Peter Kohl holds the Chair in Cardiac Biophysics and Systems Biology at NHLI. He is currently setting up the new institute for Experimental Cardiovascular Medicine at the University of Freiburg in Germany, while continuing his association with NHLI part-time.
Peter studied Medicine and Biophysics at the Moscow Pirogov Institute (1981-1987) and, after post-graduate training and research at the Berlin Charité (PhD 1990, Facharzt 1991), he joined the Cardiac Electrophysiology Chair of Professor Denis Noble at Oxford (1992). In 1998, Peter set up the Oxford Cardiac Mechano-Electric Feedback lab, initially as a Royal Society Research Fellow, and subsequently as a Senior Fellow of the British Heart Foundation. While at Oxford, he held a Research Fellowship at Keble College (2002-2004) and was the Tutorial Fellow in Biomedical Sciences at Balliol (2004-2010).
Peter’s team enjoys a strong international reputation in cardiac mechano-electrical interaction studies, in particular as a result of their ability to cross traditional boundaries between fields (engineering, biophysics, biology, computing) and levels (ion channel to whole organ) of investigation. Building on a solid track-record in the development and application of novel techniques, they combine experiment and computation to integrate cardiac structure-function data to address clinically-relevant research targets. The group maintains close links with leading experimental and modelling teams in the UK and elsewhere, including Auckland, Baltimore, Boulder, Ekaterinburg, Heidelberg and Okayama.
Peter directs a significant portfolio of externally-funded research (supported by ERC, BBSRC, EPSRC, BHF, and EC), and has been a driver of international collaboration actions, such as the Network of Excellence for the EU Virtual Physiological Human Initiative whose founding director he was. He serves on editorial boards and as a reviewer for international journals and funding bodies. Peter is the coordinating editor of the primary textbook on Cardiac Mechano-Electric Coupling and Arrhythmias, and chairman of the leading international workshop series on the same topic.
For more detail, please see Andrew Czyzewski's 'news flash' and Peter's Inaugural Lecture at Imperial College, as well as Nature Reviews in Drug Discovery where a much noted paper argues the case for shaping scar formation - working with, rather than against, nature's repair mechanisms after cardiac injury.
NHLI-Based TEAM MEMBERS
Elizabeth Jones, Research Technician
Dr Remi Peyronnet, MYI Research Associate
Dr Eva Rog-Zielinska, BHF Immediate Post-doc Fellow
Dr Urszula Siedlecka, Lab Manager
Selected publications (for full list see here):
Gourdie RG, Dimmeler S & Kohl P. Novel therapeutic strategies targeting fibroblasts and fibrosis in heart disease. Nature Reviews Drug Discovery 2016: doi:10.1038/nrd.2016.89
Peyronnet R, Nerbonne JM & Kohl P. Cardiac mechano-gated ion channels and arrhythmias. Circ Res 2016/118 (2), 311-329
EA Rog-Zielinska, RA Norris, P Kohl & R Markwald. The living scar - cardiac fibroblasts and the injured heart. Trends Mol Med 2016/22:99-114.
Kohl P & Gourdie RG. Fibroblast-myocyte electrotonic coupling: Does it occur in native cardiac tissue? J Mol Cell Cardiol 2014/70:37-46.
Botcherby et al. Fast measurement of sarcomere length and cell orientation in Langendorff-perfused hearts using remote focusing microscopy. Circ Res 2013/113:863-70.
Yan et al. Palette of fluorinated voltage-sensitive hemicyanine dyes. Proc Natl Acad Sci USA 2012/109:20443-8.
Lee et al. Simultaneous voltage and calcium mapping of genetically purified human induced pluripotent stem cell-derived cardiac myocyte monolayers. Circ Res 2012/110:1556-63.
Bub et al. Temporal pixel multiplexing for simultaneous high-speed, high-resolution imaging. Nat Methods 2010/7:209-11.
Rodriguez et al. The systems biology approach to drug development: application to toxicity assessment of cardiac drugs. Clin Pharmacol Ther 2010/88:130-4.
Iribe et al. Axial stretch of rat single ventricular cardiomyocytes causes an acute and transient increase in Ca2+ spark rate. Circ Res 2009/104:787-95.
Pellis et al. Utility of pre-cordial thump for treatment of out of hospital cardiac arrest: a prospective study. Resuscitation 2009/80:17-23.
Camelliti et al. Micropatterned cell cultures on elastic membranes as an in vitro model of myocardium. Nat Protoc 2006/1:1379-91.
Camelliti et al. Fibroblast network in rabbit sinoatrial node: structural and functional identification of homogeneous and heterogeneous cell coupling. Circ Res 2004/94:828-35
Nesbitt et al. Rediscovering commotio cordis. The Lancet 2001/357:1195-7.
Kohl & Noble. Mechanosensitive connective tissue: potential influence on heart rhythm. Cardiovasc Res 1996/32:62-8.
et al., 2016, The Living Scar - Cardiac Fibroblasts and the Injured Heart, Trends In Molecular Medicine, Vol:22, ISSN:1471-4914, Pages:99-114
et al., 2016, Mechano-electric heterogeneity of the myocardium as a paradigm of its function, Progress In Biophysics & Molecular Biology, Vol:120, ISSN:0079-6107, Pages:249-254
Peyronnet R, Nerbonne JM, Kohl P, 2016, Cardiac Mechano-Gated Ion Channels and Arrhythmias, Circulation Research, Vol:118, ISSN:0009-7330, Pages:311-329
Ongstad E, Kohl P, 2016, Fibroblast-myocyte coupling in the heart: Potential relevance for therapeutic interventions, Journal of Molecular and Cellular Cardiology, Vol:91, ISSN:0022-2828, Pages:238-246
et al., 2016, A Bioreactor to Apply Multimodal Physical Stimuli to Cultured Cells., Methods Mol Biol, Vol:1502, Pages:21-33