Imperial College London

Professor Peter Barnes, FRS

Faculty of MedicineNational Heart & Lung Institute

Margaret Turner-Warwick Chair
 
 
 
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Contact

 

+44 (0)20 7594 7959p.j.barnes Website

 
 
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Assistant

 

Miss Carolyn Green +44 (0)20 7594 7959

 
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Location

 

227CGuy Scadding BuildingRoyal Brompton Campus

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Summary

 

Publications

Publication Type
Year
to

2206 results found

Barnes PJ, 2019, Inflammatory Endotypes in COPD., Allergy

Chronic obstructive pulmonary disease (COPD) is a major global health problem that is poorly treated by current therapies as it has proved difficult to treat the underlying inflammation, which is largely corticosteroid-resistant in most patients. Although rare genetic endotypes of COPD have been recognised, despite the clinical heterogeneity of COPD it has proved difficult to identify distinct inflammatory endotypes. Most patients have increased neutrophils and macrophages in sputum, reflecting the increased secretion of neutrophil and monocyte chemotactic mediators in the lungs. However, some patients also have increased eosinophils in sputum and this may be reflected by increased blood eosinophils. Increased blood and sputum eosinophils are associated with more frequent exacerbations and predict a good response to corticosteroids in reducing and treating acute exacerbations. Eosinophilic COPD may represent an overlap with asthma but the mechanism of eosinophilia are uncertain as, although an increase in sputum IL-5 has been detected, anti-IL-5 therapies are not effective in preventing exacerbations. More research is needed to link inflammatory endotypes to clinical manifestations and outcomes in COPD and in particular to predict response to precision medicines. This article is protected by copyright. All rights reserved.

JOURNAL ARTICLE

Hakim A, Khan Y, Esteban I, Meah S, Miller-Larsson A, Barnes PJ, Usmani OSet al., 2019, Low-Dose Budesonide/Formoterol Counteracts Airway Inflammation and Improves Lung Function in Chronic Obstructive Pulmonary Disease, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 199, Pages: 662-664, ISSN: 1073-449X

JOURNAL ARTICLE

Jia M, Yan X, Jiang X, Wu Y, Xu J, Meng Y, Yang Y, Shan X, Zhang X, Mao S, Gu W, Pavlidis S, Barnes PJ, Adcock IM, Huang M, Yao Xet al., 2019, Ezrin, a Membrane Cytoskeleton Cross-Linker Protein, as a Marker of Epithelial Damage in Asthma, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 199, Pages: 496-507, ISSN: 1073-449X

JOURNAL ARTICLE

Baker JR, Vuppusetty C, Colley T, Hassibi S, Fenwick PS, Donnelly LE, Ito K, Barnes PJet al., 2019, MicroRNA-570 is a novel regulator of cellular senescence and inflammaging, FASEB JOURNAL, Vol: 33, Pages: 1605-1616, ISSN: 0892-6638

JOURNAL ARTICLE

Ghosh B, Gaike AH, Pyasi K, Brashier B, Das VV, Londhe JD, Juvekar S, Shouche YS, Donnelly LE, Salvi SS, Barnes PJet al., 2019, Bacterial load and defective monocyte-derived macrophage bacterial phagocytosis in biomass smoke-related COPD., Eur Respir J, Vol: 53

Lower airway colonisation with species of potentially pathogenic bacteria (PPB) is associated with defective bacterial phagocytosis, in monocyte-derived macrophages (MDMs) and alveolar macrophages, from tobacco smoke-associated chronic obstructive pulmonary disease (S-COPD) subjects. In the developing world, COPD among nonsmokers is largely due to biomass smoke (BMS) exposure; however, little is known about PPB colonisation and its association with impaired innate immunity in these subjects.We investigated the PPB load (Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis and Pseudomonas aeruginosa) in BMS-exposed COPD (BMS-COPD) subjects compared with S-COPD and spirometrically normal subjects. We also examined the association between PPB load and phagocytic activity of MDMs and lung function. Induced sputum and peripheral venous blood samples were collected from 18 healthy nonsmokers, 15 smokers without COPD, 16 BMS-exposed healthy subjects, 19 S-COPD subjects and 23 BMS-COPD subjects. PPB load in induced sputum and MDM phagocytic activity were determined using quantitative PCR and fluorimetry, respectively.Higher bacterial loads of S. pneumoniae, H. influenzae and P. aeruginosa were observed in BMS-COPD subjects. Increased PPB load in BMS-exposed subjects was significantly negatively associated with defective phagocytosis in MDMs and spirometric lung function indices (p<0.05).Increased PPB load in airways of BMS-COPD subjects is inversely associated with defective bacterial phagocytosis and lung function.

