Imperial College London

ProfessorPaulFarrell

Faculty of MedicineDepartment of Infectious Disease

Professor of Tumour Virology
 
 
 
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Contact

 

+44 (0)20 7594 2005p.farrell Website

 
 
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Location

 

Section of VirologyNorfolk PlaceSt Mary's Campus

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Summary

 

Publications

Publication Type
Year
to

155 results found

Lai IY-C, Farrell PJ, Kellam P, 2011, X-box binding protein 1 induces the expression of the lytic cycle transactivator of Kaposi's sarcoma-associated herpesvirus but not Epstein Barr virus in co-infected primary effusion lymphoma, Journal of General Virology, Vol: 92, Pages: 421-431, ISSN: 1465-2099

Cells of primary effusion lymphoma (PEL), a B-cell non-Hodgkin's lymphoma, are latently infected by Kaposi's sarcoma-associated herpesvirus (KSHV), with about 80 % of PEL also co-infected with Epstein–Barr virus (EBV). Both viruses can be reactivated into their lytic replication cycle in PEL by chemical inducers. However, simultaneous activation of both lytic cascades leads to mutual lytic cycle co-repression. The plasma cell-differentiation factor X-box binding protein 1 (XBP-1) transactivates the KSHV immediate–early promoter leading to the production of the replication and transcription activator protein (RTA), and reactivation of KSHV from latency. XBP-1 has been reported to act similarly on the EBV immediate–early promoter Zp, leading to the production of the lytic-cycle transactivator protein BZLF1. Here we show that activated B-cell terminal-differentiation transcription factor X-box binding protein 1 (XBP-1s) does not induce EBV BZLF1 and BRLF1 expression in PEL and BL cell lines, despite inducing lytic reactivation of KSHV in PEL. We show that XBP-1s transactivates the KSHV RTA promoter but does not transactivate the EBV BZLF1 promoter in non-B-cells by using a luciferase assay. Co-expression of activated protein kinase D, which can phosphorylate and inactivate class II histone deacetylases (HDACs), does not rescue XBP-1 activity on Zp nor does it induce BZLF1 and BRLF1 expression in PEL. Finally, chemical inducers of KSHV and EBV lytic replication in PEL, including HDAC inhibitors, do not lead to XBP-1 activation. We conclude that XBP-1 specifically reactivates the KSHV lytic cycle in dually infected PELs.

Journal article

McDonald C, Karstegl CE, Kellam P, Farrell PJet al., 2010, Regulation of the Epstein-Barr virus Zp promoter in B lymphocytes during reactivation from latency, JOURNAL OF GENERAL VIROLOGY, Vol: 91, Pages: 622-629, ISSN: 0022-1317

Journal article

Brady G, Farrell PJ, 2009, RUNX3-Mediated Repression of RUNX1 in B Cells, JOURNAL OF CELLULAR PHYSIOLOGY, Vol: 221, Pages: 283-287, ISSN: 0021-9541

Journal article

Brady G, Whiteman HJ, Spender LC, Farrell PJet al., 2009, Downregulation of RUNX1 by RUNX3 Requires the RUNX3 VWRPY Sequence and Is Essential for Epstein-Barr Virus-Driven B-Cell Proliferation, JOURNAL OF VIROLOGY, Vol: 83, Pages: 6909-6916, ISSN: 0022-538X

Journal article

McDonald CM, Petosa C, Farrell PJ, 2009, Interaction of Epstein-Barr Virus BZLF1 C-Terminal Tail Structure and Core Zipper Is Required for DNA Replication but Not for Promoter Transactivation, JOURNAL OF VIROLOGY, Vol: 83, Pages: 3397-3401, ISSN: 0022-538X

Journal article

Al-Mozaini M, Bodelon G, Karstegl CE, Jin B, Al-Ahdal M, Farrell PJet al., 2009, Epstein-Barr virus BART gene expression, JOURNAL OF GENERAL VIROLOGY, Vol: 90, Pages: 307-316, ISSN: 0022-1317

