Imperial College London

ProfessorPaulFarrell

Faculty of MedicineDepartment of Infectious Disease

Professor of Tumour Virology
 
 
 
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Contact

 

+44 (0)20 7594 2005p.farrell Website

 
 
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Location

 

Section of VirologyNorfolk PlaceSt Mary's Campus

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Summary

 

Publications

Publication Type
Year
to

155 results found

LAUX G, ECONOMOU A, FARRELL PJ, 1989, THE TERMINAL PROTEIN GENE-2 OF EPSTEIN-BARR VIRUS IS TRANSCRIBED FROM A BIDIRECTIONAL LATENT PROMOTER REGION, JOURNAL OF GENERAL VIROLOGY, Vol: 70, Pages: 3079-3084, ISSN: 0022-1317

Journal article

TIDY JA, MASON WP, FARRELL PJ, 1989, A NEW AND SENSITIVE METHOD OF SCREENING FOR HUMAN PAPILLOMAVIRUS INFECTION, OBSTETRICS AND GYNECOLOGY, Vol: 74, Pages: 410-414, ISSN: 0029-7844

Journal article

ROONEY CM, ROWE DT, RAGOT T, FARRELL PJet al., 1989, THE SPLICED BZLF1 GENE OF EPSTEIN-BARR VIRUS (EBV) TRANSACTIVATES AN EARLY EBV PROMOTER AND INDUCES THE VIRUS PRODUCTIVE CYCLE, JOURNAL OF VIROLOGY, Vol: 63, Pages: 3109-3116, ISSN: 0022-538X

Journal article

TIDY JA, VOUSDEN KH, FARRELL PJ, 1989, RELATION BETWEEN INFECTION WITH A SUBTYPE OF HPV16 AND CERVICAL NEOPLASIA, LANCET, Vol: 1, Pages: 1225-1227, ISSN: 0140-6736

Journal article

CUNNINGHAM D, HICKISH T, ROSIN RD, SAUVEN P, BARON JH, FARRELL PJ, ISAACSON Pet al., 1989, POLYMERASE CHAIN-REACTION FOR DETECTION OF DISSEMINATION IN GASTRIC LYMPHOMA, LANCET, Vol: 1, Pages: 695-697, ISSN: 0140-6736

Journal article

TIDY J, VOUSDEN KH, MASON P, FARRELL PJet al., 1989, A NOVEL DELETION WITHIN THE UPSTREAM REGULATORY REGION OF EPISOMAL HUMAN PAPILLOMAVIRUS TYPE-16, JOURNAL OF GENERAL VIROLOGY, Vol: 70, Pages: 999-1004, ISSN: 0022-1317

Journal article

TIDY JA, PARRY GCN, WARD P, COLEMAN DV, PETO J, MALCOLM ADB, FARRELL PJet al., 1989, HIGH-RATE OF HUMAN PAPILLOMAVIRUS TYPE-16 INFECTION IN CYTOLOGICALLY NORMAL CERVICES, LANCET, Vol: 1, Pages: 434-434, ISSN: 0140-6736

Journal article

FARRELL PJ, ROWE DT, ROONEY CM, KOUZARIDES Tet al., 1989, EPSTEIN-BARR VIRUS BZLF1 TRANS-ACTIVATOR SPECIFICALLY BINDS TO A CONSENSUS AP-1 SITE AND IS RELATED TO C-FOS, EMBO JOURNAL, Vol: 8, Pages: 127-132, ISSN: 0261-4189

Journal article

HATFULL G, BANKIER AT, BARRELL BG, FARRELL PJet al., 1988, SEQUENCE-ANALYSIS OF RAJI EPSTEIN-BARR VIRUS-DNA, VIROLOGY, Vol: 164, Pages: 334-340, ISSN: 0042-6822

Journal article

LAUX G, PERRICAUDET M, FARRELL PJ, 1988, A SPLICED EPSTEIN-BARR VIRUS GENE EXPRESSED IN IMMORTALIZED LYMPHOCYTES IS CREATED BY CIRCULARIZATION OF THE LINEAR VIRAL GENOME, EMBO JOURNAL, Vol: 7, Pages: 769-774, ISSN: 0261-4189

Journal article

BODESCOT M, PERRICAUDET M, FARRELL PJ, 1987, A PROMOTER FOR THE HIGHLY SPLICED EBNA FAMILY OF RNAS OF EPSTEIN-BARR-VIRUS, JOURNAL OF VIROLOGY, Vol: 61, Pages: 3424-3430, ISSN: 0022-538X