JOURNAL ARTICLE

Criner GJ, Martinez FJ, Aaron S, Agusti A, Anzueto A, Bafadhel M, Barnes PJ, Bourbeau J, Chen R, Ewig J, Fabbri LM, Frith P, Halpin DMG, Han M, Montes de Oca M, Nishimura M, O'Donnell D, Papi A, Pavord I, Roche N, Rodriguez-Roisin R, Salvi S, Singh D, Sin DD, Stockley R, Lopez Varela MV, Vestbo J, Vogelmeier CF, Washko G, Wedzicha JA, Celli BRet al., 2019, Current Controversies in Chronic Obstructive Pulmonary Disease A Report from the Global Initiative for Chronic Obstructive Lung Disease Scientific Committee, ANNALS OF THE AMERICAN THORACIC SOCIETY, Vol: 16, Pages: 29-39, ISSN: 1546-3222

JOURNAL ARTICLE

Izuhara K, Barnes PJ, 2019, Can We Define Asthma-COPD Overlap (ACO) by Biomarkers?, J Allergy Clin Immunol Pract, Vol: 7, Pages: 146-147

JOURNAL ARTICLE

Barnes PJ, 2018, THERAPY FOR ASTHMA AND COPD, Publisher: BMJ PUBLISHING GROUP, Pages: A2-A3, ISSN: 0032-5473

CONFERENCE PAPER

Dunne AE, Kawamatawong T, Fenwick PS, Davies CM, Tullett H, Barnes PJ, Donnelly LEet al., 2018, Direct Inhibitory Effect of the Phosphodiesterase-4 Inhibitor, Roflumilast, on Neutrophil Migration in COPD., Am J Respir Cell Mol Biol

Neutrophilic inflammation is characteristic of COPD, yet there are no effective anti-inflammatory therapies. The phosphodiesterase (PDE)4 inhibitor, roflumilast is approved for use in COPD and suppresses sputum neutrophilia. The mechanism underlying this observation is unclear and therefore this study addressed whether roflumilast directly affected neutrophil migration. Blood-derived neutrophils were isolated from non-smokers, smokers and COPD patients and chemotaxis measured using Boyden chambers. Intracellular calcium ion concentration ([Ca2+]i) was measured by fluorimetry and shape change and CD11b expression by flow cytometry. Neutrophils from COPD patients showed enhanced chemotactic responses towards both CXCL1 and LTB4 compared with control cells. Chemotaxis was inhibited by both the active metabolite, roflumilast-N-oxide, and rolipram in a concentration-dependent manner with no difference in responsiveness between subjects. Roflumilast-N-oxide and rolipram were less efficacious against CXCL1 and LTB4-mediated [Ca2+]i suggesting that inhibition was not via this pathway. Both PDE4 inhibitors attenuated chemoattractant-mediated shape change and CD11b up-regulation suggesting common mechanisms. The stable cAMP analogue, 8-Br-cAMP, inhibited chemotaxis, as did the direct Epac1 activator 8-pCPT-2'-O-Me-cAMP but not the direct PKA activator, 6-Bnz-cAMP. These data suggest that roflumilast inhibits neutrophil chemotaxis directly via a cAMP-mediated mechanism requiring activation of Epac1, and that Epac1 activators could reduce COPD neutrophilic inflammation.

JOURNAL ARTICLE

Carpagnano GE, Scioscia G, Lacedonia D, Soccio P, Lepore G, Saetta M, Barbaro MPF, Barnes PJet al., 2018, Looking for Airways Periostin in Severe Asthma Could It Be Useful for Clustering Type 2 Endotype?, CHEST, Vol: 154, Pages: 1083-1090, ISSN: 0012-3692

