Imperial College London
Alternate

ProfessorPaulElliott

Faculty of Medicine, School of Public Health

Chair in Epidemiology and Public Health Medicine
 
 
 
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Contact

 

+44 (0)20 7594 3328p.elliott Website

 
 
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Assistant

 

Miss Jennifer Wells +44 (0)20 7594 3328

 
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Location

 

154Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Davies:2018:10.1038/s41467-018-04362-x,
author = {Davies, G and Lam, M and Harris, SE and Trampush, JW and Luciano, M and Hill, WD and Hagenaars, SP and Ritchie, SJ and Marioni, RE and Fawns-Ritchie, C and Liewald, DCM and Okely, JA and Ahola-Olli, AV and Barnes, CLK and Bertram, L and Bis, JC and Burdick, KE and Christoforou, A and DeRosse, P and Djurovic, S and Espeseth, T and Giakoumaki, S and Giddaluru, S and Gustavson, DE and Hayward, C and Hofer, E and Ikram, MA and Karlsson, R and Knowles, E and Lahti, J and Leber, M and Li, S and Mather, KA and Melle, I and Morris, D and Oldmeadow, C and Palviainen, T and Payton, A and Pazoki, R and Petrovic, K and Reynolds, CA and Sargurupremraj, M and Scholz, M and Smith, JA and Smith, AV and Terzikhan, N and Thalamuthu, A and Trompet, S and van, der Lee SJ and Ware, EB and Windham, BG and Wright, MJ and Yang, J and Yu, J and Ames, D and Amin, N and Amouyel, P and Andreassen, OA and Armstrong, NJ and Assareh, AA and Attia, JR and Attix, D and Avramopoulos, D and Bennett, DA and Boehmer, AC a},
doi = {10.1038/s41467-018-04362-x},
journal = {Nature Communications},
title = {Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function},
url = {http://dx.doi.org/10.1038/s41467-018-04362-x},
volume = {9},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - General cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank (total N = 300,486; age 16–102) and find 148 genome-wide significant independent loci (P < 5 × 10−8) associated with general cognitive function. Within the novel genetic loci are variants associated with neurodegenerative and neurodevelopmental disorders, physical and psychiatric illnesses, and brain structure. Gene-based analyses find 709 genes associated with general cognitive function. Expression levels across the cortex are associated with general cognitive function. Using polygenic scores, up to 4.3% of variance in general cognitive function is predicted in independent samples. We detect significant genetic overlap between general cognitive function, reaction time, and many health variables including eyesight, hypertension, and longevity. In conclusion we identify novel genetic loci and pathways contributing to the heritability of general cognitive function.
AU  - Davies,G
AU  - Lam,M
AU  - Harris,SE
AU  - Trampush,JW
AU  - Luciano,M
AU  - Hill,WD
AU  - Hagenaars,SP
AU  - Ritchie,SJ
AU  - Marioni,RE
AU  - Fawns-Ritchie,C
AU  - Liewald,DCM
AU  - Okely,JA
AU  - Ahola-Olli,AV
AU  - Barnes,CLK
AU  - Bertram,L
AU  - Bis,JC