Journal article

JOAB I, ROWE DT, BODESCOT M, NICOLAS JC, FARRELL PJ, PERRICAUDET Met al., 1987, MAPPING OF THE GENE CODING FOR EPSTEIN-BARR VIRUS-DETERMINED NUCLEAR ANTIGEN EBNA3 AND ITS TRANSIENT OVEREXPRESSION IN A HUMAN CELL-LINE BY USING AN ADENOVIRUS EXPRESSION VECTOR, JOURNAL OF VIROLOGY, Vol: 61, Pages: 3340-3344, ISSN: 0022-538X

Journal article

ROWE M, ROWE DT, GREGORY CD, YOUNG LS, FARRELL PJ, RUPANI H, RICKINSON ABet al., 1987, DIFFERENCES IN B-CELL GROWTH PHENOTYPE REFLECT NOVEL PATTERNS OF EPSTEIN-BARR-VIRUS LATENT GENE-EXPRESSION IN BURKITT-LYMPHOMA CELLS, EMBO JOURNAL, Vol: 6, Pages: 2743-2751, ISSN: 0261-4189

Journal article

JENSON HB, FARRELL PJ, MILLER G, 1987, SEQUENCES OF THE EPSTEIN-BARR-VIRUS (EBV) LARGE INTERNAL REPEAT FORM THE CENTER OF A 16-KILOBASE-PAIR PALINDROME OF EBV (P3HR-1) HETEROGENEOUS DNA, JOURNAL OF VIROLOGY, Vol: 61, Pages: 1495-1506, ISSN: 0022-538X

Journal article

ROWE DT, FARRELL PJ, MILLER G, 1987, NOVEL NUCLEAR ANTIGENS RECOGNIZED BY HUMAN-SERA IN LYMPHOCYTES LATENTLY INFECTED BY EPSTEIN-BARR-VIRUS, VIROLOGY, Vol: 156, Pages: 153-162, ISSN: 0042-6822

Journal article

ROWE DT, ROWE M, EVAN GI, WALLACE LE, FARRELL PJ, RICKINSON ABet al., 1986, RESTRICTED EXPRESSION OF EBV LATENT GENES AND LYMPHOCYTE-T-DETECTED MEMBRANE ANTIGEN IN BURKITTS-LYMPHOMA CELLS, EMBO JOURNAL, Vol: 5, Pages: 2599-2607, ISSN: 0261-4189

Journal article

GIBSON TJ, BARRELL BG, FARRELL PJ, 1986, CODING CONTENT AND EXPRESSION OF THE EBV B95-8 GENOME IN THE REGION FROM BASE 62,248 TO BASE 82,920, VIROLOGY, Vol: 152, Pages: 136-148, ISSN: 0042-6822

Journal article

SCHOLL SM, PILLERS EMK, ROBINSON RE, FARRELL PJet al., 1985, PREVALENCE OF HUMAN PAPILLOMAVIRUS TYPE-16 DNA IN CERVICAL-CARCINOMA SAMPLES IN EAST-ANGLIA, INTERNATIONAL JOURNAL OF CANCER, Vol: 35, Pages: 215-218, ISSN: 0020-7136

Journal article

HUDSON GS, FARRELL PJ, BARRELL BG, 1985, 2 RELATED BUT DIFFERENTIALLY EXPRESSED POTENTIAL MEMBRANE-PROTEINS ENCODED BY THE ECORI DHET REGION OF EPSTEIN-BARR VIRUS-B95-8, JOURNAL OF VIROLOGY, Vol: 53, Pages: 528-535, ISSN: 0022-538X

Journal article

DYSON PJ, FARRELL PJ, 1985, CHROMATIN STRUCTURE OF EPSTEIN-BARR VIRUS, JOURNAL OF GENERAL VIROLOGY, Vol: 66, Pages: 1931-1940, ISSN: 0022-1317

Journal article

BIGGIN M, FARRELL PJ, BARRELL BG, 1984, TRANSCRIPTION AND DNA-SEQUENCE OF THE BAMHI L-FRAGMENT OF B95-8 EPSTEIN-BARR VIRUS, EMBO JOURNAL, Vol: 3, Pages: 1083-1090, ISSN: 0261-4189

Journal article

BAER R, BANKIER AT, BIGGIN MD, DEININGER PL, FARRELL PJ, GIBSON TJ, HATFULL G, HUDSON GS, SATCHWELL SC, SEGUIN C, TUFFNELL PS, BARRELL BGet al., 1984, DNA-SEQUENCE AND EXPRESSION OF THE B95-8 EPSTEIN-BARR VIRUS GENOME, NATURE, Vol: 310, Pages: 207-211, ISSN: 0028-0836

Journal article

Bankier AT, Deininger PL, Satchwell SC, Baer R, Farrell PJ, Barrell BGet al., 1983, DNA sequence analysis of the EcoRI Dhet fragment of B95-8 Epstein-Barr virus containing the terminal repeat sequences., Mol Biol Med, Vol: 1, Pages: 425-445, ISSN: 0735-1313

