Imperial College London

Professor Paul D. Lickiss

Faculty of Natural SciencesDepartment of Chemistry

Professor of Organometallic Chemistry
 
 
 
//

Contact

 

+44 (0)20 7594 5761p.lickiss Website

 
 
//

Location

 

601DMolecular Sciences Research HubWhite City Campus

//

Summary

 

Publications

Publication Type
Year
to

161 results found

Delmas LC, White AJP, Pugh D, Evans A, Isbell MA, Heng JYY, Lickiss PD, Davies RPet al., 2020, Stable metal-organic frameworks with low water affinity built from methyl-siloxane linkers, CHEMICAL COMMUNICATIONS, Vol: 56, Pages: 7905-7908, ISSN: 1359-7345

Journal article

Al-Ansari DE, Mohamed NA, Marei I, Zekri A, Kameno Y, Davies RP, Lickiss PD, Rahman MM, Abou-Saleh Het al., 2020, Internalization of Metal-Organic Framework Nanoparticles in Human Vascular Cells: Implications for Cardiovascular Disease Therapy, NANOMATERIALS, Vol: 10

Journal article

Mohamed NA, Davies RP, Lickiss PD, Kameno Y, Marei I, Kirkby NS, Mitchell JA, Abou Saleh Het al., 2019, Mil-89 nanoformulation as a platform to improve pulmonary arterial hypertension treatment, British-Pharmacology-Society Meeting (Pharmacology), Publisher: WILEY, Pages: 3075-3075, ISSN: 0007-1188

Conference paper

Pugh D, Ashworth E, Robertson K, Delmas L, White A, Horton P, Tizzard G, Coles S, Lickiss P, Davies Ret al., 2019, Metal-organic frameworks constructed from group 1 metals (Li, Na) and silicon-centered linkers, Crystal Growth and Design, Vol: 19, Pages: 487-497, ISSN: 1528-7483

A series of “light metal” metal–organic frameworks containing secondary building units (SBUs) based on Li+ and Na+ cations have been prepared using the silicon-centered linkers MexSi(p-C6H4CO2H)4-x (x = 2, 1, 0). The unipositive charge, small size, and oxophilic nature of the metal cations give rise to some unusual and unique SBUs, including a three-dimensional nodal structure built from sodium and oxygen ions when using the triacid linker (x = 1). The same linker with Li+ cations generated a chiral, helical SBU, formed from achiral starting materials. One-dimensional rod SBUs are observed for the diacid (x = 2) and tetra-acid (x = 0) linkers with both Li+ and Na+ cations, where the larger size of Na+ compared to Li+ leads to subtle differences in the constitution of the metal nodes.

Journal article

Davies RP, Delmas L, Horton P, White A, Coles S, Lickiss Pet al., 2019, Studies on the structural diversity of MOFs containing octahedral siloxane-backboned connectors, Polyhedron, Vol: 157, Pages: 25-32, ISSN: 0277-5387

Four metal–organic frameworks containing hexatopic connectors have been prepared and structurally characterised: [Cd3(L)(DMA)2(H2O)2] (IMP-28), [Ce2(L)(DMF)2(H2O)2] (IMP-29), [Y2(L)(DMF)2(H2O)2] (IMP-30), and [Zn2(L-H2)(4,4′-bipy)2] (IMP-31). All the MOFs have been constructed using the hybrid inorganic–organic siloxane linker hexakis(4-carboxyphenyl)disiloxane (L-H6). In each case, discrete metal-based nodes are cross-linked by the octahedrally disposed connector to afford 3D polymeric structures. The underlying nets in these MOFs have been evaluated through deconstruction of their crystal structures and subsequent topological analysis. Examples of MOFs built from hexatopic linkers, and especially those with octahedral predispositions such as in L, remain scarce and the topologies ascribed to some of these MOFs are unique.

Journal article

Delmas L, White A, Pugh D, Horton P, Coles S, Lickiss P, Davies RPet al., 2018, Trisiloxane-centred metal-organic frameworks and hydrogen bonded assemblies, CrystEngComm, Vol: 20, Pages: 4541-4545, ISSN: 1466-8033

A hexacarboxylic acid with a trisiloxane backbone (L-H6) has been prepared and applied in MOF construction. L-H6 itself crystallizes as an unusual 2D hydrogen-bonded network. Reaction of L-H6 with Mn(II) gave IMP-20 and with Zn(II) gave IMP-21: both are 3D MOFs incorporating Si–O–Si–O–Si linkages.

