Imperial College London
Alternate

Emeritus ProfessorPeterGoldstraw

Faculty of Medicine, National Heart & Lung Institute

Emeritus Professor of Thoracic Surgery
 
 
 
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Contact

 

+44 (0)1803 834 171p.goldstraw

 
 
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Location

 

3062Sydney StreetRoyal Brompton Campus

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Summary

 

Publications

Publication Type
Year
to

292 results found

Thorley AJ, Ford PA, Giembycz MA, Goldstraw P, Young A, Tetley TDet al., 2007, Differential regulation of cytokine release and leukocyte migration by lipopolysaccharide-stimulated primary human lung alveolar type II epithelial cells and macrophages, JOURNAL OF IMMUNOLOGY, Vol: 178, Pages: 463-473, ISSN: 0022-1767

Journal article

Pilling JE, Nicholson AG, Harmer C, Goldstraw Pet al., 2007, Prolonged survival due to spontaneous regression and surgical excision of malignant mesothelioma, ANNALS OF THORACIC SURGERY, Vol: 83, Pages: 314-315, ISSN: 0003-4975

Journal article

Belcher E, Goldstraw P, 2007, Is radical mediastinal dissection mandatory for curative resection of NSCLC?, EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, Vol: 31, Pages: 142-143, ISSN: 1010-7940

Journal article

Dusmet M, Goldstraw P, Mittal TK, Padley Set al., 2007, Imaging features of isolated unilateral pulmonary artery agenesis presenting in adulthood: a review of four cases, Clinical radiology

Journal article

Edkins S, O'Meara S, Parker A, Stevens C, Reis M, Jones S, Greenman C, Davies H, Dalgliesh G, Forbes S, Hunter C, Smith R, Stephens P, Goldstraw P, Nicholson A, Chan TL, Velculescu VE, Yuen ST, Leung SY, Stratton MR, Futreal PAet al., 2006, Recurrent KRAS Codon 146 mutations in human colorectal cancer, CANCER BIOL THER, Vol: 5, Pages: 928-932, ISSN: 1538-4047

<p>An activating point mutation in codon 12 of the HRAS gene was the first somatic point mutation identified in a human cancer and established the role of somatic mutations as the common driver of oncogenesis. Since then, there have been over 11,000 mutations in the three RAS (HRAS, KRAS and NRAS) genes in codons 12, 13 and 61 reported in the literature. We report here the identification of recurrent somatic missense mutations at alanine 146, a highly conserved residue in the guanine nucleotide binding domain. In two independent series of colorectal cancers from Hong Kong and the United States we detected KRAS A146 mutations in 7/126 and 2/94 cases, respectively, giving a combined frequency of 4%. We also detected KRAS A146 mutations in 2/40 (5%) colorectal cell lines, including the NCI-60 colorectal cancer line HCC2998. Codon 146 mutations thus are likely to make an equal or greater contribution to colorectal cancer than codon 61 mutations (4.2% in our combined series, 1% in the literature). Lung adenocarcinomas and large cell carcinomas did not show codon 146 mutations. We did, however, identify a KRAS A146 mutation in the ML-2 acute myeloid leukemia cell line and an NRAS A146 mutation in the NALM-6 B-cell acute lymphoblastic leukemia line, suggesting that the contribution of codon 146 mutations is not entirely restricted to colorectal cancers or to KRAS.</p>

Journal article

Moore AJ, Stubbings A, Swallow EB, Dusmet M, Goldstraw P, Porcher R, Moxham J, Polkey MI, Ferenczi MAet al., 2006, Passive properties of the diaphragm in COPD, JOURNAL OF APPLIED PHYSIOLOGY, Vol: 101, Pages: 1400-1405, ISSN: 8750-7587

Journal article

Rusch VW, Tsuchiya R, Tsuboi M, Pass HI, Grunenwald D, Goldstraw Pet al., 2006, Surgery for bronchioloalveolar carcinoma and "very early" adenocarcinoma: An evolving standard of care?, International Symposium on Bronchioloalveolar Cell Carcinoma (BAC), Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: S27-S31, ISSN: 1556-0864

