Imperial College London
Alternate

Dr Paul F. McKay

Faculty of Medicine, Department of Infectious Disease

Advanced Research Fellow
 
 
 
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Contact

 

+44 (0)20 7594 2542p.mckay

 
 
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Location

 

125 (Shattock Group)Wright Fleming WingSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Pankrac:2018:10.1038/s41541-017-0040-6,
author = {Pankrac, J and Klein, K and McKay, PF and King, DFL and Bain, K and Knapp, J and Biru, T and Wijewardhana, CN and Pawa, R and Canaday, DH and Gao, Y and Fidler, S and Shattock, RJ and Arts, EJ and Mann, JFS},
doi = {10.1038/s41541-017-0040-6},
journal = {npj Vaccines},
title = {A heterogeneous human immunodeficiency virus-like particle (VLP) formulation produced by a novel vector system.},
url = {http://dx.doi.org/10.1038/s41541-017-0040-6},
volume = {3},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - First identified as the etiological agent behind Acquired Immunodeficiency Syndrome (AIDS) in the early 1980s, HIV-1 has continued to spread into a global pandemic and major public health concern. Despite the success of antiretroviral therapy at reducing HIV-1 viremia and preventing the dramatic CD4+ T-cell collapse, infected individuals remain HIV positive for life. Unfortunately, it is increasingly clear that natural immunity is not, and may never be, protective against this pathogen. Therefore, efficacious vaccine interventions, which can either prevent infection or eradicate the latent viral reservoir and effect cure, are a major medical priority. Here we describe the development of a safe vaccine platform, currently being utilized in on-going prophylactic and therapeutic preclinical studies and consisting of highly heterogeneous virus-like particle formulations that represent the virus diversity within infected individuals. These VLPs contain no 5'LTR, no functional integrase, and have a severely mutated stem loop 1-thereby preventing any potential reverse transcription, integration, and RNA packaging. Furthermore, we demonstrate that these VLPs are morphologically identical to wild-type virus with polyvalent Env in a functional form. Finally, we show that the VLPs are antigenic and capable of generating strong immune recall responses.
AU  - Pankrac,J
AU  - Klein,K
AU  - McKay,PF
AU  - King,DFL
AU  - Bain,K
AU  - Knapp,J
AU  - Biru,T
AU  - Wijewardhana,CN
AU  - Pawa,R
AU  - Canaday,DH
AU  - Gao,Y
AU  - Fidler,S
AU  - Shattock,RJ
AU  - Arts,EJ
AU  - Mann,JFS
DO  - 10.1038/s41541-017-0040-6
PY  - 2018///
SN  - 2059-0105
TI  - A heterogeneous human immunodeficiency virus-like particle (VLP) formulation produced by a novel vector system.
T2  - npj Vaccines
UR  - http://dx.doi.org/10.1038/s41541-017-0040-6
UR  - http://hdl.handle.net/10044/1/56550
VL  - 3
ER  -
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