Imperial College London
Alternate

ProfessorPaulElliott

Faculty of Medicine, School of Public Health

Chair in Epidemiology and Public Health Medicine
 
 
 
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Contact

 

+44 (0)20 7594 3328p.elliott Website

 
 
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Assistant

 

Miss Jennifer Wells +44 (0)20 7594 3328

 
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Location

 

154Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Seow:2019:10.1001/jamanetworkopen.2019.11970,
author = {Seow, WJ and Shu, X and Nicholson, J and Holmes, E and Walker, DI and Hu, W and Cai, Q and Gao, Y-T and Xiang, Y-B and Moore, S and Bassig, BA and Wong, JYY and Zhang, J and Ji, B-T and Boulange, C and Kaluarachchi, M and Wijeyesekera, A and Zheng, W and Elliott, P and Rothman, N and Lan, Q},
doi = {10.1001/jamanetworkopen.2019.11970},
journal = {JAMA Network Open},
title = {Association of untargeted urinary metabolomics and lung cancer risk among never-smoking women in China.},
url = {http://dx.doi.org/10.1001/jamanetworkopen.2019.11970},
volume = {2},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Importance  Chinese women have the highest rate of lung cancer among female never-smokers in the world, and the etiology is poorly understood.Objective  To assess the association between metabolomics and lung cancer risk among never-smoking women.Design, Setting, and Participants  This nested case-control study included 275 never-smoking female patients with lung cancer and 289 never-smoking cancer-free control participants from the prospective Shanghai Women’s Health Study recruited from December 28, 1996, to May 23, 2000. Validated food frequency questionnaires were used for the collection of dietary information. Metabolomic analysis was conducted from November 13, 2015, to January 6, 2016. Data analysis was conducted from January 6, 2016, to November 29, 2018.Exposures  Untargeted ultra-high-performance liquid chromatography–tandem mass spectrometry and nuclear magnetic resonance metabolomic profiles were characterized using prediagnosis urine samples. A total of 39416 metabolites were measured.Main Outcomes and Measures  Incident lung cancer.Results  Among the 564 women, those who developed lung cancer (275 participants; median [interquartile range] age, 61.0 [52-65] years) and those who did not develop lung cancer (289 participants; median [interquartile range] age, 62.0 [53-66] years) at follow-up (median [interquartile range] follow-up, 10.9 [9.0-11.7] years) were similar in terms of their secondhand smoke exposure, history of respiratory diseases, and body mass index. A peak metabolite, identified as 5-methyl-2-furoic acid, was significantly associated with lower lung cancer risk (odds ratio, 0.57 [95% CI, 0.46-0.72]; P < .001; false discovery rate = 0.039). Furthermore, this peak was weakly correlated with self-reported dietary soy intake (ρ = 0.21; P < .001). Increasing tertiles of this metabolite were associated with lower lung cancer risk (in comparison with first tertile, odd
AU  - Seow,WJ
AU  - Shu,X
AU  - Nicholson,J
AU  - Holmes,E
AU  - Walker,DI
AU  - Hu,W
AU  - Cai,Q
AU  - Gao,Y-T
AU  - Xiang,Y-B
AU  - Moore,S
AU  - Bassig,BA
AU  - Wong,JYY
AU  - Zhang,J
AU  - Ji,B-T
AU  - Boulange,C
AU  - Kaluarachchi,M
AU  - Wijeyesekera,A
AU  - Zheng,W
AU  - Elliott,P
AU  - Rothman,N
AU  - Lan,Q
DO  - 10.1001/jamanetworkopen.2019.11970
PY  - 2019///
SN  - 2574-3805
TI  - Association of untargeted urinary metabolomics and lung cancer risk among never-smoking women in China.
T2  - JAMA Network Open
UR  - http://dx.doi.org/10.1001/jamanetworkopen.2019.11970
UR  - http://hdl.handle.net/10044/1/73154
VL  - 2
ER  -
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