Imperial College London
Alternate

Dr Peter Kelleher

Faculty of Medicine, Department of Infectious Disease

Reader in Immunology
 
 
 
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Contact

 

+44 (0)20 3315 8251p.kelleher

 
 
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Location

 

J.2.10Chelsea and Westminster HospitalChelsea and Westminster Campus

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Summary

 

Publications

Citation

BibTex format

@article{Turner:2021:10.1016/j.jaip.2020.07.049,
author = {Turner, SEG and Loosemore, M and Shah, A and Kelleher, P and Hull, JH},
doi = {10.1016/j.jaip.2020.07.049},
journal = {Journal of Allergy and Clinical Immunology: In Practice},
pages = {151--159},
title = {Salivary IgA as a potential biomarker in the evaluation of respiratory tract infection risk in athletes},
url = {http://dx.doi.org/10.1016/j.jaip.2020.07.049},
volume = {9},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - In recent years, there has been attention focused on the value of salivary IgA (sIgA) as a potential biomarker for the identification of athletes who may be at increased risk of developing respiratory tract infection (RTI). The utility of sIgA, in this context, is based on biological plausibility and several observational studies revealing an apparent association between sIgA and RTI susceptibility. The overall published evidence evaluating the value of sIgA in this context is however conflicting, and there is currently a lack of clear guidance as to whether this marker has a place in the health surveillance and care of athletes. In this review, we critically appraise the literature assessing the potential for sIgA to be used in this context, evaluating it against 4 key biomarker characteristics, including its (1) practicality, (2) reproducibility, (3) specificity/sensitivity, and (4) potential clinical impact and relevance. This process reveals that although there is an apparent association between respiratory illness and sIgA in many studies, with some promising results, overall there remains a paucity of evidence supporting its overall value in this context. Key deficiencies in the metrics employed to endorse a valid biomarker are apparent, including a lack of reproducibility and low specificity and sensitivity in the detection of RTI susceptibility. The review outlines these issues and makes future recommendations.
AU  - Turner,SEG
AU  - Loosemore,M
AU  - Shah,A
AU  - Kelleher,P
AU  - Hull,JH
DO  - 10.1016/j.jaip.2020.07.049
EP  - 159
PY  - 2021///
SN  - 2213-2198
SP  - 151
TI  - Salivary IgA as a potential biomarker in the evaluation of respiratory tract infection risk in athletes
T2  - Journal of Allergy and Clinical Immunology: In Practice
UR  - http://dx.doi.org/10.1016/j.jaip.2020.07.049
UR  - https://www.ncbi.nlm.nih.gov/pubmed/32781048
UR  - https://www.sciencedirect.com/science/article/pii/S2213219820308072?via%3Dihub
UR  - http://hdl.handle.net/10044/1/84235
VL  - 9
ER  -
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