Imperial College London

ProfessorPaulFreemont

Faculty of MedicineDepartment of Medicine

Chair in Protein Crystallography
 
 
 
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Contact

 

+44 (0)20 7594 5327p.freemont

 
 
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Location

 

259Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Summary

Professor Freemont is Head of the Section of Structural Biology in the Department of Medicine at Imperial College. The Section is based in South Kensington Sir Alexander Fleming Building and focuses on the molecular mechanisms of human disease using the tools of integrated structural biology comprising X-ray crystallography, Cryo-EM and associated biophysical, spectroscopic and cellular techniques. The Section is also leading the London Consortium for Cryo-EM (LonCEM) with partners Kings College, Institute of Cancer Research, Queen Mary University and the Francis Crick Institute. In addition the Section also has research programs  in synthetic biology focused on automation, cell free systems, low cost viral and pathogenic biosensors and novel natural product discovery. Please go to the Structural Biology Section website  for news, up-to-date research summaries, a list of job opportunities, and information on lab members.

Professor Freemont is also co-founder of Imperial College Centre for Synthetic Biology (2009) and co-founder/co-director of the National UK Innovation and Knowledge Centre for Synthetic Biology (SynbiCITE; since Oct 2013) at Imperial College London. The Centre aims to enable synthetic biology research in application areas like biosensors,  biosynthesis, bioprocessing and metabolic and genome engineering and enable the translation of new synthetic biology technologies into start-ups, SME's and industry.  Previous to this he was head of the Division of Molecular Biosciences at Imperial (now the Department of Life Sciences), and head of the Centre for Structural Biology having joined Imperial from Cancer Research UK London Research Institute (now known as the Francis Crick Institute) where he was a Principal Scientist. His research interests span from understanding  molecular mechanisms associated with human disease states using structural molecular biology techniques to the development of synthetic biology cell-free and platform technologies for healthcare applications.

Publications

Journals

Kelwick RJR, Ricci L, Chee SM, et al., 2019, Cell-free prototyping strategies for enhancing the sustainable production of polyhydroxyalkanoates bioplastics, Synthetic Biology, Vol:3, ISSN:2397-7000

Hillson N, Caddick M, Cai Y, et al., 2019, Building a global alliance of biofoundries, Nature Communications, Vol:10, ISSN:2041-1723

Suckling L, McFarlane C, Sawyer C, et al., 2019, Miniaturisation of high-throughput plasmid DNA library preparation for next-generation sequencing using multifactorial optimisation, Synthetic and Systems Biotechnology, Vol:4, ISSN:2405-805X, Pages:57-66

Tosi T, Hoshiga F, Millership C, et al., 2019, Inhibition of the Staphylococcus aureus c-di-AMP cyclase DacA by direct interaction with the phosphoglucosamine mutase GlmM, Plos Pathogens, Vol:15, ISSN:1553-7366

Conference

Thaore V, Moore S, Polizzi K, et al., Cell-free multi-enzyme system for the industrial production of fine chemicals, Chemical Engineering Day UK 2019

More Publications