Publications
2498 results found
YUKAWA T, KROEGEL C, EVANS P, et al., 1989, DENSITY HETEROGENEITY OF EOSINOPHIL LEUKOCYTES - INDUCTION OF HYPODENSE EOSINOPHILS BY PLATELET-ACTIVATING FACTOR, IMMUNOLOGY, Vol: 68, Pages: 140-143, ISSN: 0019-2805
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- Citations: 44
MCCORMACK DG, MAK JCW, COUPE MO, et al., 1989, CALCITONIN GENE-RELATED PEPTIDE VASODILATION OF HUMAN PULMONARY VESSELS, JOURNAL OF APPLIED PHYSIOLOGY, Vol: 67, Pages: 1265-1270, ISSN: 8750-7587
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- Citations: 87
RHODEN KJ, BARNES PJ, 1989, EFFECT OF HYDROGEN-PEROXIDE ON GUINEA-PIG TRACHEAL SMOOTH-MUSCLE INVITRO - ROLE OF CYCLO-OXYGENASE AND AIRWAY EPITHELIUM, BRITISH JOURNAL OF PHARMACOLOGY, Vol: 98, Pages: 325-330, ISSN: 0007-1188
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- Citations: 80
BELVISI MG, ICHINOSE M, BARNES PJ, 1989, MODULATION OF NON-ADRENERGIC, NON-CHOLINERGIC NEURAL BRONCHOCONSTRICTION IN GUINEA-PIG AIRWAYS VIA GABAB-RECEPTORS, BRITISH JOURNAL OF PHARMACOLOGY, Vol: 97, Pages: 1225-1231, ISSN: 0007-1188
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- Citations: 68
Yukawa T, Kroegel C, Chanez P, et al., 1989, Effect of theophylline and adenosine on eosinophil function., Am Rev Respir Dis, Vol: 140, Pages: 327-333, ISSN: 0003-0805
Eosinophils may play a critical role in asthma and bronchial hyperresponsiveness, yet the effect of theophylline on their function is not certain. We have examined the effects of theophylline on opsonized zymosan-induced superoxide anion (O2-) release from guinea pig eosinophils harvested from the peritoneal cavity and from human eosinophils obtained by differential centrifugation of blood from patients with peripheral eosinophilia. Theophylline at high concentration (10(-3) M) inhibited O2- release by 27.6 +/- 9.4% (mean +/- SEM, p less than 0.05), whereas at clinically relevant concentrations (10(-6) and 10(-5) M), it significantly potentiated this by 26.8 +/- 9.9% (p less than 0.05) and 36.9 +/- 6.3% (p less than 0.01), respectively. 8-phenyltheophylline (10(-7) to 10(-3) M), which like theophylline inhibits adenosine receptors but does not inhibit phosphodiesterase activity, produced potentiation at all concentrations. Preincubation of eosinophils with adenosine deaminase (0.1 U/ml) enhanced O2- release by 72.4 +/- 15.2% (p less than 0.01), whereas addition of adenosine (3 x 10(-8) to 10(-6) M) reversed the potentiation induced by theophylline (10(-5) M) in a concentration-dependent manner. Inhibition was greater with the A2-selective analog N-ethylcarboxamide adenosine than the A1-selective analog phenylisopropyladenosine, suggesting that A2-receptors are involved. In human eosinophils we have demonstrated a similar effect of theophylline and adenosine on O2- release. Our results indicate that therapeutic concentrations of theophylline may potentiate eosinophil activation in vivo by competing with circulating adenosine for eosinophil A2-receptors. This would be consistent with the lack of effect of theophylline on bronchial hyperresponsiveness, which may be related to eosinophilic inflammation.
