Imperial College London
Alternate

ProfessorPaulLangford

Faculty of Medicine, Department of Infectious Disease

Professor of Paediatric Infectious Diseases
 
 
 
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Contact

 

+44 (0)20 7594 3359p.langford Website

 
 
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Location

 

236Wright Fleming WingSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Liu:2021:10.1186/s13567-020-00887-6,
author = {Liu, H and Lei, S and Jia, L and Xia, X and Sun, Y and Jiang, H and Zhu, R and Li, S and Qu, G and Gu, J and Sun, C and Feng, X and Han, W and Langford, PR and Lei, L},
doi = {10.1186/s13567-020-00887-6},
journal = {Veterinary Research},
pages = {30--30},
title = {Streptococcus suis serotype 2 enolase interaction with host brain microvascular endothelial cells and RPSA-induced apoptosis lead to loss of BBB integrity},
url = {http://dx.doi.org/10.1186/s13567-020-00887-6},
volume = {52},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Host proteins interacting with pathogens are receiving more attention as potential therapeutic targets in molecular medicine. Streptococcus suis serotype 2 (SS2) is an important cause of meningitis in both humans and pigs worldwide. SS2 Enolase (Eno) has previously been identified as a virulence factor with a role in altering blood brain barrier (BBB) integrity, but the host cell membrane receptor of Eno and The mechanism(s) involved are unclear. This study identified that SS2 Eno binds to 40S ribosomal protein SA (RPSA) on the surface of porcine brain microvascular endothelial cells leading to activation of intracellular p38/ERK-eIF4E signalling, which promotes intracellular expression of HSPD1 (heat-shock protein family D member 1), and initiation of host-cell apoptosis, and increased BBB permeability facilitating bacterial invasion. This study reveals novel functions for the host-interactional molecules RPSA and HSPD1 in BBB integrity, and provides insight for new therapeutic strategies in meningitis.
AU  - Liu,H
AU  - Lei,S
AU  - Jia,L
AU  - Xia,X
AU  - Sun,Y
AU  - Jiang,H
AU  - Zhu,R
AU  - Li,S
AU  - Qu,G
AU  - Gu,J
AU  - Sun,C
AU  - Feng,X
AU  - Han,W
AU  - Langford,PR
AU  - Lei,L
DO  - 10.1186/s13567-020-00887-6
EP  - 30
PY  - 2021///
SN  - 1994-4659
SP  - 30
TI  - Streptococcus suis serotype 2 enolase interaction with host brain microvascular endothelial cells and RPSA-induced apoptosis lead to loss of BBB integrity
T2  - Veterinary Research
UR  - http://dx.doi.org/10.1186/s13567-020-00887-6
UR  - https://www.ncbi.nlm.nih.gov/pubmed/33618766
UR  - http://hdl.handle.net/10044/1/86413
VL  - 52
ER  -
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