Imperial College London
Alternate

ProfessorPaulElliott

Faculty of Medicine, School of Public Health

Chair in Epidemiology and Public Health Medicine
 
 
 
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Contact

 

+44 (0)20 7594 3328p.elliott Website

 
 
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Assistant

 

Miss Jennifer Wells +44 (0)20 7594 3328

 
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Location

 

154Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Middeldorp:2019:10.1007/s10654-019-00502-9,
author = {Middeldorp, CM and Felix, JF and Mahajan, A and McCarthy, MI and EArly, Genetics Lifecourse Epidemiology EAGLE consortium and Early, Growth Genetics EGG and Rodriguez, A},
doi = {10.1007/s10654-019-00502-9},
journal = {European Journal of Epidemiology},
pages = {279--300},
title = {The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia: design, results and future prospects},
url = {http://dx.doi.org/10.1007/s10654-019-00502-9},
volume = {34},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The impact of many unfavorable childhood traits or diseases, such as low birth weight and mental disorders, is not limited to childhood and adolescence, as they are also associated with poor outcomes in adulthood, such as cardiovascular disease. Insight into the genetic etiology of childhood and adolescent traits and disorders may therefore provide new perspectives, not only on how to improve wellbeing during childhood, but also how to prevent later adverse outcomes. To achieve the sample sizes required for genetic research, the Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia were established. The majority of the participating cohorts are longitudinal population-based samples, but other cohorts with data on early childhood phenotypes are also involved. Cohorts often have a broad focus and collect(ed) data on various somatic and psychiatric traits as well as environmental factors. Genetic variants have been successfully identified for multiple traits, for example, birth weight, atopic dermatitis, childhood BMI, allergic sensitization, and pubertal growth. Furthermore, the results have shown that genetic factors also partly underlie the association with adult traits. As sample sizes are still increasing, it is expected that future analyses will identify additional variants. This, in combination with the development of innovative statistical methods, will provide detailed insight on the mechanisms underlying the transition from childhood to adult disorders. Both consortia welcome new collaborations. Policies and contact details are available from the corresponding authors of this manuscript and/or the consortium websites.
AU  - Middeldorp,CM
AU  - Felix,JF
AU  - Mahajan,A
AU  - McCarthy,MI
AU  - EArly,Genetics Lifecourse Epidemiology EAGLE consortium
AU  - Early,Growth Genetics EGG
AU  - Rodriguez,A
DO  - 10.1007/s10654-019-00502-9
EP  - 300
PY  - 2019///
SN  - 0393-2990
SP  - 279
TI  - The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia: design, results and future prospects
T2  - European Journal of Epidemiology
UR  - http://dx.doi.org/10.1007/s10654-019-00502-9
UR  - http://hdl.handle.net/10044/1/67993
VL  - 34
ER  -
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