Publications
164 results found
de Jesus O, Smith PR, Spender LC, et al., 2003, Updated Epstein-Barr virus (EBV) DNA sequence and analysis of a promoter for the BART (CST, BARF0) RNAs of EBV, JOURNAL OF GENERAL VIROLOGY, Vol: 84, Pages: 1443-1450, ISSN: 0022-1317
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- Citations: 89
Bergamaschi D, Gasco M, Hiller L, et al., 2003, p53 polymorphism influences response in cancer chemotherapy via modulation of p73-dependent apoptosis, CANCER CELL, Vol: 3, Pages: 387-402, ISSN: 1535-6108
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- Citations: 372
Bryant H, Farrell PJ, 2002, Signal transduction and transcription factor modification during reactivation of Epstein-Barr virus from latency, JOURNAL OF VIROLOGY, Vol: 76, Pages: 10290-10298, ISSN: 0022-538X
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- Citations: 60
Binné UK, Amon W, Farrell PJ, 2002, Promoter sequences required for reactivation of Epstein-Barr virus from latency, JOURNAL OF VIROLOGY, Vol: 76, Pages: 10282-10289, ISSN: 0022-538X
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- Citations: 38
Farrell PJ, 2002, Tumour viruses - could they be an Achilles' heel of cancer?, EUROPEAN JOURNAL OF CANCER, Vol: 38, Pages: 1815-1816, ISSN: 0959-8049
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- Citations: 13
Farrell PJ, 2002, Cell-switching and kissing, NATURE MEDICINE, Vol: 8, Pages: 559-560, ISSN: 1078-8956
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- Citations: 1
Spender LC, Cornish GH, Sullivan A, et al., 2002, Expression of transcription factor AML-2 (RUNX3, CBFα-3) is induced by Epstein-Barr virus EBNA-2 and correlates with the B-cell activation phenotype, JOURNAL OF VIROLOGY, Vol: 76, Pages: 4919-4927, ISSN: 0022-538X
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- Citations: 67
Gasco M, Bell AK, Heath V, et al., 2002, Epigenetic inactivation of 14-3-3 σ in oral carcinoma:: Association with p16<SUP>INK4a</SUP> silencing and human papillomavirus negativity, CANCER RESEARCH, Vol: 62, Pages: 2072-2076, ISSN: 0008-5472
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- Citations: 106
Gasco M, Sullivan A, Repellin C, et al., 2002, Coincident inactivation of 14-3-3σ and p16<SUP>INK4a</SUP> is an early event in vulval squamous neoplasia, ONCOGENE, Vol: 21, Pages: 1876-1881, ISSN: 0950-9232
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- Citations: 86
Reddy A, Yuille M, Sullivan A, et al., 2002, Analysis of CHK2 in vulval neoplasia, BRITISH JOURNAL OF CANCER, Vol: 86, Pages: 756-760, ISSN: 0007-0920
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- Citations: 28
Sullivan A, Yuille M, Repellin C, et al., 2002, Concomitant inactivation of p53 and Chk2 in breast cancer, ONCOGENE, Vol: 21, Pages: 1316-1324, ISSN: 0950-9232
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- Citations: 68
Brooks LA, Sullivan A, O'Nions J, et al., 2002, E7 proteins from oncogenic human papillomavirus types transactivate p73: role in cervical intraepithelial neoplasia, BRITISH JOURNAL OF CANCER, Vol: 86, Pages: 263-268, ISSN: 0007-0920
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- Citations: 29
Brooks LA, Sullivan A, O'Nions J, et al., 2002, E7 proteins from oncogenic human papillomavirus types transactivate p73: role in cervical intraepithelial neoplasia., Br J Cancer, Vol: 86, Pages: 263-268, ISSN: 0007-0920
In common with other E2F1 responsive genes such as p14(ARF) and B-myb, the promoter of p73 is shown to be positively regulated in cell lines and primary human keratinocytes by E7 proteins from oncogenic human papillomavirus (HPV) types 16, 18, 31 and 33, but not HPV 6. Mutational analysis revealed that transactivation of the p73 promoter by HPV 16E7 requires association with pRb. Expression of p73 in normal cervical epithelium is confined to the basal and supra-basal layers. In contrast, expression in neoplastic lesions is detected throughout the epithelium and increases with grade of neoplasia, being maximal in squamous cell cancers (SCC). Deregulation of expression of the N-terminal splice variant p73Delta2 was observed in a significant proportion of cancers, but not in normal epithelium. The frequent over-expression of p73Delta2, which has recognized transdominant properties, in malignant and pre-malignant lesions suggests a role in the oncogenic process in cervical epithelium.