JOURNAL ARTICLE

Devereux G, Cotton S, Fielding S, McMeekin N, Bames PJ, Briggs A, Burns G, Chaudhuri R, Chrystyn H, Davies L, De Soyza A, Gompertz S, Haughney J, Innes K, Kaniewska J, Lee A, Morice A, Norrie J, Sullivan A, Wilson A, Price Det al., 2018, Effect of Theophylline as Adjunct to Inhaled Corticosteroids on Exacerbations in Patients With COPD A Randomized Clinical Trial, JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, Vol: 320, Pages: 1548-1559, ISSN: 0098-7484

JOURNAL ARTICLE

Cazzola M, Calzetta L, Barnes PJ, Criner GJ, Martinez FJ, Papi A, Matera MGet al., 2018, Efficacy and safety profile of xanthines in COPD: a network meta-analysis, 28th International Congress of the European-Respiratory-Society (ERS), Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936

CONFERENCE PAPER

O'Byrne P, Fitzgerald JM, Bateman ED, Barnes PJ, Zhong N, Keen C, Wang M, Lamarca R, Puu M, Reddel HKet al., 2018, Late Breaking Abstract - Risk of a severe exacerbation following higher reliever use: post-hoc analysis of SYGMA 1 in mild asthma, 28th International Congress of the European-Respiratory-Society (ERS), Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936

CONFERENCE PAPER

Bewley MA, Budd RC, Ryan E, Cole J, Collini P, Marshall J, Kolsum U, Beech G, Emes RD, Tcherniaeva I, Berbers GAM, Walmsley SR, Donaldson G, Wedzicha JA, Kilty I, Rumsey W, Sanchez Y, Brightling CE, Donnelly LE, Barnes PJ, Singh D, Whyte MKB, Dockrell DHet al., 2018, Opsonic Phagocytosis in Chronic Obstructive Pulmonary Disease Is Enhanced by Nrf2 Agonists, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 198, Pages: 739-750, ISSN: 1073-449X

JOURNAL ARTICLE

Mallia P, Webber J, Gill SK, Trujillo-Torralbo M-B, Calderazzo MA, Finney L, Bakhsoliani E, Fame H, Singanayagam A, Footitt J, Hewitt R, Kebadze T, Aniscenko J, Padmanaban V, Molyneaux PL, Adcock IM, Barnes PJ, Ito K, Elkin SL, Kon OM, Cookson WO, Moffat MF, Johnston SL, Tregoning JSet al., 2018, Role of airway glucose in bacterial infections in patients with chronic obstructive pulmonary disease, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 142, Pages: 815-+, ISSN: 0091-6749

JOURNAL ARTICLE

Maneechotesuwan K, Yao X, Ito K, Jazrawi E, Usmani OS, Adcock IM, Barnes PJet al., 2018, Correction: Suppression of GATA-3 Nuclear Import and Phosphorylation: A Novel Mechanism of Corticosteroid Action in Allergic Disease., PLoS Med, Vol: 15

[This corrects the article DOI: 10.1371/journal.pmed.1000076.].

JOURNAL ARTICLE

Pelleg A, Schulman ES, Barnes PJ, 2018, Adenosine 5 '-triphosphate's role in bradycardia and syncope associated with pulmonary embolism, RESPIRATORY RESEARCH, Vol: 19, ISSN: 1465-993X

JOURNAL ARTICLE

Dai Y, Yeo SCM, Barnes PJ, Donnelly LE, Loo LC, Lin H-Set al., 2018, Pre-clinical Pharmacokinetic and Metabolomic Analyses of Isorhapontigenin, a Dietary Resveratrol Derivative, FRONTIERS IN PHARMACOLOGY, Vol: 9, ISSN: 1663-9812

JOURNAL ARTICLE

Barnes PJ, 2018, Targeting cytokines to treat asthma and chronic obstructive pulmonary disease, NATURE REVIEWS IMMUNOLOGY, Vol: 18, Pages: 454-466, ISSN: 1474-1733

JOURNAL ARTICLE

Cazzola M, Calzetta L, Barnes PJ, Criner GJ, Martinez FJ, Papi A, Matera MGet al., 2018, Efficacy and safety profile of xanthines in COPD: a network meta-analysis, EUROPEAN RESPIRATORY REVIEW, Vol: 27, ISSN: 0905-9180

JOURNAL ARTICLE

O'Byrne PM, FitzGerald JM, Bateman ED, Barnes PJ, Zhong N, Keen C, Jorup C, Lamarca R, Ivanov S, Reddel HKet al., 2018, Inhaled Combined Budesonide-Formoterol as Needed in Mild Asthma, NEW ENGLAND JOURNAL OF MEDICINE, Vol: 378, Pages: 1865-1876, ISSN: 0028-4793

