Imperial College London

ProfessorPaulFarrell

Faculty of MedicineDepartment of Infectious Disease

Professor of Tumour Virology
 
 
 
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Contact

 

+44 (0)20 7594 2005p.farrell Website

 
 
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Location

 

Section of VirologyNorfolk PlaceSt Mary's Campus

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Summary

 

Publications

Publication Type
Year
to

155 results found

Sullivan A, Yuille M, Repellin C, Reddy A, Reelfs O, Bell A, Dunne B, Gusterson BA, Osin P, Farrell PJ, Yulug I, Evans A, Ozcelik T, Gasco M, Crook Tet al., 2002, Concomitant inactivation of p53 and Chk2 in breast cancer, ONCOGENE, Vol: 21, Pages: 1316-1324, ISSN: 0950-9232

Journal article

Brooks LA, Sullivan A, O'Nions J, Bell A, Dunne B, Tidy JA, Evans DJ, Osin P, Vousden KH, Gusterson B, Farrell PJ, Storey A, Gasco M, Sakai T, Crook Tet al., 2002, E7 proteins from oncogenic human papillomavirus types transactivate p73: role in cervical intraepithelial neoplasia., Br J Cancer, Vol: 86, Pages: 263-268, ISSN: 0007-0920

In common with other E2F1 responsive genes such as p14(ARF) and B-myb, the promoter of p73 is shown to be positively regulated in cell lines and primary human keratinocytes by E7 proteins from oncogenic human papillomavirus (HPV) types 16, 18, 31 and 33, but not HPV 6. Mutational analysis revealed that transactivation of the p73 promoter by HPV 16E7 requires association with pRb. Expression of p73 in normal cervical epithelium is confined to the basal and supra-basal layers. In contrast, expression in neoplastic lesions is detected throughout the epithelium and increases with grade of neoplasia, being maximal in squamous cell cancers (SCC). Deregulation of expression of the N-terminal splice variant p73Delta2 was observed in a significant proportion of cancers, but not in normal epithelium. The frequent over-expression of p73Delta2, which has recognized transdominant properties, in malignant and pre-malignant lesions suggests a role in the oncogenic process in cervical epithelium.

Journal article

Brooks LA, Sullivan A, O'Nions J, Bell A, Dunne B, Tidy JA, Evans DJ, Osin P, Vousden KH, Gusterson B, Farrell PJ, Storey A, Gasco M, Sakai T, Crook Tet al., 2002, E7 proteins from oncogenic human papillomavirus types transactivate p73: role in cervical intraepithelial neoplasia, BRITISH JOURNAL OF CANCER, Vol: 86, Pages: 263-268, ISSN: 0007-0920

Journal article

Mundodi V, Somanna A, Farrell PJ, Gedamu Let al., 2002, Genomic organization and functional expression of differentially regulated cysteine protease genes of Leishmania donovani complex, GENE, Vol: 282, Pages: 257-265, ISSN: 0378-1119

Journal article

O'Nions J, Brooks LA, Sullivan A, Bell A, Dunne B, Rozycka M, Reddy A, Tidy JA, Evans D, Farrell PJ, Evans A, Gasco M, Gusterson B, Crook Tet al., 2001, p73 is over-expressed in vulval cancer principally as the Delta 2 isoform, BRITISH JOURNAL OF CANCER, Vol: 85, Pages: 1551-1556, ISSN: 0007-0920

Journal article

Wensing B, Stuhler A, Jenkins P, Hollyoake M, Karstegl CE, Farrell PJet al., 2001, Variant chromatin structure of the oriP region of Epstein-Barr virus and regulation of EBER1 expression by upstream sequences and oriP, JOURNAL OF VIROLOGY, Vol: 75, Pages: 6235-6241, ISSN: 0022-538X

Journal article

Spender LC, Cornish GH, Rowland B, Kempkes B, Farrell PJet al., 2001, Direct and indirect regulation of cytokine and cell cycle proteins by EBNA-2 during Epstein-Barr virus infection, JOURNAL OF VIROLOGY, Vol: 75, Pages: 3537-3546, ISSN: 0022-538X

Journal article

Inman GJ, Binne UK, Parker GA, Farrell PJ, Allday MJet al., 2001, Activators of the Epstein-Barr virus lytic program concomitantly induce apoptosis, but lytic gene expression protects from cell death, JOURNAL OF VIROLOGY, Vol: 75, Pages: 2400-2410, ISSN: 0022-538X

Journal article

Farrell PJ, 2001, Epstein-Barr virus. The B95-8 strain map., Methods Mol Biol, Vol: 174, Pages: 3-12, ISSN: 1064-3745

Journal article

Sashegyi AI, Brown KS, Farrell PJ, 2000, Application of a generalized random effects regression model for cluster-correlated longitudinal data to a school-based smoking prevention trial, AMERICAN JOURNAL OF EPIDEMIOLOGY, Vol: 152, Pages: 1192-1200, ISSN: 0002-9262

Journal article

Brooks LA, Tidy JA, Gusterson B, Hiller L, O'Nions J, Gasco M, Marin MC, Farrell PJ, Kaelin WG, Crook Tet al., 2000, Preferential retention of codon 72 arginine p53 in squamous cell carcinomas of the vulva occurs in cancers positive and negative for human papillomavirus, CANCER RESEARCH, Vol: 60, Pages: 6875-6877, ISSN: 0008-5472

Journal article

Smith PR, de Jesus O, Turner D, Hollyoake M, Karstegl CE, Griffin BE, Karran L, Wang YL, Hayward SD, Farrell PJet al., 2000, Structure and coding content of CST (BART) family RNAs of Epstein-Barr virus, JOURNAL OF VIROLOGY, Vol: 74, Pages: 3082-3092, ISSN: 0022-538X

