Imperial College London

ProfessorPaulFarrell

Faculty of MedicineDepartment of Infectious Disease

Professor of Tumour Virology
 
 
 
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Contact

 

+44 (0)20 7594 2005p.farrell Website

 
 
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Location

 

Section of VirologyNorfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Farrell,
author = {Farrell, PJ},
journal = {Annual Review of Pathology: Mechanisms of Disease},
title = {EpsteinBarr virus and cancer},
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - EpsteinBarr virus (EBV) contributes to about 1.5% of all cases of human cancer worldwide and viral genes are expressed in the malignant cells. EBV also very efficiently causes proliferation of infected human B lymphocytes. The functions of the viral proteins and small RNAs that may contribute to the EBV associated cancers are becoming increasingly clear and a broader understanding of sequence variation of the virus genome has helped to interpret their roles. The improved understanding of the mechanisms of these cancers means that the EBV associated cancers offer great opportunities for early diagnosis of treatable stages of disease and immunotherapy to target EBV infected cells or overcome immune evasion. There is also scope for prevention of disease by immunisation and for development of therapeutic agents that target EBV gene products expressed in the cancers.
AU - Farrell,PJ
SN - 1553-4014
TI - EpsteinBarr virus and cancer
T2 - Annual Review of Pathology: Mechanisms of Disease
ER -