Imperial College London
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ProfessorPeterKohl

Faculty of Medicine, National Heart & Lung Institute

Visiting Professor
 
 
 
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Contact

 

p.kohl Website

 
 
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Location

 

Heart Science CentreHarefield Hospital

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Summary

 

Publications

Citation

BibTex format

@article{Decher:2017:10.15252/emmm.201606690,
author = {Decher, N and Ortiz-Bonnin, B and Friedrich, C and Schewe, M and Kiper, AK and Rinné, S and Seemann, G and Peyronnet, R and Zumhagen, S and Bustos, D and Kockskämper, J and Kohl, P and Just, S and González, W and Baukrowitz, T and Stallmeyer, B and Schulze-Bahr, E},
doi = {10.15252/emmm.201606690},
journal = {EMBO Molecular Medicine},
pages = {403--414},
title = {Sodium permeable and "hypersensitive" TREK-1 channels cause ventricular tachycardia.},
url = {http://dx.doi.org/10.15252/emmm.201606690},
volume = {9},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - In a patient with right ventricular outflow tract (RVOT) tachycardia, we identified a heterozygous point mutation in the selectivity filter of the stretch-activated K2P potassium channel TREK-1 (KCNK2 or K2P2.1). This mutation introduces abnormal sodium permeability to TREK-1. In addition, mutant channels exhibit a hypersensitivity to stretch-activation, suggesting that the selectivity filter is directly involved in stretch-induced activation and desensitization. Increased sodium permeability and stretch-sensitivity of mutant TREK-1 channels may trigger arrhythmias in areas of the heart with high physical strain such as the RVOT We present a pharmacological strategy to rescue the selectivity defect of the TREK-1 pore. Our findings provide important insights for future studies of K2P channel stretch-activation and the role of TREK-1 in mechano-electrical feedback in the heart.
AU  - Decher,N
AU  - Ortiz-Bonnin,B
AU  - Friedrich,C
AU  - Schewe,M
AU  - Kiper,AK
AU  - Rinné,S
AU  - Seemann,G
AU  - Peyronnet,R
AU  - Zumhagen,S
AU  - Bustos,D
AU  - Kockskämper,J
AU  - Kohl,P
AU  - Just,S
AU  - González,W
AU  - Baukrowitz,T
AU  - Stallmeyer,B
AU  - Schulze-Bahr,E
DO  - 10.15252/emmm.201606690
EP  - 414
PY  - 2017///
SN  - 1757-4676
SP  - 403
TI  - Sodium permeable and "hypersensitive" TREK-1 channels cause ventricular tachycardia.
T2  - EMBO Molecular Medicine
UR  - http://dx.doi.org/10.15252/emmm.201606690
UR  - http://www.ncbi.nlm.nih.gov/pubmed/28242754
UR  - http://hdl.handle.net/10044/1/47994
VL  - 9
ER  -
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