Journal article

Lucchesi W, Brady G, Dittrich-Breiholz O, Kracht M, Russ R, Farrell PJet al., 2008, Differential gene regulation by Epstein-Barr virus type 1 and type 2 EBNA2, JOURNAL OF VIROLOGY, Vol: 82, Pages: 7456-7466, ISSN: 0022-538X

Journal article

Brady G, MacArthur GJ, Farrell PJ, 2008, Epstein-Barr virus and Burkitt lymphoma, POSTGRADUATE MEDICAL JOURNAL, Vol: 84, Pages: 372-377, ISSN: 0032-5473

Journal article

Brady G, MacArthur GJ, Farrell PJ, 2007, Epstein-Barr virus and Burkitt lymphoma, JOURNAL OF CLINICAL PATHOLOGY, Vol: 60, Pages: 1397-1402, ISSN: 0021-9746

Journal article

Farrell PJ, 2007, Role for HLA in susceptibility to infectious mononucleosis, JOURNAL OF CLINICAL INVESTIGATION, Vol: 117, Pages: 2756-2758, ISSN: 0021-9738

Journal article

Pattle SB, Farrell PJ, 2006, The role of Epstein-Barr virus in cancer, EXPERT OPINION ON BIOLOGICAL THERAPY, Vol: 6, Pages: 1193-1205, ISSN: 1471-2598

Journal article

Spender LC, Lucchesi W, Bodelon G, Bilancio A, Karstegl CE, Asano T, Dittrich-Breiholz O, Kracht M, Vanhaesebroeck B, Farrell PJet al., 2006, Cell target genes of Epstein-Barr virus transcription factor EBNA-2: induction of the p55 alpha regulatory subunit of PI3-kinase and its role in survival of EREB2.5 cells, JOURNAL OF GENERAL VIROLOGY, Vol: 87, Pages: 2859-2867, ISSN: 0022-1317

Journal article

Amon W, White RE, Farrell PJ, 2006, Epstein-Barr virus origin of lytic replication mediates association of replicating episomes with promyelocytic leukaemia protein nuclear bodies and replication compartments, JOURNAL OF GENERAL VIROLOGY, Vol: 87, Pages: 1133-1137, ISSN: 0022-1317

Journal article

Whiteman HJ, Farrell PJ, 2006, RUNX expression and function in human B cells, CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION, Vol: 16, Pages: 31-44, ISSN: 1045-4403

Journal article

Syed N, Smith P, Sullivan A, Spender LC, Dyer M, Karran L, O'Nions J, Allday M, Hoffmann I, Crawford D, Griffin B, Farrell PJ, Crook Tet al., 2006, Transcriptional silencing of Polo-like kinase 2 (SNK/PLK2) is a frequent event in B-cell malignancies, BLOOD, Vol: 107, Pages: 250-256, ISSN: 0006-4971

Journal article

Amon W, Farrell PJ, 2005, Reactivation of Epstein-Barr virus from latency, REVIEWS IN MEDICAL VIROLOGY, Vol: 15, Pages: 149-156, ISSN: 1052-9276

Journal article

Spender LC, Whiteman HJ, Karstegl CE, Farrell PJet al., 2005, Transcriptional cross-regulation of RUNX1 by RUNX3 in human B cells, ONCOGENE, Vol: 24, Pages: 1873-1881, ISSN: 0950-9232

Journal article

Farrell PJ, 2005, Can plasma Epstein-Barr virus DNA levels be used to monitor nasopharyngeal carcinoma progression?, NATURE CLINICAL PRACTICE ONCOLOGY, Vol: 2, Pages: 14-15, ISSN: 1743-4254

Journal article

Amon W, Binne UK, Bryant H, Jenkins PJ, Karstegl CE, Farrell PJet al., 2004, Lytic cycle gene regulation of Epstein-Barr virus, JOURNAL OF VIROLOGY, Vol: 78, Pages: 13460-13469, ISSN: 0022-538X