Mundodi V, Somanna A, Farrell PJ, et al., 2002, Genomic organization and functional expression of differentially regulated <i>cysteine protease</i> genes of <i>Leishmania donovani</i> complex, GENE, Vol: 282, Pages: 257-265, ISSN: 0378-1119
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- Citations: 42
O'Nions J, Brooks LA, Sullivan A, et al., 2001, p73 is over-expressed in vulval cancer principally as the Δ2 isoform, BRITISH JOURNAL OF CANCER, Vol: 85, Pages: 1551-1556, ISSN: 0007-0920
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- Citations: 41
Wensing B, Stühler A, Jenkins P, et al., 2001, Variant chromatin structure of the <i>oriP</i> region of Epstein-Barr virus and regulation of EBER1 expression by upstream sequences and <i>oriP</i>, JOURNAL OF VIROLOGY, Vol: 75, Pages: 6235-6241, ISSN: 0022-538X
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- Citations: 26
Spender LC, Cornish GH, Rowland B, et al., 2001, Direct and indirect regulation of cytokine and cell cycle proteins by EBNA-2 during Epstein-Barr virus infection, JOURNAL OF VIROLOGY, Vol: 75, Pages: 3537-3546, ISSN: 0022-538X
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- Citations: 47
Inman GJ, Binné UK, Parker GA, et al., 2001, Activators of the Epstein-Barr virus lytic program concomitantly induce apoptosis, but lytic gene expression protects from cell death, JOURNAL OF VIROLOGY, Vol: 75, Pages: 2400-2410, ISSN: 0022-538X
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- Citations: 54
Farrell PJ, 2001, Epstein-Barr virus. The B95-8 strain map., Methods Mol Biol, Vol: 174, Pages: 3-12, ISSN: 1064-3745
Sashegyi AI, Brown KS, Farrell PJ, 2000, Application of a generalized random effects regression model for cluster-correlated longitudinal data to a school-based smoking prevention trial, AMERICAN JOURNAL OF EPIDEMIOLOGY, Vol: 152, Pages: 1192-1200, ISSN: 0002-9262
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- Citations: 23
Brooks LA, Tidy JA, Gusterson B, et al., 2000, Preferential retention of codon 72 arginine p53 in squamous cell carcinomas of the vulva occurs in cancers positive and negative for human papillomavirus, CANCER RESEARCH, Vol: 60, Pages: 6875-6877, ISSN: 0008-5472
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- Citations: 68
Smith PR, de Jesus O, Turner D, et al., 2000, Structure and coding content of CST (BART) family RNAs of Epstein-Barr virus, JOURNAL OF VIROLOGY, Vol: 74, Pages: 3082-3092, ISSN: 0022-538X
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- Citations: 105
Jenkins PJ, Binné UK, Farrell PJ, 2000, Histone acetylation and reactivation of Epstein-Barr virus from latency, JOURNAL OF VIROLOGY, Vol: 74, Pages: 710-720, ISSN: 0022-538X
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- Citations: 109
Wensing B, Farrell PJ, 2000, Regulation of cell growth and death by Epstein-Barr virus, MICROBES AND INFECTION, Vol: 2, Pages: 77-84, ISSN: 1286-4579
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- Citations: 26
Kiermaier A, Gawn JM, Desbarats L, et al., 1999, DNA binding of USF is required for specific E-box dependent gene activation <i>in vivo</i>, ONCOGENE, Vol: 18, Pages: 7200-7211, ISSN: 0950-9232
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- Citations: 23
Spender LC, Cannell EJ, Hollyoake M, et al., 1999, Control of cell cycle entry and apoptosis in B lymphocytes infected by Epstein-Barr virus, JOURNAL OF VIROLOGY, Vol: 73, Pages: 4678-4688, ISSN: 0022-538X
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- Citations: 60
Cannell EJ, Farrell PJ, Sinclair AJ, 1998, Cell cycle arrest following exposure of EBV-immortalised B-cells to gamma irradiation correlates with inhibition of cdk2 activity, FEBS LETTERS, Vol: 439, Pages: 297-301, ISSN: 0014-5793
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- Citations: 13
Farrell PJ, 1998, Signal transduction from the Epstein-Barr virus LMP-1 transforming protein, TRENDS IN MICROBIOLOGY, Vol: 6, Pages: 175-177, ISSN: 0966-842X
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- Citations: 47
Cludts I, Farrell PJ, 1998, Multiple functions within the Epstein-Barr virus EBNA-3A protein, JOURNAL OF VIROLOGY, Vol: 72, Pages: 1862-1869, ISSN: 0022-538X
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- Citations: 46
Radkov SA, Bain M, Farrell PJ, et al., 1997, Epstein-Barr virus EBNA3C represses Cp, the major promoter for EBNA expression, but has no effect on the promoter of the cell gene CD21, JOURNAL OF VIROLOGY, Vol: 71, Pages: 8552-8562, ISSN: 0022-538X
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- Citations: 87
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