AU  - Burdick,KE
AU  - Christoforou,A
AU  - DeRosse,P
AU  - Djurovic,S
AU  - Espeseth,T
AU  - Giakoumaki,S
AU  - Giddaluru,S
AU  - Gustavson,DE
AU  - Hayward,C
AU  - Hofer,E
AU  - Ikram,MA
AU  - Karlsson,R
AU  - Knowles,E
AU  - Lahti,J
AU  - Leber,M
AU  - Li,S
AU  - Mather,KA
AU  - Melle,I
AU  - Morris,D
AU  - Oldmeadow,C
AU  - Palviainen,T
AU  - Payton,A
AU  - Pazoki,R
AU  - Petrovic,K
AU  - Reynolds,CA
AU  - Sargurupremraj,M
AU  - Scholz,M
AU  - Smith,JA
AU  - Smith,AV
AU  - Terzikhan,N
AU  - Thalamuthu,A
AU  - Trompet,S
AU  - van,der Lee SJ
AU  - Ware,EB
AU  - Windham,BG
AU  - Wright,MJ
AU  - Yang,J
AU  - Yu,J
AU  - Ames,D
AU  - Amin,N
AU  - Amouyel,P
AU  - Andreassen,OA
AU  - Armstrong,NJ
AU  - Assareh,AA
AU  - Attia,JR
AU  - Attix,D
AU  - Avramopoulos,D
AU  - Bennett,DA
AU  - Boehmer,AC
AU  - Boyle,PA
AU  - Brodaty,H
AU  - Campbell,H
AU  - Cannon,TD
AU  - Cirulli,ET
AU  - Congdon,E
AU  - Conley,ED
AU  - Corley,J
AU  - Cox,SR
AU  - Dale,AM
AU  - Dehghan,A
AU  - Dick,D
AU  - Dickinson,D
AU  - Eriksson,JG
AU  - Evangelou,E
AU  - Faul,JD
AU  - Ford,I
AU  - Freimer,NA
AU  - Gao,H
AU  - Giegling,I
AU  - Gillespie,NA
AU  - Gordon,SD
AU  - Gottesman,RF
AU  - Griswold,ME
AU  - Gudnason,V
AU  - Harris,TB
AU  - Hartmann,AM
AU  - Hatzimanolis,A
AU  - Heiss,G
AU  - Holliday,EG
AU  - Joshi,PK
AU  - Kahonen,M
AU  - Kardia,SLR
AU  - Karlsson,I
AU  - Kleineidam,L
AU  - Knopman,DS
AU  - Kochan,NA
AU  - Konte,B
AU  - Kwok,JB
AU  - Le,Hellard S
AU  - Lee,T
AU  - Lehtimaki,T
AU  - Li,S-C
AU  - Liu,T
AU  - Koini,M
AU  - London,E
AU  - Longstreth,WT
AU  - Lopez,OL
AU  - Loukola,A
AU  - Luck,T
AU  - Lundervold,AJ
AU  - Lundquist,A
AU  - Lyytikainen,L-P
AU  - Martin,NG
AU  - Montgomery,GW
AU  - Murray,AD
AU  - Need,AC
AU  - Noordam,R
AU  - Nyberg,L
AU  - Ollier,W
AU  - Papenberg,G
AU  - Pattie,A
AU  - Polasek,O
AU  - Poldrack,RA
AU  - Psaty,BM
AU  - Reppermund,S
AU  - Riedel-Heller,SG
AU  - Rose,RJ
AU  - Rotter,JI
AU  - Roussos,P
AU  - Rovio,SP
AU  - Saba,Y
AU  - Sabb,FW
AU  - Sachdev,PS
AU  - Satizabal,CL
AU  - Schmid,M
AU  - Scott,RJ
AU  - Scult,MA
AU  - Simino,J
AU  - Slagboom,PE
AU  - Smyrnis,N
AU  - Soumare,A
AU  - Stefanis,NC
AU  - Stott,DJ
AU  - Straub,RE
AU  - Sundet,K
AU  - Taylor,AM
AU  - Taylor,KD
AU  - Tzoulaki,I
AU  - Tzourio,C
AU  - Uitterlinden,A
AU  - Vitart,V
AU  - Voineskos,AN
AU  - Kaprio,J
AU  - Wagner,M
AU  - Wagner,H
AU  - Weinhold,L
AU  - Wen,KH
AU  - Widen,E
AU  - Yang,Q
AU  - Zhao,W
AU  - Adams,HHH
AU  - Arking,DE
AU  - Bilder,RM
AU  - Bitsios,P
AU  - Boerwinkle,E
AU  - Chiba-Falek,O
AU  - Corvin,A
AU  - De,Jager PL
AU  - Debette,S
AU  - Donohoe,G
AU  - Elliott,P
AU  - Fitzp
DO  - 10.1038/s41467-018-04362-x
PY  - 2018///
SN  - 2041-1723
TI  - Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function
T2  - Nature Communications
UR  - http://dx.doi.org/10.1038/s41467-018-04362-x
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000433297900009&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/60547
VL  - 9
ER  -
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