Until 2017, Peter Kohl held the Chair in Cardiac Biophysics and Systems Biology at NHLI. Having relocated to Germany, to set up the new institute for Experimental Cardiovascular Medicine at the University of Freiburg, he is now a Visiting Professor at NHLI.
Peter studied Medicine and Biophysics at the Moscow Pirogov Institute (1981-1987) and, after post-graduate training and research at the Berlin Charité (PhD 1990, Facharzt 1991), he joined the Cardiac Electrophysiology Chair of Professor Denis Noble at Oxford (1992). In 1998, Peter set up the Oxford Cardiac Mechano-Electric Feedback lab, initially as a Royal Society Research Fellow, and subsequently as a Senior Fellow of the British Heart Foundation. While at Oxford, he held a Research Fellowship at Keble College (2002-2004) and was the Tutorial Fellow in Biomedical Sciences at Balliol (2004-2010).
Peter’s team enjoys a strong international reputation in cardiac mechano-electrical interaction studies, in particular as a result of their ability to cross traditional boundaries between fields (engineering, biophysics, biology, computing) and levels (ion channel to whole organ) of investigation. Building on a solid track-record in the development and application of novel techniques, they combine experiment and computation to integrate cardiac structure-function data to address clinically-relevant research targets. The group maintains close links with leading experimental and modelling teams in the UK and elsewhere, including Auckland, Baltimore, Boulder, Ekaterinburg, Heidelberg and Okayama.
Peter directs a significant portfolio of externally-funded research (supported in recent years by ERC, BBSRC, EPSRC, BHF, and EC), and has been a driver of international collaboration actions, such as the Network of Excellence for the EU Virtual Physiological Human Initiative whose co-founding director he was. He serves on editorial boards and as a reviewer for international journals and funding bodies. Peter is the coordinating editor of the primary textbook on Cardiac Mechano-Electric Coupling and Arrhythmias, and chairman of the leading international workshop series on the same topic.
Selected publications (for full list see here):
Hulsmans M, Clauss S, Xiao L et al. Macrophages facilitate electrical conduction in the heart. Cell 2017/169:510-522.
Scardigli M, Crocini C, Ferrantini C et al. Quantitative assessment of passive electrical properties of the cardiac T-tubular system by FRAP microscopy. Proc Natl Acad Sci USA 2017/114:5737-5742.
Quinn TA, Camelliti P, Rog-Zielinska EA, Siedlecka U, Poggioli T, O'Toole ET, Knöpfel T & Kohl P. Electrotonic coupling of excitable and nonexcitable cells in the heart revealed by optogenetics. Proc Natl Acad Sci USA 2017:113:4852–14857.
Gourdie RG, Dimmeler S & Kohl P. Novel therapeutic strategies targeting fibroblasts and fibrosis in heart disease. Nature Reviews Drug Discovery 2016/15: 620–638.
Brandenburg S, Kohl T, Williams G et al. Axial tubule junctions control rapid calcium signaling in atria. J Clin Invest 2016/126:3999–4015
Peyronnet R, Nerbonne JM & Kohl P. Cardiac mechano-gated ion channels and arrhythmias. Circ Res 2016/118 (2), 311-329
EA Rog-Zielinska, RA Norris, P Kohl & R Markwald. The living scar - cardiac fibroblasts and the injured heart. Trends Mol Med 2016/22:99-114.
Kohl P & Gourdie RG. Fibroblast-myocyte electrotonic coupling: Does it occur in native cardiac tissue? J Mol Cell Cardiol 2014/70:37-46.
Botcherby et al. Fast measurement of sarcomere length and cell orientation in Langendorff-perfused hearts using remote focusing microscopy. Circ Res 2013/113:863-70.
Yan et al. Palette of fluorinated voltage-sensitive hemicyanine dyes. Proc Natl Acad Sci USA 2012/109:20443-8.
Lee et al. Simultaneous voltage and calcium mapping of genetically purified human induced pluripotent stem cell-derived cardiac myocyte monolayers. Circ Res 2012/110:1556-63.
Bub et al. Temporal pixel multiplexing for simultaneous high-speed, high-resolution imaging. Nat Methods 2010/7:209-11.
Iribe et al. Axial stretch of rat single ventricular cardiomyocytes causes an acute and transient increase in Ca2+ spark rate. Circ Res 2009/104:787-95.
Camelliti et al. Micropatterned cell cultures on elastic membranes as an in vitro model of myocardium. Nat Protoc 2006/1:1379-91.
Camelliti et al. Fibroblast network in rabbit sinoatrial node: structural and functional identification of homogeneous and heterogeneous cell coupling. Circ Res 2004/94:828-35.
Kroll KT, Zhou Q, Kohl P, 2017, Finding the culprit: who is turning hearts to stone?, Stem Cell Investig, Vol:4, ISSN:2306-9759
et al., 2017, Caveolae in Rabbit Ventricular Myocytes: Distribution and Dynamic Diminution after Cell Isolation, Biophysical Journal, Vol:113, ISSN:0006-3495, Pages:1047-1059
et al., 2017, Load-dependent effects of apelin on murine cardiomyocytes., Prog Biophys Mol Biol
et al., 2017, Optogenetic targeting of cardiac myocytes and non-myocytes: Tools, challenges and utility., Prog Biophys Mol Biol
et al., 2017, Evaluation of non-Gaussian diffusion in cardiac MRI, Magnetic Resonance in Medicine, Vol:78, ISSN:0740-3194, Pages:1174-1186