Imperial College London
Alternate

Professor Sir Peter Barnes, FRS, FMedSci

Faculty of Medicine, National Heart & Lung Institute

Senior Research Investigator
 
 
 
//

Contact

 

+44 (0)20 7594 7959p.j.barnes Website CV

 
 
//

Assistant

 

Miss Carolyn Green +44 (0)20 7594 7959

 
//

Location

 

227CGuy Scadding BuildingRoyal Brompton Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Pelleg:2018:10.1186/s12931-018-0848-2,
author = {Pelleg, A and Schulman, ES and Barnes, PJ},
doi = {10.1186/s12931-018-0848-2},
journal = {RESPIRATORY RESEARCH},
title = {Adenosine 5 '-triphosphate's role in bradycardia and syncope associated with pulmonary embolism},
url = {http://dx.doi.org/10.1186/s12931-018-0848-2},
volume = {19},
year = {2018}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Adenosine 5′-triphiosphate (ATP) is released from cells under physiologic and pathophysiologic conditions. Extracellular ATP acts as an autocrine and paracrine agent affecting various cell types by activating cell surface P2 receptors (P2R), which include trans-cell membrane cationic channels, P2XR, and G protein coupled receptors, P2YR. We have previously shown that ATP stimulates vagal afferent nerve terminals in the lungs by activating P2X2/3R. This action could lead to bronchoconstriction, cough and the local release of pro-inflammatory neuropeptides. In addition, ATP markedly enhances the IgE-dependent histamine release from human lung mast cells. Thus, we have proposed for the first time that extracellular ATP plays a mechanistic role in pulmonary pathophysiology in general and chronic obstructive pulmonary disease (COPD), and acute bronchoconstriction in asthma in particular. The present review examines whether ATP could also play a role in bradycardia and syncope in a subset of patients with pulmonary embolism.
AU  - Pelleg,A
AU  - Schulman,ES
AU  - Barnes,PJ
DO  - 10.1186/s12931-018-0848-2
PY  - 2018///
SN  - 1465-993X
TI  - Adenosine 5 '-triphosphate's role in bradycardia and syncope associated with pulmonary embolism
T2  - RESPIRATORY RESEARCH
UR  - http://dx.doi.org/10.1186/s12931-018-0848-2
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000440219900002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/63470
VL  - 19
ER  -
Download