Journal article

Braddock DC, Lickiss P, Rowley B, Pugh DC, purnomo, Santhakumar G, fussell Set al., 2018, Tetramethyl Orthosilicate (TMOS) as a Reagent for Direct Amidation of Carboxylic Acids, Organic Letters, Vol: 20, Pages: 950-953, ISSN: 1523-7052

Tetramethyl orthosilicate (TMOS) is shown to be an effective reagent for direct amidation of aliphatic and aromatic carboxylic acids with amines and anilines. The amide products are obtained in good to quantitative yields in pure form directly after workup without the need for any further purification. A silyl ester as the putative activated intermediate is observed by NMR methods. Amidations on a 1 mol scale are demonstrated with a favorable process mass intensity.

Journal article

Davies RP, Delmas L, Horton PN, White AJP, Coles SJ, Lickiss PDet al., 2017, Siloxane-based linkers in the construction of hydrogen bonded assemblies and porous 3D MOFs, Chemical Communications, Vol: 53, Pages: 12524-12527, ISSN: 1359-7345

A siloxane-based hexacarboxylic acid (L1-H6) has been prepared and applied in MOF construction. L1-H6 itself crystallizes as an unusual interpenetrated 3D hydrogen-bonded framework. Reaction of L1-H6 with Zn(II) gave IMP-18 – a 3D MOF incorporating Si–O–Si functionality. Cleavage of L1-H6 gives a silanol-based triacid which is shown to give a coordination polymer (IMP-19) with Zn(II).

Journal article

Mohamed NA, Davies RP, Lickiss PD, Ahmetaj-Shala B, Reed DM, Gashaw HH, Saleem H, Freeman GR, George PM, Wort SJ, Morales-Cano D, Barreira B, Tetley TD, Chester AH, Yacoub MH, Kirkby NS, Moreno L, Mitchell JAet al., 2017, Chemical and biological assessment of metal organic frameworks (MOFs) in pulmonary cells and in an acute in vivo model: relevance to pulmonary arterial hypertension therapy, Pulmonary Circulation, Vol: 7, Pages: 1-11, ISSN: 2045-8940

Pulmonary arterial hypertension (PAH) is a progressive and debilitating condition. Despite promoting vasodilation, current drugs have a therapeutic window within which they are limited by systemic side effects. Nanomedicine uses nanoparticles to improve drug delivery and/or reduce side effects. We hypothesize that this approach could be used to deliver PAH drugs avoiding the systemic circulation. Here we report the use of iron metal organic framework (MOF) MIL-89 and PEGylated MIL-89 (MIL-89 PEG) as suitable carriers for PAH drugs. We assessed their effects on viability and inflammatory responses in a wide range of lung cells including endothelial cells grown from blood of donors with/without PAH. Both MOFs conformed to the predicted structures with MIL-89 PEG being more stable at room temperature. At concentrations up to 10 or 30 µg/mL, toxicity was only seen in pulmonary artery smooth muscle cells where both MOFs reduced cell viability and CXCL8 release. In endothelial cells from both control donors and PAH patients, both preparations inhibited the release of CXCL8 and endothelin-1 and in macrophages inhibited inducible nitric oxide synthase activity. Finally, MIL-89 was well-tolerated and accumulated in the rat lungs when given in vivo. Thus, the prototypes MIL-89 and MIL-89 PEG with core capacity suitable to accommodate PAH drugs are relatively non-toxic and may have the added advantage of being anti-inflammatory and reducing the release of endothelin-1. These data are consistent with the idea that these materials may not only be useful as drug carriers in PAH but also offer some therapeutic benefit in their own right.

Journal article

Tome LC, Gouveia ASL, Ab Ranii MA, Lickiss PD, Welton T, Marrucho IMet al., 2017, Study on Gas Permeation and CO2 Separation through Ionic Liquid Based Membranes with Siloxane-Functionalized Cations, Industrial & Engineering Chemistry Research, Vol: 56, Pages: 2229-2239, ISSN: 0888-5885

This work explores ionic liquid-based membranes with siloxane functionalized cations using two different approaches: supported ionic liquid membranes (SILMs) and poly(ionic liquid)–ionic liquid (PIL–IL) composite membranes. Their CO2, CH4, and N2 permeation properties were measured at T = 293 K with a trans-membrane pressure differential of 100 kPa. The thermophysical properties of the synthesized siloxane-functionalized ILs, namely viscosity and density (data in the Supporting Information), were also determined. Contrary to what was expected, the gas permeation results show that the SILMs containing siloxane-functionalized cations have CO2 permeabilities that are lower than those of their analogues without the siloxane functionality. The addition of siloxane-based ILs into PILs increases both CO2 permeability and CO2/N2 permselectivity, although it does not significantly change the CO2/CH4 permselectivity. The prepared membranes present very diverse CO2 permeabilities, between 57 and 568 Barrer, while they show permselectivities varying from 16.8 to 36.8 for CO2/N2 and from 9.8 to 11.5 for CO2/CH4. As observed for other ILs, superior CO2 separation performances were obtained when the IL containing [C(CN)3]− is used compared to that having the [NTf2]− anion.

