Imperial College London

Dr Pau Herrero-Viñas

Faculty of EngineeringDepartment of Electrical and Electronic Engineering

Research Fellow
 
 
 
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Contact

 

p.herrero-vinias CV

 
 
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Location

 

B422Bessemer BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Avari:2019:10.1089/dia.2019.0276,
author = {Avari, P and Uduku, C and George, D and Herrero, P and Reddy, M and Oliver, N},
doi = {10.1089/dia.2019.0276},
journal = {Diabetes Technol Ther},
title = {Differences for Percentage Times in Glycemic Range Between Continuous Glucose Monitoring and Capillary Blood Glucose Monitoring in Adults with Type 1 Diabetes: Analysis of the REPLACE-BG Dataset.},
url = {http://dx.doi.org/10.1089/dia.2019.0276},
year = {2019}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Background: Self-monitored blood glucose (SMBG) and real-time continuous glucose monitoring (rtCGM) are used by people living with type 1 diabetes (T1D) to assess glucose and inform decision-making. Percentage time in range (%TIR) between 3.9 and 10 mmol/L has been associated with incident microvascular complications using historical SMBG data. However, the association between %TIR calculated from rtCGM data has not been identified. This study investigates whether %TIR values generated from rtCGM and SMBG data significantly differ from each other in adults with T1D. Materials and Methods: rtCGM and SMBG data from the REPLACE-BG study were obtained and analyzed. The dataset contained rtCGM (Dexcom G4 Platinum) and SMBG (Contour Next) values for 226 participants during a run-in phase lasting up to 10 weeks, followed by the 26-week trial. Percentages times in hypoglycemic, euglycemia and hyperglycemic ranges were generated from rtCGM and SMBG data using last observation carry forward method (zero-order hold) and linear interpolation (first-order hold). Results: Participants had a median (interquartile range [IQR]) age of 43.0 (31.0-55.0) years, and hemoglobin A1C of 53 (49-57) mmol/mol [7.0 (6.6-7.4)%]. The median (IQR) %TIR was significantly higher with rtCGM than with SMBG; 63.0 (55.9-71.0)% versus 54.6 (45.6-63.0)%, respectively, P < 0.001. Median %times in hypoglycemia and hyperglycemia were significantly different with SMBG than rtCGM (P < 0.001). SMBG-derived data using linear interpolation significantly differed from the carry forward method (P < 0.001 for all glycemic ranges). Differences reported were greater at night than during the day (P < 0.001 for all glycemic ranges). Conclusion: The %time in all glycemic ranges reported by SMBG an
AU - Avari,P
AU - Uduku,C
AU - George,D
AU - Herrero,P
AU - Reddy,M
AU - Oliver,N
DO - 10.1089/dia.2019.0276
PY - 2019///
TI - Differences for Percentage Times in Glycemic Range Between Continuous Glucose Monitoring and Capillary Blood Glucose Monitoring in Adults with Type 1 Diabetes: Analysis of the REPLACE-BG Dataset.
T2 - Diabetes Technol Ther
UR - http://dx.doi.org/10.1089/dia.2019.0276
UR - https://www.ncbi.nlm.nih.gov/pubmed/31613142
ER -