An analysis of the approximately 12,440 base-pair sequence of the EcoRI Dhet fragment isolated from the circular episomal form of the B95-8 strain of Epstein-Barr virus is presented. This fragment contains the covalently joined ends of the intracellular episomal form of the molecule. In the viral capsid the DNA is linear and the joining is mediated via the terminal repeated DNA. Four copies of tandem repeated DNA were present in this clone, three with a repeat size of 538 and one of 523. The positions of a number of possible protein coding regions and transcription signals are discussed. In particular a possible spliced coding region for an approximately 45,000 Mr protein expressed in latently infected transformed cells is proposed. The predicted protein sequence contains hydrophobic regions separated by charged amino acids reminiscent of a membrane protein.

Journal article

S├ęguin C, Farrell PJ, Barrell BG, 1983, DNA sequence and transcription of the BamHI fragment B region of B95-8 Epstein-Barr virus., Mol Biol Med, Vol: 1, Pages: 369-392, ISSN: 0735-1313

The DNA sequence of the BamHI fragments B and the contiguous portion of G extending from the BamHI site to the EcoRI site of the B95-8 strain of Epstein-Barr virus has been determined. The sequence has been analysed for possible protein coding regions and transcriptional control sites. At least eight large open reading frames were found. Several RNA polymerase II promoters have been identified in the BamHI-B fragments. RNAs transcribed from these promoters are substantially induced by treatment of B95-8 cells with 12-O-tetradecanoylphorbol-13-acetate. Phosphonoacetic acid reversed the stimulatory effect of 12-O-tetradecanoylphorbol-13-acetate on the transcription of these RNAs indicating that they are late RNAs.

Journal article

Bankier AT, Deininger PL, Farrell PJ, Barrell BGet al., 1983, Sequence analysis of the 17,166 base-pair EcoRI fragment C of B95-8 Epstein-Barr virus., Mol Biol Med, Vol: 1, Pages: 21-45, ISSN: 0735-1313

In order to provide a framework for understanding the molecular biology of Epstein-Barr virus (EBV), we are determining the DNA sequence of the virus and studying the organization of genes on the viral genome. In this paper we report the DNA sequence of the EcoRI C fragment of the B95-8 strain of EBV. The large (approximately 13.6 kb) deletion in this strain has been located by comparison with the DNA sequence of EBV isolated from Raji cells. The sequence has been analysed for possible protein coding regions and transcriptional control sites. At least eight large open reading frames are found, some of them associated with canonical promoter and polyadenylation sequences. The sequences of some of the encoded proteins suggest that they are membrane proteins. It is known that antibodies to major membrane glycoproteins of EBV can neutralize infection in tissue culture. A possible relationship between some of the encoded proteins and the major membrane glycoproteins of the virus is discussed.

Journal article

FARRELL PJ, BANKIER A, SEGUIN C, DEININGER P, BARRELL BGet al., 1983, LATENT AND LYTIC CYCLE PROMOTERS OF EPSTEIN-BARR VIRUS, EMBO JOURNAL, Vol: 2, Pages: 1331-1338, ISSN: 0261-4189

Journal article

FARRELL PJ, DEININGER PL, BANKIER A, BARRELL Bet al., 1983, HOMOLOGOUS UPSTREAM SEQUENCES NEAR EPSTEIN-BARR VIRUS PROMOTERS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, Vol: 80, Pages: 1565-1569, ISSN: 0027-8424

Journal article

DOUGHERTY JP, SAMANTA H, FARRELL PJ, LENGYEL Pet al., 1980, INTERFERON, DOUBLE-STRANDED-RNA, AND RNA DEGRADATION - ISOLATION OF HOMOGENEOUS PPPA(2'P5'A)N-1 SYNTHETASE FROM EHRLICH ASCITES TUMOR-CELLS, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 255, Pages: 3813-3816, ISSN: 0021-9258

Journal article

FARRELL PJ, BROEZE RJ, LENGYEL P, 1979, ACCUMULATION OF AN MESSENGER-RNA AND PROTEIN IN INTERFERON-TREATED EHRLICH ASCITES TUMOR-CELLS, NATURE, Vol: 279, Pages: 523-525, ISSN: 0028-0836

Journal article

FARRELL PJ, HUNT T, JACKSON RJ, 1978, ANALYSIS OF PHOSPHORYLATION OF PROTEIN-SYNTHESIS INITIATION-FACTOR EIF-2 BY 2-DIMENSIONAL GEL-ELECTROPHORESIS, EUROPEAN JOURNAL OF BIOCHEMISTRY, Vol: 89, Pages: 517-521, ISSN: 0014-2956

Journal article

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