Publications
164 results found
BAER R, BANKIER AT, BIGGIN MD, et al., 1984, DNA-SEQUENCE AND EXPRESSION OF THE B95-8 EPSTEIN-BARR VIRUS GENOME, NATURE, Vol: 310, Pages: 207-211, ISSN: 0028-0836
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- Citations: 1885
Bankier AT, Deininger PL, Satchwell SC, et al., 1983, DNA sequence analysis of the EcoRI Dhet fragment of B95-8 Epstein-Barr virus containing the terminal repeat sequences., Mol Biol Med, Vol: 1, Pages: 425-445, ISSN: 0735-1313
An analysis of the approximately 12,440 base-pair sequence of the EcoRI Dhet fragment isolated from the circular episomal form of the B95-8 strain of Epstein-Barr virus is presented. This fragment contains the covalently joined ends of the intracellular episomal form of the molecule. In the viral capsid the DNA is linear and the joining is mediated via the terminal repeated DNA. Four copies of tandem repeated DNA were present in this clone, three with a repeat size of 538 and one of 523. The positions of a number of possible protein coding regions and transcription signals are discussed. In particular a possible spliced coding region for an approximately 45,000 Mr protein expressed in latently infected transformed cells is proposed. The predicted protein sequence contains hydrophobic regions separated by charged amino acids reminiscent of a membrane protein.
Séguin C, Farrell PJ, Barrell BG, 1983, DNA sequence and transcription of the BamHI fragment B region of B95-8 Epstein-Barr virus., Mol Biol Med, Vol: 1, Pages: 369-392, ISSN: 0735-1313
The DNA sequence of the BamHI fragments B and the contiguous portion of G extending from the BamHI site to the EcoRI site of the B95-8 strain of Epstein-Barr virus has been determined. The sequence has been analysed for possible protein coding regions and transcriptional control sites. At least eight large open reading frames were found. Several RNA polymerase II promoters have been identified in the BamHI-B fragments. RNAs transcribed from these promoters are substantially induced by treatment of B95-8 cells with 12-O-tetradecanoylphorbol-13-acetate. Phosphonoacetic acid reversed the stimulatory effect of 12-O-tetradecanoylphorbol-13-acetate on the transcription of these RNAs indicating that they are late RNAs.
Bankier AT, Deininger PL, Farrell PJ, et al., 1983, Sequence analysis of the 17,166 base-pair EcoRI fragment C of B95-8 Epstein-Barr virus., Mol Biol Med, Vol: 1, Pages: 21-45, ISSN: 0735-1313
In order to provide a framework for understanding the molecular biology of Epstein-Barr virus (EBV), we are determining the DNA sequence of the virus and studying the organization of genes on the viral genome. In this paper we report the DNA sequence of the EcoRI C fragment of the B95-8 strain of EBV. The large (approximately 13.6 kb) deletion in this strain has been located by comparison with the DNA sequence of EBV isolated from Raji cells. The sequence has been analysed for possible protein coding regions and transcriptional control sites. At least eight large open reading frames are found, some of them associated with canonical promoter and polyadenylation sequences. The sequences of some of the encoded proteins suggest that they are membrane proteins. It is known that antibodies to major membrane glycoproteins of EBV can neutralize infection in tissue culture. A possible relationship between some of the encoded proteins and the major membrane glycoproteins of the virus is discussed.
FARRELL PJ, BANKIER A, SEGUIN C, et al., 1983, LATENT AND LYTIC CYCLE PROMOTERS OF EPSTEIN-BARR VIRUS, EMBO JOURNAL, Vol: 2, Pages: 1331-1338, ISSN: 0261-4189
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- Citations: 22
FARRELL PJ, DEININGER PL, BANKIER A, et al., 1983, HOMOLOGOUS UPSTREAM SEQUENCES NEAR EPSTEIN-BARR VIRUS PROMOTERS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, Vol: 80, Pages: 1565-1569, ISSN: 0027-8424
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- Citations: 73
DOUGHERTY JP, SAMANTA H, FARRELL PJ, et al., 1980, INTERFERON, DOUBLE-STRANDED-RNA, AND RNA DEGRADATION - ISOLATION OF HOMOGENEOUS PPPA(2'P5'A)N-1 SYNTHETASE FROM EHRLICH ASCITES TUMOR-CELLS, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 255, Pages: 3813-3816, ISSN: 0021-9258
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- Citations: 82
FARRELL PJ, BROEZE RJ, LENGYEL P, 1979, ACCUMULATION OF AN MESSENGER-RNA AND PROTEIN IN INTERFERON-TREATED EHRLICH ASCITES TUMOR-CELLS, NATURE, Vol: 279, Pages: 523-525, ISSN: 0028-0836
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- Citations: 248
FARRELL PJ, HUNT T, JACKSON RJ, 1978, ANALYSIS OF PHOSPHORYLATION OF PROTEIN-SYNTHESIS INITIATION-FACTOR EIF-2 BY 2-DIMENSIONAL GEL-ELECTROPHORESIS, EUROPEAN JOURNAL OF BIOCHEMISTRY, Vol: 89, Pages: 517-521, ISSN: 0014-2956
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- Citations: 82
RATNER L, WIEGAND RC, FARRELL PJ, et al., 1978, INTERFERON, DOUBLE-STRANDED-RNA AND RNA DEGRADATION - FRACTIONATION OF ENDONUCLEASE INT SYSTEM INTO 2 MACROMOLECULAR COMPONENTS - ROLE OF A SMALL MOLECULE IN NUCLEASE ACTIVATION, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol: 81, Pages: 947-954, ISSN: 0006-291X
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- Citations: 115
FARRELL PJ, SEN GC, DUBOIS MF, et al., 1978, INTERFERON ACTION - 2 DISTINCT PATHWAYS FOR INHIBITION OF PROTEIN-SYNTHESIS BY DOUBLE-STRANDED-RNA, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 75, Pages: 5893-5897, ISSN: 0027-8424
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- Citations: 213
FARRELL PJ, BALKOW K, HUNT T, et al., 1977, PHOSPHORYLATION OF INITIATION-FACTOR ELF-2 AND CONTROL OF RETICULOCYTE PROTEIN-SYNTHESIS, CELL, Vol: 11, Pages: 187-200, ISSN: 0092-8674
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- Citations: 685
COOPER JA, FARRELL PJ, 1977, EXTRACTS OF INTERFERON-TREATED CELLS CAN INHIBIT RETICULOCYTE LYSATE PROTEIN-SYNTHESIS, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol: 77, Pages: 124-131, ISSN: 0006-291X
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- Citations: 48
HUNTER AR, FARRELL PJ, JACKSON RJ, et al., 1977, ROLE OF POLYAMINES IN CELL-FREE PROTEIN-SYNTHESIS IN WHEAT-GERM SYSTEM, EUROPEAN JOURNAL OF BIOCHEMISTRY, Vol: 75, Pages: 149-157, ISSN: 0014-2956
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- Citations: 131
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