Journal article

Mohamed NA, Ahmetaj-Shala B, Duluc L, Mackenzie LS, Kirkby NS, Reed DM, Lickiss PD, Davies RP, Freeman GR, Wojciak-Stothard B, Chester AH, El-Sherbiny IM, Mitchell JA, Yacoub MHet al., 2016, A New NO-Releasing Nanoformulation for the Treatment of Pulmonary Arterial Hypertension., Journal of Cardiovascular Translational Research, Vol: 9, Pages: 162-164, ISSN: 1937-5395

Pulmonary arterial hypertension (PAH) is a chronic and progressive disease which continues to carry an unacceptably high mortality and morbidity. The nitric oxide (NO) pathway has been implicated in the pathophysiology and progression of the disease. Its extremely short half-life and systemic effects have hampered the clinical use of NO in PAH. In an attempt to circumvent these major limitations, we have developed a new NO-nanomedicine formulation. The formulation was based on hydrogel-like polymeric composite NO-releasing nanoparticles (NO-RP). The kinetics of NO release from the NO-RP showed a peak at about 120 min followed by a sustained release for over 8 h. The NO-RP did not affect the viability or inflammation responses of endothelial cells. The NO-RP produced concentration-dependent relaxations of pulmonary arteries in mice with PAH induced by hypoxia. In conclusion, NO-RP drugs could considerably enhance the therapeutic potential of NO therapy for PAH.

Journal article

Mohamed NA, Davies R, Lickiss PD, Freeman G, Morales-Cano D, Barreira B, Kirkby NS, Moreno L, Mitchell JAet al., 2016, In vivo assessment of metal organic framework (MOFs) for the future use as delivery agents for drugs to treat PAH

Conference paper

Wann DA, Robinson MS, Baetz K, Masters SL, Avent AG, Lickiss PDet al., 2015, Structures of Tetrasilylmethane Derivatives (XMe2Si)(2)C(SiMe3)(2) (X = H, Cl, Br) in the Gas Phase, and their Dynamic Structures in Solution, JOURNAL OF PHYSICAL CHEMISTRY A, Vol: 119, Pages: 786-795, ISSN: 1089-5639

Journal article

Wann DA, Young S, Baetz K, Masters SL, Avent AG, Rankin DWH, Lickiss PDet al., 2014, Structures of Tetrasilylmethane Derivatives C(SiXMe2)(4) (X = H, F, Cl, Br) in the Gas Phase and their Dynamic Structures in Solution, ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES, Vol: 69, Pages: 1321-1332, ISSN: 0932-0776

Journal article

Timokhin I, White AJP, Lickiss PD, Pettinari C, Davies RPet al., 2014, Microporous metal-organic frameworks built from rigid tetrahedral tetrakis(4-tetrazolylphenyl)silane connectors, CRYSTENGCOMM, Vol: 16, Pages: 8094-8097, ISSN: 1466-8033

Journal article

Ab Rani MA, Borduas N, Colquhoun V, Hanley R, Johnson H, Larger S, Lickiss PD, Llopis-Mestre V, Luu S, Mogstad M, Oczipka P, Sherwood JR, Welton T, Xing J-Yet al., 2013, The potential of methylsiloxanes as solvents for synthetic chemistry applications, Green Chemistry, Vol: 16, Pages: 1282-1296, ISSN: 1744-1560

The potential use of volatile methylsiloxanes (VMSs) as solvents for chemicals synthesis has been explored. Assessment of the environmental impact of these VMS solvents is made and found to be significantly lower than those of the non-polar organic solvents that they have the potential to replace. The polarities of the VMSs, as expressed by empirical polarity measurements, and miscibilities with other liquids are found to be similar to those of alkane solvents. Finally, some uses of VMSs as solvents for both organic and inorganic transformations are described. The VMSs provide environmentally more sustainable (greener) alternatives to the nonpolar solvents that they have the potential to replace.