Journal article

Sullivan A, Syed N, Gasco M, Bergamaschi D, Trigiante G, Attard M, Hiller L, Farrell PJ, Smith P, Lu X, Crook Tet al., 2004, Polymorphism in wild-type p53 modulates response to chemotherapy in vitro and in vivo., Oncogene, Vol: 23, Pages: 3328-3337

Journal article

de Jesus O, Smith PR, Spender LC, Karstegl CE, Niller HH, Huang D, Farrell PJet al., 2003, Updated Epstein-Barr virus (EBV) DNA sequence and analysis of a promoter for the BART (CST, BARF0) RNAs of EBV, JOURNAL OF GENERAL VIROLOGY, Vol: 84, Pages: 1443-1450, ISSN: 0022-1317

Journal article

Bergamaschi D, Gasco M, Hiller L, Sullivan A, Syed N, Trigiante G, Yulug I, Merlano M, Numico G, Comino A, Attard M, Reelfs O, Gusterson B, Bell AK, Heath V, Tavassoli M, Farrell PJ, Smith P, Lu X, Crook Tet al., 2003, p53 polymorphism influences response in cancer chemotherapy via modulation of p73-dependent apoptosis, CANCER CELL, Vol: 3, Pages: 387-402, ISSN: 1535-6108

Journal article

Binne UK, Amon W, Farrell PJ, 2002, Promoter sequences required for reactivation of Epstein-Barr virus from latency, JOURNAL OF VIROLOGY, Vol: 76, Pages: 10282-10289, ISSN: 0022-538X

Journal article

Bryant H, Farrell PJ, 2002, Signal transduction and transcription factor modification during reactivation of Epstein-Barr virus from latency, JOURNAL OF VIROLOGY, Vol: 76, Pages: 10290-10298, ISSN: 0022-538X

Journal article

Farrell PJ, 2002, Tumour viruses - could they be an Achilles' heel of cancer?, EUROPEAN JOURNAL OF CANCER, Vol: 38, Pages: 1815-1816, ISSN: 0959-8049

Journal article

Farrell PJ, 2002, Cell-switching and kissing, NATURE MEDICINE, Vol: 8, Pages: 559-560, ISSN: 1078-8956

Journal article

Spender LC, Cornish GH, Sullivan A, Farrell PJet al., 2002, Expression of transcription factor AML-2 (RUNX3, CBF alpha-3) is induced by Epstein-Barr virus EBNA-2 and correlates with the B-cell activation phenotype, JOURNAL OF VIROLOGY, Vol: 76, Pages: 4919-4927, ISSN: 0022-538X

Journal article

Gasco M, Bell AK, Heath V, Sullivan A, Smith P, Hiller L, Yulug I, Numico G, Merlano M, Farrell PJ, Tavassoli M, Gusterson B, Crook Tet al., 2002, Epigenetic inactivation of 14-3-3 sigma in oral carcinoma: Association with p16(INK4a) silencing and human papillomavirus negativity, CANCER RESEARCH, Vol: 62, Pages: 2072-2076, ISSN: 0008-5472

Journal article

Gasco M, Sullivan A, Repellin C, Brooks L, Farrell PJ, Tidy JA, Dunne B, Gusterson B, Evans DJ, Crook Tet al., 2002, Coincident inactivation of 14-3-3 sigma and p16(INK4a) is an early event in vulval squamous neoplasia, ONCOGENE, Vol: 21, Pages: 1876-1881, ISSN: 0950-9232

Journal article

Reddy A, Yuille M, Sullivan A, Repellin C, Bell A, Tidy JA, Evans DJ, Farrell PJ, Gusterson B, Gasco M, Crook Tet al., 2002, Analysis of CHK2 in vulval neoplasia, BRITISH JOURNAL OF CANCER, Vol: 86, Pages: 756-760, ISSN: 0007-0920

Journal article

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