JOURNAL ARTICLE

Bateman ED, Reddel HK, O'Byrne PM, Barnes PJ, Zhong N, Keen C, Jorup C, Lamarca R, Siwek-Posluszna A, FitzGerald JMet al., 2018, As-Needed Budesonide-Formoterol versus Maintenance Budesonide in Mild Asthma, NEW ENGLAND JOURNAL OF MEDICINE, Vol: 378, Pages: 1877-1887, ISSN: 0028-4793

JOURNAL ARTICLE

Montuschi P, Santini G, Mores N, Vignoli A, Macagno F, Shoreh R, Tenori L, Zini G, Fuso L, Mondino C, Di Natale C, D'Amico A, Luchinat C, Barnes PJ, Higenbottam Tet al., 2018, Breathomics for Assessing the Effects of Treatment and Withdrawal With Inhaled Beclomethasone/Formoterol in Patients With COPD, FRONTIERS IN PHARMACOLOGY, Vol: 9, ISSN: 1663-9812

JOURNAL ARTICLE

Singh D, Barnes PJ, Stockley R, Lopez Valera MV, Vogelmeier C, Agusti Aet al., 2018, Pharmacological treatment of COPD: the devil is always in the detail, EUROPEAN RESPIRATORY JOURNAL, Vol: 51, ISSN: 0903-1936

JOURNAL ARTICLE

Wang Z, Singh R, Miller BE, Tal-Singer R, Van Horn S, Tomsho L, Mackay A, Allinson JP, Webb AJ, Brookes AJ, George LM, Barker B, Kolsum U, Donnelly LE, Belchamber K, Barnes PJ, Singh D, Brightling CE, Donaldson GC, Wedzicha JA, Brown JRet al., 2018, Sputum microbiome temporal variability and dysbiosis in chronic obstructive pulmonary disease exacerbations: an analysis of the COPDMAP study, THORAX, Vol: 73, Pages: 331-338, ISSN: 0040-6376

JOURNAL ARTICLE

Di Stefano A, Sangiorgi C, Gnemmi I, Casolari P, Brun P, Ricciardolo FLM, Contoli M, Papi A, Maniscalco P, Ruggeri P, Girbino G, Cappello F, Pavlides S, Guo Y, Chung KF, Barnes PJ, Adcock IM, Balbi B, Caramori Get al., 2018, TGF-beta Signaling Pathways in Different Compartments of the Lower Airways of Patients With Stable COPD, CHEST, Vol: 153, Pages: 851-862, ISSN: 0012-3692

JOURNAL ARTICLE

Hashemian SM, Mortaz E, Jamaati H, Bagheri L, Mohajerani SA, Garssen J, Movassaghi M, Barnes PJ, Hill NS, Adcock IMet al., 2018, Budesonide facilitates weaning from mechanical ventilation in difficult-to-wean very severe COPD patients: Association with inflammatory mediators and cells, JOURNAL OF CRITICAL CARE, Vol: 44, Pages: 161-167, ISSN: 0883-9441

JOURNAL ARTICLE

Yanagisawa S, Baker JR, Vuppusetty C, Koga T, Colley T, Fenwick P, Donnelly LE, Barnes PJ, Ito Ket al., 2018, The dynamic shuttling of SIRT1 between cytoplasm and nuclei in bronchial epithelial cells by single and repeated cigarette smoke exposure, PLOS ONE, Vol: 13, ISSN: 1932-6203

JOURNAL ARTICLE

Paschalaki KE, Zampetaki A, Baker JR, Birrell MA, Starke RD, Belvisi MG, Donnelly LE, Mayr M, Randi AM, Barnes PJet al., 2018, Downregulation of MicroRNA-126 Augments DNA Damage Response in Cigarette Smokers and Patients with Chronic Obstructive Pulmonary Disease, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 197, Pages: 665-668, ISSN: 1073-449X

JOURNAL ARTICLE

Birch J, Barnes PJ, Passos JF, 2018, Mitochondria, telomeres and cell senescence: Implications for lung ageing and disease, PHARMACOLOGY & THERAPEUTICS, Vol: 183, Pages: 34-49, ISSN: 0163-7258

JOURNAL ARTICLE

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