BARNES PJ, 1989, AIRWAY RECEPTORS, POSTGRADUATE MEDICAL JOURNAL, Vol: 65, Pages: 532-542, ISSN: 0032-5473
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- Citations: 4
YUKAWA T, KROEGEL C, CHANEZ P, et al., 1989, EFFECT OF THEOPHYLLINE AND ADENOSINE ON EOSINOPHIL FUNCTION, AMERICAN REVIEW OF RESPIRATORY DISEASE, Vol: 140, Pages: 327-333, ISSN: 0003-0805
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- Citations: 73
LAMMERS JWJ, MINETTE P, MCCUSKER MT, et al., 1989, CAPSAICIN-INDUCED BRONCHODILATION IN MILD ASTHMATIC SUBJECTS - POSSIBLE ROLE OF NONADRENERGIC INHIBITORY SYSTEM, JOURNAL OF APPLIED PHYSIOLOGY, Vol: 67, Pages: 856-861, ISSN: 8750-7587
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- Citations: 44
KROEGEL C, YUKAWA T, WESTWICK J, et al., 1989, EVIDENCE FOR 2 PLATELET ACTIVATING FACTOR RECEPTORS ON EOSINOPHILS - DISSOCIATION BETWEEN PAF-INDUCED INTRACELLULAR CALCIUM MOBILIZATION DE-GRANULATION AND SUPEROXIDES ANION GENERATION IN EOSINOPHILS, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol: 162, Pages: 511-521, ISSN: 0006-291X
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- Citations: 85
BARNES PJ, ICHINOSE M, 1989, H-3 RECEPTORS IN AIRWAYS, TRENDS IN PHARMACOLOGICAL SCIENCES, Vol: 10, Pages: 264-264, ISSN: 0165-6147
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- Citations: 15
STRETTON CD, BARNES PJ, 1989, CHOLECYSTOKININ-OCTAPEPTIDE CONSTRICTS GUINEA-PIG AND HUMAN AIRWAYS, BRITISH JOURNAL OF PHARMACOLOGY, Vol: 97, Pages: 675-682, ISSN: 0007-1188
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- Citations: 16
ROGERS DF, BOSCHETTO P, BARNES PJ, 1989, PLASMA EXUDATION - CORRELATION BETWEEN EVANS BLUE-DYE AND RADIOLABELED ALBUMIN IN GUINEA-PIG AIRWAYS INVIVO, JOURNAL OF PHARMACOLOGICAL METHODS, Vol: 21, Pages: 309-315, ISSN: 0160-5402
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- Citations: 192
DIXON CMS, BARNES PJ, 1989, BRADYKININ-INDUCED BRONCHOCONSTRICTION - INHIBITION BY NEDOCROMIL SODIUM AND SODIUM CROMOGLYCATE, BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, Vol: 27, Pages: 831-836, ISSN: 0306-5251
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- Citations: 101
BARNES PJ, 1989, NEW CONCEPTS IN THE PATHOGENESIS OF BRONCHIAL HYPERRESPONSIVENESS AND ASTHMA, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 83, Pages: 1013-1026, ISSN: 0091-6749
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- Citations: 437
IND PW, DIXON CMS, FULLER RW, et al., 1989, ANTICHOLINERGIC BLOCKADE OF BETA-BLOCKER-INDUCED BRONCHOCONSTRICTION, AMERICAN REVIEW OF RESPIRATORY DISEASE, Vol: 139, Pages: 1390-1394, ISSN: 0003-0805
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- Citations: 82
KIOUMIS I, UKENA D, BARNES PJ, 1989, EFFECT OF NEDOCROMIL SODIUM ON DOWN-REGULATION OF PULMONARY BETA-ADRENOCEPTORS, CLINICAL SCIENCE, Vol: 76, Pages: 599-602, ISSN: 0143-5221
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- Citations: 10
CHUNG KC, BARNES PJ, 1989, PLATELET-ACTIVATING FACTOR - A POTENT MEDIATOR OF INFLAMMATION, POSTGRADUATE MEDICAL JOURNAL, Vol: 65, Pages: 420-421, ISSN: 0032-5473
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- Citations: 5