Journal article

Timokhin I, Torres JB, White AJP, Lickiss PD, Pettinari C, Davies RPet al., 2013, Organosilicon linkers in metal organic frameworks: the tetrahedral tetrakis(4-tetrazolylphenyl)silane ligand, DALTON TRANSACTIONS, Vol: 42, Pages: 13806-13808, ISSN: 1477-9226

Journal article

Bulut S, Ab Rani MA, Welton T, Lickiss PD, Krossing Iet al., 2012, Preparation of [Al(hfip)4]--Based Ionic Liquids with Siloxane-Functionalized Cations and Their Physical Properties in Comparison with Their [Tf2N]- Analogues, CHEMPHYSCHEM, Vol: 13, Pages: 1802-1805, ISSN: 1439-4235

Journal article

Davies RP, Lickiss PD, Robertson K, White AJPet al., 2012, An organosilicon hexacarboxylic acid and its use in the construction of a novel metal organic framework isoreticular to MOF-5, CRYSTENGCOMM, Vol: 14, Pages: 758-760, ISSN: 1466-8033

Journal article

Davies RP, Lickiss PD, Robertson K, White AJPet al., 2012, An Organosilicon hexacarboxylic acid and its use in the construction of a novel metal organic framework isoreticular to MOF-5, CrystEngComm, Vol: 14, Pages: 758-760

A novel hexacarboxylate organo-silicon molecule has been synthesised and used in the construction of a new MOF of pcu topology and isoreticular to MOF-5.

Journal article

Wann DA, Dickson CN, Lickiss PD, Robertson HE, Rankin DWHet al., 2011, The Gas-Phase Equilibrium Structures of Si8O12(OSiMe3)(8) and Si8O12(CHCH2)(8), INORGANIC CHEMISTRY, Vol: 50, Pages: 2988-2994, ISSN: 0020-1669

Journal article

Davies RP, Lickiss PD, Robertson K, 2011, Coordination polymers containing novel silicon-based connectors, 241st National Meeting and Exposition of the American-Chemical-Society (ACS), Publisher: AMER CHEMICAL SOC, ISSN: 0065-7727

Conference paper

Davies RP, Lickiss PD, Robertson K, White AJPet al., 2011, Mg-II, Ca-II, and Co-II Metal-Organic Framework Materials with [Si(p-C6H4CO2)(3)(p-C6H4CO2H)](3-) Struts, AUSTRALIAN JOURNAL OF CHEMISTRY, Vol: 64, Pages: 1237-1244, ISSN: 0004-9425

Journal article

Davies RP, Less R, Lickiss PD, Robertson K, White AJPet al., 2010, Structural Diversity in Metal-Organic Frameworks Built from Rigid Tetrahedral [Si(p-C6H4CO2)(4)](4-) Struts, CRYSTAL GROWTH & DESIGN, Vol: 10, Pages: 4571-4581, ISSN: 1528-7483

Journal article

Cordes DB, Lickiss PD, Rataboul F, 2010, Recent Developments in the Chemistry of Cubic Polyhedral Oligosilsesquioxanes, CHEMICAL REVIEWS, Vol: 110, Pages: 2081-2173, ISSN: 0009-2665

Journal article

Boag NM, Jackson AD, Lickiss PD, Pilkington RD, Redhouse ADet al., 2010, trans-Bis(1,1,1,5,5,5-hexafluoropentane-2,4-dionato-kappa O-2,O ')bis(4-methyl-1,2,3-selenadiazole-kappa N-3)copper(II), ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, Vol: 66, Pages: M241-U1437, ISSN: 1600-5368

Journal article

Masters SL, Rankin DWH, Cordes DB, Baetz K, Lickiss PD, Boag NM, Redhouse AD, Whittaker SMet al., 2010, The gas-phase structure and some reactions of the bulky primary silane (Me3Si)(3)CSiH3 and the solid-state structure of the bulky dialkyl disilane [(Me3Si)(3)CSiH2](2), DALTON TRANSACTIONS, Vol: 39, Pages: 9353-9360, ISSN: 1477-9226

Journal article

Zakharov AV, Masters SL, Wann DA, Shlykov SA, Girichev GV, Arrowsmith S, Cordes DB, Lickiss PD, White AJPet al., 2010, The gas-phase structure of octaphenyloctasilsesquioxane Si8O12Ph8 and the crystal structures of Si8O12(p-tolyl)(8) and Si8O12(p-ClCH2C6H4)(8), DALTON TRANSACTIONS, Vol: 39, Pages: 6960-6966, ISSN: 1477-9226

Journal article

Niedermeyer H, Ab Rani MA, Lickiss PD, Hallett JP, Welton T, White AJP, Hunt PAet al., 2010, Understanding siloxane functionalised ionic liquids, Phys. Chem. Chem. Phys., Vol: 12, Pages: 2018-2029-2018-2029

Journal article

Wann DA, Reilly AM, Rataboul F, Lickiss PD, Rankin DWHet al., 2009, The Gas-phase Structure of the Hexasilsesquioxane Si6O9(OSiMe3)(6), ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES, Vol: 64, Pages: 1269-1275, ISSN: 0932-0776

Journal article

This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.

Request URL: http://wlsprd.imperial.ac.uk:80/respub/WEB-INF/jsp/search-html.jsp Request URI: /respub/WEB-INF/jsp/search-html.jsp Query String: respub-action=search.html&id=00151832&limit=30&person=true