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@article{Wuttke:2019:10.1038/s41588-019-0407-x,
author = {Wuttke, M and Li, Y and Li, M and Sieber, KB and Feitosa, MF and Gorski, M and Tin, A and Wang, L and Chu, AY and Hoppmann, A and Kirsten, H and Giri, A and Chai, J-F and Sveinbjornsson, G and Tayo, BO and Nutile, T and Fuchsberger, C and Marten, J and Cocca, M and Ghasemi, S and Xu, Y and Horn, K and Noce, D and Van, der Most PJ and Sedaghat, S and Yu, Z and Akiyama, M and Afaq, S and Ahluwalia, TS and Almgren, P and Amin, N and Arnlov, J and Bakker, SJL and Bansal, N and Baptista, D and Bergmann, S and Biggs, ML and Biino, G and Boehnke, M and Boerwinkle, E and Boissel, M and Bottinger, EP and Boutin, TS and Brenner, H and Brumat, M and Burkhardt, R and Butterworth, AS and Campana, E and Campbell, A and Campbell, H and Canouil, M and Carroll, RJ and Catamo, E and Chambers, JC and Chee, M-L and Chee, M-L and Chen, X and Cheng, C-Y and Cheng, Y and Christensen, K and Cifkova, R and Ciullo, M and Concas, MP and Cook, JP and Coresh, J and Corre, T and Sala, CF and Cusi, D and Danesh, J a},
doi = {10.1038/s41588-019-0407-x},
journal = {Nature Genetics},
pages = {957--972},
title = {A catalog of genetic loci associated with kidney function from analyses of a million individuals},
url = {http://dx.doi.org/10.1038/s41588-019-0407-x},
volume = {51},
year = {2019}
}

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TY  - JOUR
AB  - Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through trans-ancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication (n = 1,046,070), we identified 264 associated loci (166 new). Of these, 147 were likely to be relevant for kidney function on the basis of associations with the alternative kidney function marker blood urea nitrogen (n = 416,178). Pathway and enrichment analyses, including mouse models with renal phenotypes, support the kidney as the main target organ. A genetic risk score for lower eGFR was associated with clinically diagnosed CKD in 452,264 independent individuals. Colocalization analyses of associations with eGFR among 783,978 European-ancestry individuals and gene expression across 46 human tissues, including tubulo-interstitial and glomerular kidney compartments, identified 17 genes differentially expressed in kidney. Fine-mapping highlighted missense driver variants in 11 genes and kidney-specific regulatory variants. These results provide a comprehensive priority list of molecular targets for translational research.
AU  - Wuttke,M
AU  - Li,Y
AU  - Li,M
AU  - Sieber,KB
AU  - Feitosa,MF
AU  - Gorski,M
AU  - Tin,A
AU  - Wang,L
AU  - Chu,AY
AU  - Hoppmann,A
AU  - Kirsten,H
AU  - Giri,A
AU  - Chai,J-F
AU  - Sveinbjornsson,G
AU  - Tayo,BO
AU  - Nutile,T
AU  - Fuchsberger,C
AU  - Marten,J
AU  - Cocca,M
AU  - Ghasemi,S
AU  - Xu,Y
AU  - Horn,K
AU  - Noce,D
AU  - Van,der Most PJ
AU  - Sedaghat,S
AU  - Yu,Z
AU  - Akiyama,M
AU  - Afaq,S