Journal article

Wensing B, Farrell PJ, 2000, Regulation of cell growth and death by Epstein-Barr virus, MICROBES AND INFECTION, Vol: 2, Pages: 77-84, ISSN: 1286-4579

Journal article

Jenkins PJ, Binne UK, Farrell PJ, 2000, Histone acetylation and reactivation of Epstein-Barr virus from latency, JOURNAL OF VIROLOGY, Vol: 74, Pages: 710-720, ISSN: 0022-538X

Journal article

Kiermaier A, Gawn JM, Desbarats L, Saffrich R, Ansorge W, Farrell PJ, Eilers M, Packham Get al., 1999, DNA binding of USF is required for specific E-box dependent gene activation in vivo, ONCOGENE, Vol: 18, Pages: 7200-7211, ISSN: 0950-9232

Journal article

Spender LC, Cannell EJ, Hollyoake M, Wensing B, Gawn JM, Brimmell M, Packham G, Farrell PJet al., 1999, Control of cell cycle entry and apoptosis in B lymphocytes infected by Epstein-Barr virus, JOURNAL OF VIROLOGY, Vol: 73, Pages: 4678-4688, ISSN: 0022-538X

Journal article

Cannell EJ, Farrell PJ, Sinclair AJ, 1998, Cell cycle arrest following exposure of EBV-immortalised B-cells to gamma irradiation correlates with inhibition of cdk2 activity, FEBS LETTERS, Vol: 439, Pages: 297-301, ISSN: 0014-5793

Journal article

Farrell PJ, 1998, Signal transduction from the Epstein-Barr virus LMP-1 transforming protein, TRENDS IN MICROBIOLOGY, Vol: 6, Pages: 175-177, ISSN: 0966-842X

Journal article

Cludts I, Farrell PJ, 1998, Multiple functions within the Epstein-Barr virus EBNA-3A protein, JOURNAL OF VIROLOGY, Vol: 72, Pages: 1862-1869, ISSN: 0022-538X

Journal article

Radkov SA, Bain M, Farrell PJ, West M, Rowe M, Allday MJet al., 1997, Epstein-Barr virus EBNA3C represses Cp, the major promoter for EBNA expression, but has no effect on the promoter of the cell gene CD21, JOURNAL OF VIROLOGY, Vol: 71, Pages: 8552-8562, ISSN: 0022-538X

Journal article

Wangoo A, Shaw RJ, Diss TC, Farrell PJ, duBois RM, Nicholson AGet al., 1997, Cryptogenic fibrosing alveolitis: lack of association with Epstein-Barr virus infection, THORAX, Vol: 52, Pages: 888-891, ISSN: 0040-6376

Journal article

Farrell PJ, Hollyoake M, Niedobitek G, Agathanggelou A, Morgan A, Wedderburn Net al., 1997, Direct demonstration of persistent Epstein-Barr virus gene expression in peripheral blood of infected common marmosets and analysis of virus-infected tissues in vivo, JOURNAL OF GENERAL VIROLOGY, Vol: 78, Pages: 1417-1424, ISSN: 0022-1317

Journal article

Evans TJ, Brooks L, Farrell PJ, 1997, A strategy for specific targeting of therapeutic agents to tumour cells of virus-associated cancers, GENE THERAPY, Vol: 4, Pages: 264-267, ISSN: 0969-7128

Journal article

Farrell PJ, Cludts I, Stuhler A, 1997, Epstein-Barr virus genes and cancer cells, BIOMEDICINE & PHARMACOTHERAPY, Vol: 51, Pages: 258-267, ISSN: 0753-3322

Journal article

Parker GA, Crook T, Bain M, Sara EA, Farrell PJ, Allday MJet al., 1996, Epstein-Barr virus nuclear antigen (EBNA)3C is an immortalizing oncoprotein with similar properties to adenovirus EIA and papillomavirus E7, ONCOGENE, Vol: 13, Pages: 2541-2549, ISSN: 0950-9232

Journal article

Cannell EJ, Farrell PJ, Sinclair AJ, 1996, Epstein-Barr virus exploits the normal cell pathway to regulate Rb activity during the immortalisation of primary B-cells, ONCOGENE, Vol: 13, Pages: 1413-1421, ISSN: 0950-9232

Journal article

Jenkins PJ, Farrell PJ, 1996, Are particular Epstein-Barr virus strains linked to disease?, SEMINARS IN CANCER BIOLOGY, Vol: 7, Pages: 209-215, ISSN: 1044-579X

Journal article

Bain M, Watson RJ, Farrell PJ, Allday MJet al., 1996, Epstein-Barr virus nuclear antigen 3C is a powerful repressor of transcription when tethered to DNA, JOURNAL OF VIROLOGY, Vol: 70, Pages: 2481-2489, ISSN: 0022-538X

Journal article

Evans TJ, Farrell PJ, Swaminathan S, 1996, Molecular genetic analysis of Epstein-Barr virus Cp promoter function, JOURNAL OF VIROLOGY, Vol: 70, Pages: 1695-1705, ISSN: 0022-538X

Journal article

ALLDAY MJ, INMAN GJ, CRAWFORD DH, FARRELL PJet al., 1995, DNA-DAMAGE IN HUMAN B-CELLS CAN INDUCE APOPTOSIS, PROCEEDING FROM G(1)/S WHEN P53 IS TRANSACTIVATION COMPETENT AND G(2)/M WHEN IT IS TRANSACTIVATION DEFECTIVE, EMBO JOURNAL, Vol: 14, Pages: 4994-5005, ISSN: 0261-4189

Journal article

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