Imperial College London
Alternate

Dr Paul F. McKay

Faculty of Medicine, Department of Infectious Disease

Advanced Research Fellow
 
 
 
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Contact

 

+44 (0)20 7594 2542p.mckay

 
 
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Location

 

125 (Shattock Group)Wright Fleming WingSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Mann:2016:10.1016/j.jconrel.2016.04.022,
author = {Mann, JF and Tregoning, JS and Aldon, Y and Shattock, RJ and McKay, PF},
doi = {10.1016/j.jconrel.2016.04.022},
journal = {Journal of Controlled Release},
pages = {75--82},
title = {CD71 targeting boosts immunogenicity of sublingually delivered influenza haemagglutinin antigen and protects against viral challenge in mice.},
url = {http://dx.doi.org/10.1016/j.jconrel.2016.04.022},
volume = {232},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The delivery of vaccines to the sublingual mucosa is an attractive prospect due to the ease and acceptability of such an approach. However, novel adjuvant and delivery approaches are required to optimally vaccinate at this site. We have previously shown that conjugation of protein antigen to the iron transport molecule, transferrin, can significantly enhance mucosal immune responses. We tested whether conjugating influenza haemagglutinin to transferrin could improve the immune response to sublingually delivered antigen. Transferrin conjugated haemagglutinin induced a significant antibody and T cell response in both naïve animals and previously immunized animals. The immune response generated was able to protect mice against influenza virus challenge. Sublingually administered antigen dispersed more widely through the gastro-intestinal tract than intranasally delivered antigen and transferrin conjugation had a more marked effect on sublingually delivered antigen than intranasal immunisation. From these studies we conclude that transferrin conjugation of antigen is effective at boosting immune responses to sublingually delivered antigen and may be an attractive approach for influenza vaccines, particularly when mass campaigns are required.
AU  - Mann,JF
AU  - Tregoning,JS
AU  - Aldon,Y
AU  - Shattock,RJ
AU  - McKay,PF
DO  - 10.1016/j.jconrel.2016.04.022
EP  - 82
PY  - 2016///
SN  - 1873-4995
SP  - 75
TI  - CD71 targeting boosts immunogenicity of sublingually delivered influenza haemagglutinin antigen and protects against viral challenge in mice.
T2  - Journal of Controlled Release
UR  - http://dx.doi.org/10.1016/j.jconrel.2016.04.022
UR  - http://hdl.handle.net/10044/1/31340
VL  - 232
ER  -
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