AU  - Ahluwalia,TS
AU  - Almgren,P
AU  - Amin,N
AU  - Arnlov,J
AU  - Bakker,SJL
AU  - Bansal,N
AU  - Baptista,D
AU  - Bergmann,S
AU  - Biggs,ML
AU  - Biino,G
AU  - Boehnke,M
AU  - Boerwinkle,E
AU  - Boissel,M
AU  - Bottinger,EP
AU  - Boutin,TS
AU  - Brenner,H
AU  - Brumat,M
AU  - Burkhardt,R
AU  - Butterworth,AS
AU  - Campana,E
AU  - Campbell,A
AU  - Campbell,H
AU  - Canouil,M
AU  - Carroll,RJ
AU  - Catamo,E
AU  - Chambers,JC
AU  - Chee,M-L
AU  - Chee,M-L
AU  - Chen,X
AU  - Cheng,C-Y
AU  - Cheng,Y
AU  - Christensen,K
AU  - Cifkova,R
AU  - Ciullo,M
AU  - Concas,MP
AU  - Cook,JP
AU  - Coresh,J
AU  - Corre,T
AU  - Sala,CF
AU  - Cusi,D
AU  - Danesh,J
AU  - Daw,EW
AU  - De,Borst MH
AU  - De,Grandi A
AU  - De,Mutsert R
AU  - De,Vries APJ
AU  - Degenhardt,F
AU  - Delgado,G
AU  - Demirkan,A
AU  - Di,Angelantonio E
AU  - Dittrich,K
AU  - Divers,J
AU  - Dorajoo,R
AU  - Eckardt,K-U
AU  - Ehret,G
AU  - Elliott,P
AU  - Endlich,K
AU  - Evans,MK
AU  - Felix,JF
AU  - Foo,VHX
AU  - Franco,OH
AU  - Franke,A
AU  - Freedman,BI
AU  - Freitag-Wolf,S
AU  - Friedlander,Y
AU  - Froguel,P
AU  - Gansevoort,RT
AU  - Gao,H
AU  - Gasparini,P
AU  - Gaziano,JM
AU  - Giedraitis,V
AU  - Gieger,C
AU  - Girotto,G
AU  - Giulianini,F
AU  - Gogele,M
AU  - Gordon,SD
AU  - Gudbjartsson,DF
AU  - Gudnason,V
AU  - Haller,T
AU  - Hamet,P
AU  - Harris,TB
AU  - Hartman,CA
AU  - Hayward,C
AU  - Hellwege,JN
AU  - Heng,C-K
AU  - Hicks,AA
AU  - Hofer,E
AU  - Huang,W
AU  - Hutri-Kahonen,N
AU  - Hwang,S-J
AU  - Ikram,MA
AU  - Indridason,OS
AU  - Ingelsson,E
AU  - Ising,M
AU  - Jaddoe,VWV
AU  - Jakobsdottir,J
AU  - Jonas,JB
AU  - Joshi,PK
AU  - Josyula,NS
AU  - Jung,B
AU  - Kahonen,M
AU  - Kamatani,Y
AU  - Kammerer,CM
AU  - Kanai,M
AU  - Kastarinen,M
AU  - Kerr,SM
AU  - Khor,C-C
AU  - Kiess,W
AU  - Kleber,ME
AU  - Koenig,W
AU  - Kooner,JS
AU  - Korner,A
AU  - Kovacs,P
AU  - Kraja,AT
AU  - Krajcoviechova,A
AU  - Kramer,H
AU  - Kramer,BK
AU  - Kronenberg,F
AU  - Kubo,M
AU  - Kuhnel,B
AU  - Kuokkanen,M
AU  - Kuusisto,J
AU  - La,Bianca M
AU  - Laakso,M
AU  - Lange,LA
AU  - Langefeld,CD
AU  - Lee,JJ-M
AU  - Lehne,B
AU  - Lehtimaki,T
AU  - Lieb,W
AU  - Lim,S-C
AU  - Lind,L
AU  - Lindgren,CM
AU  - Liu,J
AU  - Liu,J
AU  - Loeffler,M
AU  - Loos,RJF
AU  - Lucae,S
AU  - Lukas,MA
AU  - Lyytikainen,L-P
AU  - Magi,R
AU  - Magnusson,PKE
AU  - Mahajan,A
AU  - Martin,NG
AU  - Martins,J
AU  - Marz,W
AU  - Mascalzoni,D
AU  - Matsuda,K
AU  - Meisinger,C
AU  - Meitinger,T
AU  - Melander,O
AU  - Metspalu,A
AU  - Mikaels
DO  - 10.1038/s41588-019-0407-x
EP  - 972
PY  - 2019///
SN  - 1061-4036
SP  - 957
TI  - A catalog of genetic loci associated with kidney function from analyses of a million individuals
T2  - Nature Genetics
UR  - http://dx.doi.org/10.1038/s41588-019-0407-x
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000469996900008&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/70965
VL  - 51
ER  -

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