUROPEAN JOURNAL OF NUTRITION, Vol: 56, Pages: 1269-1280, ISSN: 1436-6207
Pertiwi K, Oude Griep LM, Stamler J, et al., 2017, Relationship of potato consumption, total and by preparation method with blood pressure and body mass index: The International Population Study on Macronutrients and Blood Pressure (INTERMAP) US study, Scientific Sessions on Epidemiology and Prevention, Lifestyle and Cardiometabolic Health of the American Hearth Association, Publisher: American Heart Association, Pages: AP272-AP272, ISSN: 0009-7322
Background: Limited evidence from prospective US cohort studies suggests that higher potato intake is associated with a higher risk of hypertension and obesity. Different preparation methods affect the nutritional composition of potatoes and are related to different dietary choices that may influence associations with blood pressure and body mass index (BMI).Objective: To investigate potato consumption, total and by preparation method, in relation to blood pressure and BMI.Methods: We used cross-sectional data of 2,195 participants aged 40 to 59 in 1996-1997 from the United States samples of the population-based INTERMAP study. During four visits, four in-depth multipass 24-hour dietary recalls and eight blood pressure measurements were collected. Reported potato intakes were categorized as fried and non-fried potatoes, using the USDA food grouping system. Potato intakes (g/1000 kcal) were averaged over four days. Regression coefficients per 2SD higher intake were estimated using multivariate linear regression analyses with adjustments for age, sex, sample, lifestyle and disease factors, and other food groups. To assess influence on the association, diet quality (by Dietary Approaches to Stop Hypertension adherence score), BMI, urinary sodium and potassium were added separately to the previous model.Results: Median intake of total, non-fried, and fried potatoes were 40 g/d, 23 g/d and 8 g/d, respectively. Total and non-fried potato intakes were not associated with blood pressure. The association between fried potatoes and blood pressure varied by sex (P for interaction=0.03).In women, higher fried potato intake (2SD: 20 g/1000 kcal) was associated with a +3.00 mmHg (95%CI: 1.29, 4.71) higher systolic and +1.26 mmHg (95%CI: 0.15, 2.38) higher diastolic blood pressure, which prevailed after additional, but separate, adjustments for BMI, diet quality, urinary sodium and potassium. Potato chips contributed predominantly (79%) to fried potato intake and accounted for the
Scheelbeek P, Chowdhury MAH, Haines A, et al., 2017, Drinking Water Salinity and Raised Blood Pressure: Evidence from a Cohort Study in Coastal Bangladesh., Environ Health Perspect, Vol: 125
BACKGROUND: Millions of coastal inhabitants in Southeast Asia have been experiencing increasing sodium concentrations in their drinking-water sources, likely partially due to climate change. High (dietary) sodium intake has convincingly been proven to increase risk of hypertension; it remains unknown, however, whether consumption of sodium in drinking water could have similar effects on health. OBJECTIVES: We present the results of a cohort study in which we assessed the effects of drinking-water sodium (DWS) on blood pressure (BP) in coastal populations in Bangladesh. METHODS: DWS, BP, and information on personal, lifestyle, and environmental factors were collected from 581 participants. We used generalized linear latent and mixed methods to model the effects of DWS on BP and assessed the associations between changes in DWS and BP when participants experienced changing sodium levels in water, switched from "conventional" ponds or tube wells to alternatives [managed aquifer recharge (MAR) and rainwater harvesting] that aimed to reduce sodium levels, or experienced a combination of these changes. RESULTS: DWS concentrations were highly associated with BP after adjustments for confounding factors. Furthermore, for each 100 mg/L reduction in sodium in drinking water, systolic/diastolic BP was lower on average by 0.95/0.57 mmHg, and odds of hypertension were lower by 14%. However, MAR did not consistently lower sodium levels. CONCLUSIONS: DWS is an important source of daily sodium intake in salinity-affected areas and is a risk factor for hypertension. Considering the likely increasing trend in coastal salinity, prompt action is required. Because MAR showed variable effects, alternative technologies for providing reliable, safe, low-sodium fresh water should be developed alongside improvements in MAR and evaluated in "real-life" salinity-affected settings. https://doi.org/10.1289/EHP659.
Schierding W, Antony J, Karhunen V, et al., 2017, GWAS on prolonged gestation (post-term birth): analysis of successive Finnish birth cohorts., J Med Genet
BACKGROUND: Gestation is a crucial timepoint in human development. Deviation from a term gestational age correlates with both acute and long-term adverse health effects for the child. Both being born preterm and post-term, that is, having short and long gestational ages, are heritable and influenced by the prenatal and perinatal environment. Despite the obvious heritable component, specific genetic influences underlying differences in gestational age are poorly understood. METHODS: We investigated the genetic architecture of gestational age in 9141 individuals, including 1167 born post-term, across two Northern Finland cohorts born in 1966 or 1986. RESULTS: Here we identify one globally significant intronic genetic variant within the ADAMTS13 gene that is associated with prolonged gestation (p=4.85×10(-8)). Additional variants that reached suggestive levels of significance were identified within introns at the ARGHAP42 and TKT genes, and in the upstream (5') intergenic regions of the B3GALT5 and SSBP2 genes. The variants near the ADAMTS13, B3GALT5, SSBP2 and TKT loci are linked to alterations in gene expression levels (cis-eQTLs). Luciferase assays confirmed the allele specific enhancer activity for the BGALT5 and TKT loci. CONCLUSIONS: Our findings provide the first evidence of a specific genetic influence associated with prolonged gestation. This study forms a foundation for a better understanding of the genetic and long-term health risks faced by induced and post-term individuals. The long-term risks for induced individuals who have a previously overlooked post-term potential may be a major issue for current health providers.
Stringhini S, Carmeli C, Jokela M, et al., 2017, Socioeconomic status and the 25 x 25 risk factors as determinants of premature mortality: a multicohort study and meta-analysis of 1.7 million men and women, LANCET, Vol: 389, Pages: 1229-1237, ISSN: 0140-6736
Toledano MB, Auvinen A, Tettamanti G, et al., 2017, An international prospective cohort study of mobile phone users and health (COSMOS): factors affecting validity of self-reported mobile phone use, International Journal of Hygiene and Environmental Health, ISSN: 1438-4639
Toledano MB, Smith RB, Chang I, et al., 2017, Cohort Profile: UK COSMOS-a UK cohort for study of environment and health, INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, Vol: 46, Pages: 775-787, ISSN: 0300-5771
Wahl S, Drong A, Lehne B, et al., 2017, Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity, NATURE, Vol: 541, Pages: 81-+, ISSN: 0028-0836
Wain LV, Vaez A, Jansen R, et al., 2017, Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney, HYPERTENSION, Vol: 70, Pages: E4-+, ISSN: 0194-911X
Warren HR, Evangelou E, Cabrera CP, et al., 2017, Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk, NATURE GENETICS, Vol: 49, Pages: 403-415, ISSN: 1061-4036
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