Conference paper

Edkins S, O'Meara S, Parker A, Stevens C, Reis M, Jones S, Greenman C, Davies H, Dalgliesh G, Forbes S, Hunter C, Smith R, Stephens P, Goldstraw P, Nicholson A, Chan TL, Velculescu VE, Yuen ST, Leung SY, Stration MR, Futreal PAet al., 2006, Recurrent <i>KRAS</i> Codon 146 mutations in human colorectal cancer, CANCER BIOLOGY & THERAPY, Vol: 5, Pages: 928-932, ISSN: 1538-4047

Journal article

Goldstraw P, 2006, Selection of patients for surgery after induction chemotherapy for N2 non-small-cell lung cancer, JOURNAL OF CLINICAL ONCOLOGY, Vol: 24, Pages: 3317-3318, ISSN: 0732-183X

Journal article

Phadnis J, Pilling JE, Evans TW, Goldstraw Pet al., 2006, Abdominal compartment syndrome: A rare complication of plication of the diaphragm, ANNALS OF THORACIC SURGERY, Vol: 82, Pages: 334-336, ISSN: 0003-4975

Journal article

Tansley P, Al-Mulhim F, Lim E, Ladas G, Goldstraw Pet al., 2006, A prospective, randomized, controlled trial of the effectiveness of BioGlue in treating alveolar air leaks, JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, Vol: 132, Pages: 105-112, ISSN: 0022-5223

Journal article

Goldstraw P, Crowley JJ, 2006, The International Association for the Study of Lung Cancer International Staging Project on Lung Cancer, JOURNAL OF THORACIC ONCOLOGY, Vol: 1, Pages: 281-286, ISSN: 1556-0864

Journal article

Lim E, Ali A, Cartwright N, Sousa I, Chetwynd A, Polkey M, Geddes D, Pepper J, Diggle P, Goldstraw Pet al., 2006, Effect and duration of lung volume reduction surgery: Mid-term results of the Brompton trial, THORACIC AND CARDIOVASCULAR SURGEON, Vol: 54, Pages: 188-192, ISSN: 0171-6425

Journal article

Krasopoulos G, Dusmet M, Ladas G, Goldstraw Pet al., 2006, Nuss procedure improves the quality of life in young mate adults with pectus excavatum deformity, EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, Vol: 29, Pages: 1-5, ISSN: 1010-7940

Journal article

Lantuejoul S, Ferretti GR, Goldstraw P, Hansell DM, Brambilla E, Nicholson AGet al., 2006, Metastases from bronchioloalveolar carcinomas associated with long-standing type 1 congenital cystic adenomatoid malformations. A report of two cases, HISTOPATHOLOGY, Vol: 48, Pages: 204-206, ISSN: 0309-0167

Journal article

Rami-Porta R, Wittekind C, Goldstraw P, 2006, Complete resection in lung cancer surgery: proposed definition by R. Rami-Porta, C. Wittekind and P. Goldstraw - Reply, LUNG CANCER, Vol: 51, Pages: 133-134, ISSN: 0169-5002

Journal article

Catarino PA, Goldstraw P, 2006, The future in diagnosis and staging of lung cancer - Surgical techniques, RESPIRATION, Vol: 73, Pages: 717-732, ISSN: 0025-7931

Journal article

Upile T, Triaridis S, Kirkland P, Goldstraw P, Evans PRet al., 2005, How we do it: the anterior thoraco-cervical approach to tumours of the thoracic inlet, CLINICAL OTOLARYNGOLOGY, Vol: 30, Pages: 561-565, ISSN: 1749-4478

Journal article

Goldstraw P, 2005, Invited commentary., Ann Thorac Surg, Vol: 80, Pages: 2324-2325