MCCUSKER MT, CHUNG KF, ROBERTS NM, et al., 1989, EFFECT OF TOPICAL CAPSAICIN ON THE CUTANEOUS RESPONSES TO INFLAMMATORY MEDIATORS AND TO ANTIGEN IN MAN, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 83, Pages: 1118-1124, ISSN: 0091-6749
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- Citations: 33
BLACK PN, FULLER RW, TAYLOR GW, et al., 1989, EFFECT OF INHALED LEUKOTRIENE-B4 ALONE AND IN COMBINATION WITH PROSTAGLANDIN-D2 ON BRONCHIAL RESPONSIVENESS TO HISTAMINE IN NORMAL SUBJECTS, THORAX, Vol: 44, Pages: 491-495, ISSN: 0040-6376
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- Citations: 27
CHILVERS ER, CHALLISS RAJ, BARNES PJ, et al., 1989, MASS CHANGES OF INOSITOL(1,4,5) TRISPHOSPHATE IN TRACHEALIS MUSCLE FOLLOWING AGONIST STIMULATION, EUROPEAN JOURNAL OF PHARMACOLOGY, Vol: 164, Pages: 587-590, ISSN: 0014-2999
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- Citations: 70
MAK JCW, BARNES PJ, 1989, MUSCARINIC RECEPTOR SUBTYPES IN HUMAN AND GUINEA-PIG LUNG, EUROPEAN JOURNAL OF PHARMACOLOGY, Vol: 164, Pages: 223-230, ISSN: 0014-2999
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- Citations: 52
KROEGEL C, YUKAWA T, DENT G, et al., 1989, STIMULATION OF DE-GRANULATION FROM HUMAN EOSINOPHILS BY PLATELET-ACTIVATING FACTOR, JOURNAL OF IMMUNOLOGY, Vol: 142, Pages: 3518-3526, ISSN: 0022-1767
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- Citations: 217
UKENA D, KROGEL C, DENT G, et al., 1989, PAF-RECEPTORS ON EOSINOPHILS - IDENTIFICATION WITH A NOVEL LIGAND, [H-3] WEB-2086, BIOCHEMICAL PHARMACOLOGY, Vol: 38, Pages: 1702-1705, ISSN: 0006-2952
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- Citations: 55
BARNES PJ, CHUNG KF, 1989, PAF ANTAGONISTS IN ASTHMA, LANCET, Vol: 1, Pages: 1071-1072, ISSN: 0140-6736
ENGELS F, CARSTAIRS JR, BARNES PJ, et al., 1989, AUTORADIOGRAPHIC LOCALIZATION OF CHANGES IN PULMONARY BETA-ADRENOCEPTORS IN AN ANIMAL-MODEL OF ATOPY, EUROPEAN JOURNAL OF PHARMACOLOGY, Vol: 164, Pages: 139-146, ISSN: 0014-2999
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- Citations: 22
EVANS TW, ROGERS DF, AURSUDKIJ B, et al., 1989, REGIONAL AND TIME-DEPENDENT EFFECTS OF INFLAMMATORY MEDIATORS ON AIRWAY MICROVASCULAR PERMEABILITY IN THE GUINEA-PIG, CLINICAL SCIENCE, Vol: 76, Pages: 479-485, ISSN: 0143-5221
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- Citations: 54
HALL AK, BARNES PJ, MELDRUM LA, et al., 1989, FACILITATION BY TACHYKININS OF NEUROTRANSMISSION IN GUINEA-PIG PULMONARY PARASYMPATHETIC NERVES, BRITISH JOURNAL OF PHARMACOLOGY, Vol: 97, Pages: 274-280, ISSN: 0007-1188
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- Citations: 83
BARNES PJ, 1989, OUR CHANGING UNDERSTANDING OF ASTHMA, RESPIRATORY MEDICINE, Vol: 83, Pages: 17-23, ISSN: 0954-6111
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- Citations: 21
ICHINOSE M, STRETTON CD, SCHWARTZ JC, et al., 1989, HISTAMINE H-3-RECEPTORS INHIBIT CHOLINERGIC NEUROTRANSMISSION IN GUINEA-PIG AIRWAYS, BRITISH JOURNAL OF PHARMACOLOGY, Vol: 97, Pages: 13-15, ISSN: 0007-1188
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- Citations: 121
CORRIS P, KONIG P, WILLIAMS A, et al., 1989, THE ALTOUNYAN,ROGER MEMORIAL SYMPOSIUM - OCTOBER 8, 1988, CUMBRIA, UK - PANEL DISCUSSION, RESPIRATORY MEDICINE, Vol: 83, Pages: 49-53, ISSN: 0954-6111
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