Imperial College London
Alternate

prof paul f. luckham

Faculty of Engineering, Department of Chemical Engineering

Professor in Particle Technology
 
 
 
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Contact

 

+44 (0)20 7594 5583p.luckham01 Website

 
 
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Assistant

 

Miss Jessica Baldock +44 (0)20 7594 5699

 
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Location

 

104Roderic Hill BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Luckham:2016:10.1016/j.jcis.2016.02.052,
author = {Luckham, PF and Elizarova, I},
doi = {10.1016/j.jcis.2016.02.052},
journal = {Journal of Colloid and Interface Science},
pages = {92--99},
title = {Fabrication of polyelectrolyte multilayered nano-capsules using a continuous layer-by-layer approach},
url = {http://dx.doi.org/10.1016/j.jcis.2016.02.052},
volume = {470},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The layer-by-layer approach is a highly versatile method for the fabrication of multilayered polymeric films and capsules. It has been widely investigated in research for various polyelectrolyte pairs and core template particles. However, the fabrication of nano-sized capsules at the larger scale is difficult and time consuming, due to the necessity of washing and centrifugation steps before the deposition of each polyelectrolyte layer. This results not only in a very long fabrication time, but also in the partial loss of particles during those intermediate steps. In this study, we introduced a continuous approach for the fabrication of multilayer polyelectrolyte based nano-capsules using calcium phosphate core nanoparticles and a tubular flow type reactor with the potential for synthesizing tens of milligrams of capsules per hour. Adsorption of the polyelectrolyte layer occurred in the tubing where particles and polyelectrolyte solution of choice were mixed, creating a layer of polyelectrolyte on the particles. After this, these newly surfaced-modified particles passed into the next segment of tubing, where they were mixed with a second polyelectrolyte of opposite charge. This process can be continuously repeated until the desired number of layers is achieved. One potential problem with this method concerned the presence of any excess polyelectrolyte in the tubing, so careful control of the amount of polymer added was crucial. It was found that slightly under dosing the amount of added polyelectrolyte ensured that negligible unadsorbed polyelectrolyte remained in solution. The particles created at each deposition step were stable, as they all had a zeta potential of greater than ±25 mV. Furthermore the zeta potential measurements showed that charge reversal occurred at each stage. Having achieved the necessary number of polyelectrolyte layers, the calcium phosphate cores were easily removed via dissolution in either hydrochloric or acetic acid.
AU  - Luckham,PF
AU  - Elizarova,I
DO  - 10.1016/j.jcis.2016.02.052
EP  - 99
PY  - 2016///
SN  - 0021-9797
SP  - 92
TI  - Fabrication of polyelectrolyte multilayered nano-capsules using a continuous layer-by-layer approach
T2  - Journal of Colloid and Interface Science
UR  - http://dx.doi.org/10.1016/j.jcis.2016.02.052
UR  - https://www.sciencedirect.com/science/article/pii/S0021979716301321
UR  - http://hdl.handle.net/10044/1/29902
VL  - 470
ER  -
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