Journal article

Smith I, Groen HJM, van Meerbeeck J, Gilligan D, Goldstraw P, Manegold C, Nicolson M, Chung C, Hodson A, Stephens RJet al., 2005, The impact of giving neo-adjuvant chemotherapy for patients with non-small cell lung cancer (NSCLC): data from the MRC LU22/NVALT/EORTC 08012 randomised clinical trial, EJC SUPPLEMENTS, Vol: 3, Pages: 323-324, ISSN: 1359-6349

Journal article

Lim E, Yap YK, De Stavola BL, Nicholson AG, Goldstraw Pet al., 2005, The impact of stage and cell type on the prognosis of pulmonary neuroendocrine tumors, JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, Vol: 130, Pages: 969-972, ISSN: 0022-5223

Journal article

Davies H, Hunter C, Smith R, Stephens P, Greenman C, Bignell G, Teague B, Butler A, Edkins S, Stevens C, Parker A, O'Meara S, Avis T, Barthorpe S, Brackenbury L, Buck G, Clements B, Cole J, Dicks E, Edwards K, Forbes S, Gorton M, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jones D, Kosmidou V, Laman R, Lugg R, Menzies A, Perry J, Petty R, Raine K, Shepherd R, Small A, Solomon H, Stephens Y, Tofts C, Varian J, Webb A, West S, Widaa S, Yates A, Brasseur F, Cooper CS, Flanagan AM, Green A, Knowles M, Leung SY, Looijenga LHJ, Malkowicz B, Pierotti MA, Teh BT, Yuen ST, Lakhani SR, Easton DF, Weber BL, Goldstraw P, Nicholson AG, Wooster R, Stratton MR, Futreal PAet al., 2005, Somatic mutations of the protein kinase gene family in human lung cancer, CANCER RESEARCH, Vol: 65, Pages: 7591-7595, ISSN: 0008-5472

Journal article

Foster NA, Banerjee AK, Xian J, Roberts I, Pezzella F, Coleman N, Nicholson AG, Goldstraw P, George JP, Rabbitts PHet al., 2005, Somatic genetic changes accompanying lung tumor development, GENES CHROMOSOMES & CANCER, Vol: 44, Pages: 65-75, ISSN: 1045-2257

Journal article

Goldstraw P, 2005, The IASLC Staging Project: an overview of progress to date, 11th World Conference on Lung Cancer, Publisher: ELSEVIER IRELAND LTD, Pages: S40-S41, ISSN: 0169-5002

Conference paper

Rami-Porta R, Wittekind C, Goldstraw P, 2005, Complete resection in lung cancer surgery: proposed definition, LUNG CANCER, Vol: 49, Pages: 25-33, ISSN: 0169-5002

Journal article

Thorley AJ, Goldstraw P, Young A, Tetley TDet al., 2005, Primary human alveolar type II eplithelial cell CCL20 (macrophage inflammatory protein-3α)-induced dendritic cell migration, AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, Vol: 32, Pages: 262-267, ISSN: 1044-1549

Journal article

Muntimadugu BT, Goldstraw P, 2005, Fixed and dynamic airway obstruction in polychondritis, EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, Vol: 27, Pages: 705-705, ISSN: 1010-7940

Journal article

Hopkinson NS, Toma TP, Hansell DM, Goldstraw P, Moxharn J, Geddes DM, Polkey MIet al., 2005, Effect of Bronchoscopic lung volume reduction on dynamic hyperinflation and exercise in emphysema, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 171, Pages: 453-460, ISSN: 1073-449X

Journal article

Tezel CS, Goldstraw P, 2005, Plombage thoracoplasty with Lucite balls, ANNALS OF THORACIC SURGERY, Vol: 79, Pages: 1063-1063, ISSN: 0003-4975

Journal article

Hu JT, Bianchi F, Ferguson M, Cesario A, Margaritora S, Granone P, Goldstraw P, Tetlow M, Ratcliffe C, Nicholson AG, Harris A, Gatter K, Pezzella Fet al., 2005, Gene expression signature for angiogenic and nonangiogenic non-small-cell lung cancer, ONCOGENE, Vol: 24, Pages: 1212-1219, ISSN: 0950-9232

Journal article

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