Imperial College London
Alternate

Dr Paul F. McKay

Faculty of Medicine, Department of Infectious Disease

Advanced Research Fellow
 
 
 
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Contact

 

+44 (0)20 7594 2542p.mckay

 
 
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Location

 

125 (Shattock Group)Wright Fleming WingSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Petrova:2018:10.3389/fimmu.2018.01784,
author = {Petrova, V and Muir, L and McKay, P and Vassiliou, G and Smith, K and Lyons, P and Russell, C and Anderson, C and Kellam, P and Bashford-Rogers, R},
doi = {10.3389/fimmu.2018.01784},
journal = {Frontiers in Immunology},
title = {Combined influence of B-cell receptor rearrangement and somatic hypermutation on B-cell class-switch fate in health and in chronic lymphocytic leukaemia},
url = {http://dx.doi.org/10.3389/fimmu.2018.01784},
volume = {9},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - A diverse B-cell receptor (BCR) repertoire is required to bind a wide range of antigens.BCRs are generated through genetic recombination and can be diversified throughsomatic hypermutation (SHM) or class-switch recombination (CSR). Patterns of repertoirediversity can vary substantially between different health conditions. We use isotyperesolvedBCR sequencing to compare B-cell evolution and class-switch fate in healthyindividuals and in patients with chronic lymphocytic leukemia (CLL). We show that thepatterns of SHM and CSR in B-cells from healthy individuals are distinct from CLL. Weidentify distinct properties of clonal expansion that lead to the generation of antibodiesof different classes in healthy, malignant, and non-malignant CLL BCR repertoires. Wefurther demonstrate that BCR diversity is affected by relationships between antibodyvariable and constant regions leading to isotype-specific signatures of variable geneusage. This study provides powerful insights into the mechanisms underlying the evolutionof the adaptive immune responses in health and their aberration during disease.
AU  - Petrova,V
AU  - Muir,L
AU  - McKay,P
AU  - Vassiliou,G
AU  - Smith,K
AU  - Lyons,P
AU  - Russell,C
AU  - Anderson,C
AU  - Kellam,P
AU  - Bashford-Rogers,R
DO  - 10.3389/fimmu.2018.01784
PY  - 2018///
SN  - 1664-3224
TI  - Combined influence of B-cell receptor rearrangement and somatic hypermutation on B-cell class-switch fate in health and in chronic lymphocytic leukaemia
T2  - Frontiers in Immunology
UR  - http://dx.doi.org/10.3389/fimmu.2018.01784
UR  - http://hdl.handle.net/10044/1/62873
VL  - 9
ER  -
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