Imperial College London
Professor Philippe Froguel

ProfessorPhilippeFroguel

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Chair in Genomic Medicine
 
 
 
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Contact

 

+44 (0)20 7594 6520p.froguel

 
 
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Assistant

 

Mrs Patricia Murphy +44 (0)20 7594 1603

 
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Location

 

E306Burlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Lizzete:2017:2017/2432957,
author = {Lizzete, Antunez-Ortiz D and Flores-Alfaro, E and Isabel, Burguete-Garcia A and Bonnefond, A and Peralta-Romero, J and Froguel, P and Espinoza-Rojo, M and Cruz, M},
doi = {2017/2432957},
journal = {BioMed Research International},
title = {Copy number variations in candidate genes and intergenic regions affect body mass index and abdominal obesity in Mexican children},
url = {http://dx.doi.org/10.1155/2017/2432957},
volume = {2017},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Introduction. Increase in body weight is a gradual process that usually begins in childhood and in adolescence as a result of multiple interactions among environmental and genetic factors. This study aimed to analyze the relationship between copy number variants (CNVs) in five genes and four intergenic regions with obesity in Mexican children. Methods. We studied 1423 children aged 6–12 years. Anthropometric measurements and blood levels of biochemical parameters were obtained. Identification of CNVs was performed by real-time PCR. The effect of CNVs on obesity or body composition was assessed using regression models adjusted for age, gender, and family history of obesity. Results. Gains in copy numbers of LEPR and NEGR1 were associated with decreased body mass index (BMI), waist circumference (WC), and risk of abdominal obesity, whereas gain in ARHGEF4 and CPXCR1 and the intergenic regions 12q15c, 15q21.1a, and 22q11.21d and losses in INS were associated with increased BMI and WC. Conclusion. Our results indicate a possible contribution of CNVs in LEPR, NEGR1, ARHGEF4, and CPXCR1 and the intergenic regions 12q15c, 15q21.1a, and 22q11.21d to the development of obesity, particularly abdominal obesity in Mexican children.
AU  - Lizzete,Antunez-Ortiz D
AU  - Flores-Alfaro,E
AU  - Isabel,Burguete-Garcia A
AU  - Bonnefond,A
AU  - Peralta-Romero,J
AU  - Froguel,P
AU  - Espinoza-Rojo,M
AU  - Cruz,M
DO  - 2017/2432957
PY  - 2017///
SN  - 2314-6133
TI  - Copy number variations in candidate genes and intergenic regions affect body mass index and abdominal obesity in Mexican children
T2  - BioMed Research International
UR  - http://dx.doi.org/10.1155/2017/2432957
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000399202800001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/51153
VL  - 2017
ER  -
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