Imperial College London

ProfessorPaulFarrell

Faculty of MedicineDepartment of Medicine

Professor of Tumour Virology
 
 
 
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Contact

 

+44 (0)20 7594 2005p.farrell Website

 
 
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Location

 

Section of VirologyNorfolk PlaceSt Mary's Campus

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Summary

 

Summary

Paul Farrell's research is mostly on mechanisms by which the human tumour virus Epstein-Barr Virus causes human cells to proliferate and the role of the virus in human cancers.

Download a copy of the EBV genetic map  EBV map (pdf file)

Epstein-Barr virus is a human herpesvirus that infects most people in the world early in life and then persists life-long. Primary EBV infection that is delayed until adolescence or adulthood frequently causes infectious mononucleosis (glandular fever). Most carriers of EBV show no symptoms or pathology but in some circumstances EBV is associated with human cancers, the virus normally being present in all of the tumour cells of an EBV associated case. These cancers include lymphomas in immunosuppressed people (either as a result of medication after transplant surgery or AIDS), Hodgkin's disease, Burkitt's lymphoma in central Africa, nasopharyngeal carcinoma in South-East Asia and some gastric carcinomas. EBV infects human B lymphocytes and certain epithelial cells; infection of lymphocytes is readily accomplished in the laboratory and EBV drives the cells into a state of permanent proliferation.

Paul Farrell acted as Head of Molecular Virology at Imperial College 1996-2000 and 2011-2018. He was also Director of the London St Mary's branch of Ludwig Institute for Cancer Research 1986-2005, at the same location. From 2009 - 2016 he chaired the Research Grants committee for the Leukaemia and Lymphoma Research charity (now called Bloodwise). 

Current research is focussed on

Superior B cell transformation by type 1 EBV

Worldwide EBV sequence variation

Roles of RUNX genes in human B cells

More details are on my Research Page

     

       

        Publications

        Journals

        Farrell PJ, 2019, Epstein-Barr Virus and Cancer., Annu Rev Pathol, Vol:14, Pages:29-53

        Paschos K, Bazot Q, Lees J, et al., 2019, Requirement for PRC1 subunit BMI1 in host gene activation by Epstein-Barr virus protein EBNA3C., Nucleic Acids Res

        Bridges R, Correia S, Wegner F, et al., Essential role of inverted repeat in Epstein-Barr Virus IR-1 in B cell transformation; geographic variation of the viral genome, Philosophical Transactions B: Biological Sciences, ISSN:0962-8436

        Correia S, Bridges R, Wegner F, et al., 2018, Sequence variation of Epstein-Barr virus: viral types, geography, codon usage and diseases, Journal of Virology, Vol:92, ISSN:1098-5514

        Bristol JA, Djavadian R, Albright ER, et al., 2018, A cancer-associated Epstein-Barr virus BZLF1 promoter variant enhances lytic infection, Plos Pathogens, Vol:14, ISSN:1553-7366

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